Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Mitochondrial complex I"”.
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Disease biology of mitochondrial complex-I: Proteomics insights
Contains fulltext : 110935.pdf (Publisher’s version ) (Open Access)
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Cryo-electron microscopy studies on ovine mitochondrial complex I
… the atomic structure of mammalian respiratory complex I. Mitochondrial complex I (also known as NADH:ubiquinone oxidoreductase) is one of the central enzymes in the oxidative phosphorylation pathway. It couples electron transfer between NADH and ubiquinone to proton translocation across the …
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Investigating the rate-limiting step of mitochondrial complex I catalysis
Respiratory complex I (NADH:ubiquinone oxidoreductase) is a key enzyme in metabolism and is the least understood protein in the mitochondrial electron transfer chain (ETC). It couples the energy released from NADH oxidation and ubiquinone (Q) reduction to the translocation of four protons across …
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Investigations of the mechanism of mitochondrial complex I by electron cryomicroscopy
… chain (ETC). The first enzyme in the ETC is complex I (NADH:ubiquinone oxidoreductase). Complex I oxidises NADH in the matrix, reduces ubiquinone in the inner membrane, and couples the energy released to the translocation of four protons across the inner membrane, generating the proton motive …
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Novel approaches to treat mitochondrial complex-I mediated defects in disease
Dysfunction within complex I (CI) of the mitochondrial electron transport system has been implicated in a number of disease states ranging from cardiovascular diseases to neuro-ophthalmic indications. Herein, we provide three novel approaches to model and study the impacts of injury on the function …
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The assembly of mitochondrial Complex I. A product of nuclear-mitochondrial synergy.
Contains fulltext : 30935_asseofmic.pdf (Publisher’s version ) (Open Access)
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A Multi-Factorial Assessment of Partial Mitochondrial Complex I Impairment in Colorectal Cancer
… and progression remain poorly defined. Mitochondrial metabolism, particularly the function of respiratory complex I, has emerged as a key determinant of tumor bioenergetics and signaling. This dissertation investigates how partial complex I dysfunction influences CRC tumor growth and …
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Elucidating the Target and Selectivity of a Non-Small Cell Lung Cancer Toxin
… probes, we found that the QDC targets mitochondrial Complex I. We investigated the selective toxicity of Complex I inhibition across NSCLC and found that a high baseline content of aspartate formed via reductive glutamine metabolism promotes resistance to mitochondrial inhibition. …
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Developing C. elegans as a model to study Type 2 Diabetes Mellitus
… metabolic rate by partially inhibiting the mitochondrial complex I in mammals. Using C. elegans as a genetic model organism, we show that metformin reduces the mitochondrial activity through endosomal Na+/H+ exchanger, which a previous lab member has found to be a potential target of …
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Pharmacological aspects of the inhibition of mammalian respiratory complex I
Mitochondrial complex I, a large respiratory enzyme located in the inner mitochondrial membrane, catalyses electron transfer from NADH to ubiquinone while concomitantly translocating protons across the membrane to sustain ATP synthesis. A crucial aspect of the pharmacology of complex I is …
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The Role of ECSIT in Mitochondrial Dysfunction Mediated Cardiomyopathy
… embryonic development. It also functions as a mitochondrial complex I assembly factor and loss of function leads to a reduction in fully assembled complex I. As part of a large scale ENU mutagenesis screen, The Harwell Ageing Screen, a novel missense mutation (N209I) was identified in ECSIT …
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OXIDATIVE PHOSPHORYLATION IN MELANOMA BRAIN METASTASES: A REGULATOR of THE TUMOR IMMUNE LANDSCAPE
… and <em>Ndfus4 </em>(NDUFS4), a component of mitochondrial complex I. PGC1a KO in an RCAS-TVA mouse model of autochthonous lung and brain tumors developing from primary melanomas significantly reduced the incidence of lung and brain tumor formation. Further characterization of OXPHOS at later …
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Discovery of small-molecule natural products that target cellular bioenergetics
… enhance the effectiveness of current therapies. Mitochondrial oxidative phosphorylation inhibitors in botanical dietary supplements (BDS) possess a potential health hazard which should be identified and appropriately regulated. Chapter one briefly reviews the molecular-targeted natural product …
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Structural and functional studies of mitochondrial NADH:ubiquinone oxidoreductase (complex I)
NADH:ubiquinone oxidoreductase (complex I) is the largest and most complicated enzyme in the mitochondrial electron transfer chain. It catalyses the oxidation of NADH and the reduction of ubiquinone, coupled to the translocation of protons across the mitochondrial inner membrane, maintaining the …
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Reactive oxygen and nitrogen species production in cardiomyoblasts during hypoxia and reoxygenation
… O2 and 10% O2 was dependent on the production of mitochondrial superoxide (O2-•) and nitric oxide (•NO), partly from nitric oxide synthase (NOS). Both apoptotic and necrotic cell death during 2% O2 for 4h could be rescued by the mitochondrial complex I inhibitor; rotenone and NOS inhibitor; …
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Paracoccus denitrificans as a model system for studying the mechanism of respiratory complex I
Respiratory complex I (NADH:ubiquinone oxidoreductase) is a crucial metabolic enzyme that couples the free energy released from NADH oxidation and ubiquinone reduction to the translocation of four protons across an energy-transducing membrane, contributing to the proton motive force used to …
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Molecular Characterisation and Therapeutic Targeting of NPM1-mutant Acute Myeloid Leukaemia
… displayed increased basal and maximal mitochondrial respiration and enhanced sensitivity to mitochondrial complex I inhibitors. Furthermore, inhibition of the mitochondrial polymerase POLRMT preferentially reduced the proliferation of NPM1c+ AML cells and synergised with Venetoclax to …
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Integrative multiomic insights into Alzheimer’s disease pathology
… a component of vitamin B, is essential for both mitochondrial bioenergetics and DNA repair through NAD<sup>+</sup>-consuming poly (ADP-ribose) polymerases (PARPs). I found that increasing the bioavailability of NAD<sup>+</sup> pharmacologically or by suppressing PARP is neuroprotective in fly …
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Tetrahydroisoquinoline Neurotoxins in Parkinson Disease
… supply, caused in particular by inhibition of mitochondrial complex I. Their concentration in dopaminergic regions of human brain and relatively potent cytotoxicity among TIQs makes these compounds strong candidates for both an endogenous and exogenous link to cell death in PD. </p>
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ROLE OF ENDOTHELIN-1 IN THE REGULATION OF THE SWELLING-ACTIVATED Cl- CURRENT IN ATRIAL MYOCYTES
… in cardiomyocytes. Blocking NOX with apocynin or mitochondrial complex I with rotenone both completely suppressed ET-1-induced ROS generation and activation of ICl,swell, indicating that ROS from both NOX and mitochondria were required to activate ICl,swell, and complete block by inhibitors of …
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