Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Mitochondrial apoptosis"”.
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The role of the retinoblastoma protein in mitochondrial apoptosis
… Importantly, pRB also plays a pivotal role in apoptosis. This function has been extensively characterized in the context of genotoxic stress. Specifically, these studies have revealed that pRB can act in both an anti-apoptotic manner by inducing cell cycle arrest, and a pro-apoptotic manner by …
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Mechanisms of BAK Activation in the Initiation of Mitochondrial Apoptosis
<p>Mitochondrial apoptosis is crucial for normal mammalian development and adult homeostasis being regulated by B-Cell Lymphoma-2 (BCL-2) proteins. Deregulation of BCL-2 proteins form the basis for myriad of human pathologies including cancer and autoimmune diseases. Therefore, BCL-2 proteins are …
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The Role of Peroxiredixin Ⅲ in the ototoxic drug-induced mitochondrial apoptosis of cochlear hair cell
Apoptosis is essential during development and for maintenance of healthy tissues. Dysregulation of apoptosis has thus been found to contribute to many pathologies, including neurodegenerative disorders, as well as to tumor promotion. Normal cellular processes that involves oxygen result in the …
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Human telomerase reverse transcriptase (hTERT) overexpression modulates intracellular redox balance and protects cancer cells from apoptotic cell death
… form. Our data also provide evidence for mitochondrial localization of hTERT, and a significantly higher activity of cytochrome c oxidase, the rate-limiting enzyme in the mitochondrial electron transport chain, in hTERT overexpressing cells. To ascertain whether the improved mitochondrial …
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Insights into the Functional Link between MtHsp40:MtHsp70 Network and Mitochondrial Homeostasis
Mitochondrial apoptosis, morphology and function can be modulated by the activity of mitochondrial chaperones including mtHsp40 and mtHsp70. We found that both overexpression and depletion of mtHsp40 reversibly changed mitochondrial morphology from tubular network to fragmented puncta, in a process …
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A Novel Cardiac Function of Sumo2/3 and Senp5 Dependent Pathway and Its Physiological Impact On Congestive Cardiomyopathy
… cell cycle, protein stability, and apoptosis. Although SUMO1 has been extensively studied so far, relevance of SUMO2/3 is unclear, especially in heart. Here we show that failing heart induces SUMO2/3 conjugation. Increased SUMO2/3-dependent modification leads to congestive heart …
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Rapid turnover of McL-1 couples translation to cell survival and apoptosis
… of translation contributes to the induction of apoptosis by various cell stimuli including inhibition of PI 3-kinase/Akt survival signaling, viral infection, lipopolysaccharide, and tumor necrosis factor alpha. However, the mechanism by which translation inhibition promotes apoptosis has not …
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Targeting Apoptotic Pathways to Overcome Drug Resistance In Acute Myeloid Leukemia
<p>Evasion of apoptosis is integral to tumorigenesis and drug resistance. BCL-2 and p53 proteins represent two focal nodes in convergent apoptosis signaling. Upregulation of anti-apoptotic BCL-2 family members and inactivation of p53 functions are two canonical approaches exploited by cancer cells …
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Regulation of BAX/BAK-Dependent Cell Death Program
… a critical checkpoint in mitochondrion-dependent apoptosis. Multidomain proapoptotic BAX/BAK promotes mitochondrial outer membrane permeabilization, whereas anti-apoptotic BCL-2/BCL-X<sub>L</sub>/MCL-1 protects mitochondrial integrity and prevents cytochrome c release. The proapoptotic activity of …
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Delineating the Steps of BAX Pore Activation
… BCL2 protein family is the primary gatekeeper of mitochondrial apoptosis and governs integrity of the organelles' outer membranes. Permeabilization of mitochondrial outer membranes permits egress of cytochrome c and other apoptogenic factors, resulting in apoptosome formation, caspase activation, …
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Study of Regulated Cell Death In Two Systems: Pd-1 In Natural Killer Cells and Rip3 In Neurons
… kinase domain-like pseudokinase (MLKL) and mitochondrial apoptosis-inducing factor (AIF). Inhibiting RIP3 by an FDA approved anti-cancer drug, dabrafenib, reduced both acid-induced death of mouse cortical neurons <em>in vitro</em> and brain infarction in mice subjected to middle cerebral …
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Effects of Ubiquinol with Fluid Resuscitation following Hemorrhagic Shock
… are known to activate the intrinsic pathway of apoptosis and contribute to organ dysfunction.1 Ubiquinol is a potent free radical scavenger which is produced endogenously and functions as part of the mitochondrial respiratory chain.2 No study has been conducted to investigate the effects of …