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Showing 1 to 10 of 10 for “"Mitochondrial fission and fusion"”.
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THE PROSURVIVAL ACTIVITIES OF APOPTOSIS-INDUCING FACTOR CONVERGE UPON THE REGULATION OF MITOCHONDRIAL METABOLISM, A NOVEL CELL DEATH PATHWAY, AND THE PROGRESSION OF PROSTATE CANCER
Apoptosis-inducing factor (AIF) is a mitochondrial NADH-oxidase originally discovered for its ability to trigger apoptosis through chromatin condensation and DNA cleavage. Although AIF is recognized for its apoptotic function, AIF-mediated cell death has emerged as an atypical cell death pathway; …
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Burn Serum Stimulates Mitochondrial Fission in C2C12 Myoblasts
… with a hypercatabolic status. Impairment of mitochondrial function has been observed in the muscle of burn patient's. OBJECTIVE: We hypothesize that muscle atrophy due to burn injur y is associated with an alteration in mitochondrial dynamics. This study was designed to investigate changes in …
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Mechanism on Elongated Mitochondria Formation during Iorn Chelation-Induced Senescent Arrest
… have often been documented in aged tissues and several human disease harboring impaired function, although their role and the mechanism involved remain unclear. Recently, we observed progressive changes of mitochondrial morphology to highly elongated form during iron chelation-induced …
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Mitochondrial dynamics in the radiation response of cancer cells
… that determine the response of cells to damage. Mitochondrial fission and fusion are associated with cell cycle regulation, apoptosis, cellular bioenergetics and redox status, which contribute to cellular homeostasis and damage response. The study aimed to describe and correlate cancer cell …
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Insights Into Mitochondrial Genetic and Morphologic Dynamics Gained by Stochastic Simulation
… cells are implicated in cellular ageing and encephalomyopathies, although mechanisms involved are not completely understood. The mitochondrial genetic bottleneck has puzzled biologists for a long time. Approximate models of genetic bottleneck proposed in the literature do not accurately …
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Molecular and Cellular Mechanisms Responsible for Low-grade Stress and Inflammation Triggered By Super-low Dose Endotoxin
… researched in high doses (10-200ng/ml) and is well-documented in the literature for its ability to result in devastating effects such as multi-organ failure, sepsis, and septic shock. In high doses, LPS signals through Toll-like-receptor 4 (TLR4) and triggers a cascade of events …
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Mitochondrial structure and distribution in Saccharomyces cerevisiae
Mitochondria play diverse roles in the physiology and metabolism of eukaryotic cells. Like most membrane bounded organelles, they cannot be synthesized de novo but grow and split into distinct organelles and must be inherited to daughter cells upon cell division. The structure of the highly dynamic …
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Characterisation of new factors regulating mitochondrial dynamics and cellular metabolism
… plasticity which governs their shape, size and distribution. This dynamic behaviour depends on continuous cycles of fission or fusion, which is mediated by large GTPase enzymes, facilitating the remodelling of the network to adapt and answer to cellular needs. However, the underlying …
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IMPACT OF DRP1 ACTIVATION, UNFOLDED PROTEIN RESPONSE INDUCTION AND FGF21 LEVELS IN DMD PROGRESSION
… to motor impairments very early in childhood and if not adequately treated, they die prematurely because of cardiac or respiratory complications. Mutations in the DMD gene that lead to the complete loss of dystrophin protein are responsible for this very severe phenotype. Dystrophin is a …