Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Mitochondrial carriers"”.
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Functional and mechanistic studies of human mitochondrial carriers
The SLC25 mitochondrial carrier family is the largest family of transporters, with 53 members in humans. They selectively transport a diverse set of substrates across the mitochondrial inner membrane, and are involved in key aspects of mitochondrial metabolism and function. The identification and …
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Comparative phylogenetic exploration of the human mitochondrial proteome: Insights into disease and metabolism
… from ATP synthesis to apoptosis. Changes in mitochondrial function are associated with many diseases, as well as ‘natural’ processes like ageing. Mitochondria have a unique evolutionary origin, as the result of an endosymbiotic relationship between a bacterium and an archaeal cell. Therefore, …
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Molecular Mechanisms of Gating, Selectivity, and Transport in Membrane Channels and Carriers
… materials, specialized membrane channels and carriers have been evolved to facilitate their transport across biological membranes. The water channel aquaporin (AQP) and the nucleotide transporter ADP/ATP carrier (AAC) are the focus of the research presented in this thesis. By facilitating …
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The role of mitochondrial transporters in human physiology and adverse drug effects
… prescribed medications often cause off-target mitochondrial dysfunction, but the underlying molecular mechanisms are largely unknown. Mitochondrial transport proteins form a significant class of potential off-targets that remain largely unexplored. The main aim of this thesis is to evaluate the …