Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Mitochondrial biology"”.
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Mitochondrial Biology in Sporadic Inclusion Body Myositis
… that triggers an inflammatory/ immune response. Mitochondrial abnormalities have been observed in skeletal muscle from patients diagnosed with the disease, however the role of the mitochondria in disease pathology is still unclear. The aim of this dissertation was to evaluate: 1) the role of the …
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The Role of FBXO7 in Mitochondrial Biology and Parkinson's Disease
… My experiments showed that these cells also had mitochondrial respiration defects, exhibiting lower basal respiration, ATP production, maximal respiration and spare capacity, in addition to complex I, III and IV deficiencies. Patient fibroblasts also had significantly lower levels of 12S and 16S …
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Investigating mitochondria alterations in esophageal pathologies
… malignant pathologies. Recently, metabolic and mitochondrial dysfunction have been implicated in EoE pathogenesis. However, there is a need to define the influence of EoE-associated inflammatory cues upon mitochondrial biology, mechanisms mediating these effects and the clinical significance of …
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A Multi-omics Study of Human Mitochondrial Proteins During Neurogenesis
… play vital roles in neurogenesis. Disruptions of mitochondrial functions may lead to neurodegenerative disorders. Yet, the underlying mechanisms remain largely unknown. To elucidate the dynamic changes of transcriptomes during neurogenesis, the single cell RNA sequencing experiments were conducted …
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The Role of UCP2 in Pancreatic Cancer Metabolism and Its Potential as a Radiosensitizer
<p>Uncoupling protein 2 (UCP2) is a mitochondrial protein that regulates the flow of protons down the gradient established by the electron transport chain (ETC) without generating ATP, thus uncoupling the proton gradient from ATP generation. In tumors, specifically pancreatic cancer (PDAC), the ETC …
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Reorganization of mitochondrial architecture during apoptosis and mitophagy as investigated by correlative microscopy
… microscopy to investigate reorganization of mitochondrial architecture during two processes, apoptosis and mitophagy, in an effort to better understand the contribution of membrane remodeling to these biological processes. During apoptosis, Bax/Bak oligomerize and accumulate in and adjacent …
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New Roles for Mitochondria in Shaping Antiviral and Stress Responses
… to counteract invading pathogens like viruses. Mitochondrial functions are central to a variety of antiviral responses including apoptosis and type I interferon signaling (IFN-I). While apoptosis and IFN-I mediated by Mitochondrial AntiViral Signaling (MAVS) are well-established defenses, new …
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Interactions with bioenergetics by the mitochondria-targeted anti-apoptotic imidazole fatty acid derivative ‘TPP-IOA’.
The mitochondrial pathway of apoptosis contributes to cell death and tissue degeneration in a variety of human diseases. Targeting the molecular events of this pathway represents a promising therapeutic strategy under pathological scenarios, particularly in tissues with limited regenerative …
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Computer modelling of metabolic adaptions during mitochondrial dysfunction and machine learning to predict novel mitochondrial disease genes
… This thesis investigates two main causes of mitochondrial dysfunction: mitochondrial toxicity arising from side-effects of drugs; and mitochondrial diseases arising from defects in nuclear-encoded genes. Novel chemical entities being developed as drug leads are screened for cellular toxicity …
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Disruption of mitochondrial redox homeostasis as a cellular signal.
… to disentangle the overlapping effects of mitochondrial ROS signalling compared to a redox signal stemming from disruption of mitochondrial thiol homeostasis. Furthermore, it is important to distinguish between disturbing the cytosolic and mitochondrial protein antioxidant systems. I …
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Nutrient and Stress-Induced Mitochondrial Hyperfusion Regulates Cell Death Pathways
… of membrane fission and fusion to maintain mitochondrial genome integrity and levels of oxidative phosphorylation. Mitochondria have been shown to shift the balance of these two opposing pathways to drive a hyperfusion response following proteostasis stress conditions to avoid apoptosis. …
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CHCHD2 and the tumor microenvironment in glioblastoma
… tumors has expanded understanding of brain tumor biology, targeted therapies against cellular pathways affected by the most common genetic aberrations have been largely ineffective at producing robust survival benefits. Currently, a major obstacle to more effective therapies is the impact of the …
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Origin, evolution, and global spread of a transmissible cancer clone
… I profile global tumour diversity using complete mitochondrial genome sequences (mtDNA) from 449 CTVT tumours collected from 39 countries in the first large-scale examination of CTVT clonal diversity. Phylogenetic characterisation of this clonal lineage showed that CTVT has captured mtDNA from …