Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Mitochondrial carrier"”.
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Metabolic gatekeepers – Deciphering the mitochondrial carrier family in malaria parasites
Contains fulltext : 323971.pdf (Publisher’s version ) (Open Access)
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Functional and mechanistic studies of human mitochondrial carriers
The SLC25 mitochondrial carrier family is the largest family of transporters, with 53 members in humans. They selectively transport a diverse set of substrates across the mitochondrial inner membrane, and are involved in key aspects of mitochondrial metabolism and function. The identification and …
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Mitochondrial ATP production and energy-buffering in the human pathogen Trypanosoma brucei
… Trypanosoma brucei. ATP is produced in the mitochondrial matrix from ADP and inorganic phosphate by substrate-level and oxidative phosphorylation. To maintain the cellular energy provision, ATP has to be exported from the mitochondrial matrix, and ADP and Pi imported from the cytosol. This …
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Identification and functional characterization of the mitochondrial adenine nucleotide carriers of Trypanosoma brucei
The Mitochondrial Carrier Family encloses a group of transmembrane proteins that transport metabolites across the mitochondrial inner membrane. The ADP/ATP carrier is the most widely studied MCF protein. It catalyzes the counter exchange of ADP for ATP in the mitochondrion of all eukaryotes. In the …
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Identification and analysis of Arabidopsis thiamine pyrophosphate transporters
… enzymes. In Arabidopsis, two members of the mitochondrial carrier family (MCF), AtTpc1 and AtTpc2, export TPP to the mitochondria, but the chloroplast TPP carrier is still unknown. This project aims to identify thiamine chloroplast transporter(s) and investigate mitochondrial thiamine …
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Development of pseudosymmetry analysis to identify key residues in transport protein mechanisms
… three major superfamilies of transporter: the mitochondrial carrier family, the major facilitator superfamily, and the amino acid polyamine organocation superfamily. The software is then tested on transporters for which there is a large amount of experimental data to test the effectiveness of …
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The evolution of freeze tolerance in a historically tropical snail
… of Mexico. I have used sequence data from one mitochondrial (CO1) and two nuclear markers (histone H3 and a mitochondrial carrier protein, MCP) to identify three cryptic species within Melampus bidentatus, and to infer their relationships to other Melampus. To identify microhabitat differences …
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Mitochondrial protein SFXN3 as a novel target in neurodegenerative diseases
… and Sideroflexin 3 (SFXN3) was identified as a mitochondrial protein that modulates synaptic morphology in vivo. This finding prompted the aims of this thesis: biochemical characterisation of SFXN3; the identification of SFXN3’s molecular interactors and the investigation of its role in …
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Structure and regulatory mechanism of human uncoupling protein 1
Uncoupling protein 1 (UCP1) in the mitochondrial inner membrane is responsible for the thermogenic properties of brown adipose tissue. In response to cold exposure, UCP1 is activated by free fatty acids and catalyses proton leak, dissipating the proton motive force, which mitochondria use to drive …
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An investigation of the mechanisms of piperaquine resistance in Plasmodium falciparum malaria
… exonuclease protein (exo-E415G) and a putative mitochondrial carrier protein (mcp-N252D). This research fills a knowledge gap in the lack of functional data for molecular markers of piperaquine resistance by examining the phenotypic relevance of the genotypes observed in contemporary isolates. …
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DISSECTING THE ROLE OF NEDD4 HECT E3 LIGASE AND ITS ISOFORMS IN CANCER
… NEDD4 isoform 3 interactors, of which the mitochondrial carrier SLC25A13. To date, significant observations linking NEDD4 E3 ligase to mitochondria are not reported, thus the functional relevance arising from this interaction was explored. In this context, the observed mitochondrial …
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The role of mitochondrial transporters in human physiology and adverse drug effects
… prescribed medications often cause off-target mitochondrial dysfunction, but the underlying molecular mechanisms are largely unknown. Mitochondrial transport proteins form a significant class of potential off-targets that remain largely unexplored. The main aim of this thesis is to evaluate the …
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Functional characterisation of the human mitochondrial ATP-Mg/Pi carriers and their disease-causing variants
The mitochondrial ATP-Mg/Pi carriers (APCs) catalyses the exchange of adenine nucleotides for phosphate across the mitochondrial inner membrane, which is regulated by calcium. They are responsible for modulating the adenine nucleotide pool in the mitochondrial matrix, and therefore have a pivotal …