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Showing 1 to 13 of 13 for “"Mitochondrial Uncoupling"”.
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Evaluating mitochondrial uncoupling potentials of A7E and DNP in Saccharomyces cerevisiae : implications for human obesity
… death. Weight loss supplements frequently claim uncoupling as a mechanism of action. Uncoupling agents could be used for weight loss because they disrupt mitochondrial metabolism thereby reducing adenosine triphosphate (ATP) yield. Consequently, metabolic efficiency diminishes increasing basal …
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FoxO1 in the regulation of adipocyte autophagy and biology
… adipocytes; and (2) to differentially regulate mitochondrial uncoupling proteins (UCP) that have been implicated in browning of white adipose tissue and redox homeostasis. Mechanistically, FoxO1 appears to induce autophagy through the transcription factor EB (Tfeb), which was previously shown to …
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Biochemical Studies on Uncoupling Proteins and Glucose Metabolism in Skeletal Muscle
Uncoupling protein (UCP) is an inner-mitochondrial membrane protein that uncouples the production of ATP from the electron transport chain, thereby inducing thermogenesis. Recently, a family of UCP homologues was identified, two of which (UCP-2 and UCP-3) are highly expressed in skeletal muscle. …
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Complex Heterocycles as Mitochondrial Uncouplers
Small molecule mitochondrial uncouplers are compounds that dissipate the proton motive force independent of ATP synthase that results in increased energy expenditure. Mild mitochondrial uncoupling has therapeutic potential in treating obesity, diabetes, neurological diseases, non-alcoholic …
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Mitochondrial Uncouplers: Development as Therapeutics for Metabolic Diseases
… by passively shuttling protons from the mitochondrial inner membrane space into the mitochondrial matrix. Mitochondrial uncoupling results in the disruption of the proton motive force leading to an upregulation of metabolism (i.e., decrease in steatosis). Small molecule mitochondrial …
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The effect of 10 days of heat acclimation on submaximal exercise economy and efficiency at 1600 m and 4350 m
… significantly reduced UCP3 expression, reduced mitochondrial uncoupling (71.1% ±1.2%) and suppressed basal and peak oxidative metabolism (75.5% ± 4.9% and 64.4% ± 5.9%, respectively) compared to control. Heat stress also significantly increased PGC-1α, NRF1 and TFAM leading to increased …
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Acute hypoxia-induced diaphragm dysfunction is prevented by antioxidant pre-treatment
… by acute hypoxia, and gene expression driving mitochondrial uncoupling was increased. Acute hypoxia increased atrophic signalling, but not proteasome activity. Acute hypoxia increased hypertrophic and hypoxia protein signalling. NAC pre-treatment prevented the acute hypoxia-induced diaphragm …
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Structure-Activity Relationship Studies of Imidazo[4,5-b]pyrazine Derivatives as Mitochondrial Uncouplers and their Potential in the Treatment of Obesity
Mitochondrial uncouplers have the capacity of passively shuttling protons from the mitochondrial intermembrane space to the mitochondrial matrix, independent of ATP synthase. This results in the disruption of oxidative phosphorylation and increased rate of metabolism as a counter action from the …
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The role of Toll-like Receptor 4 in the Modulation in Skeletal Muscle Metabolism
… to deceased fatty acid oxidation and altered mitochondrial respiration in skeletal muscle. To this end, skeletal muscle cells were studied following acute and chronic treatments with LPS, and a mouse model with muscle-specific over expression of TLR4 (mTLR4) was studied under chow fed …
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Structure-Activity Relationship Studies of Sphingosine Kinase Inhibitors and Mitochondrial Uncouplers
… in vivo activity will also be discussed. Mitochondrial uncouplers are small molecules that shuttle protons from the inter membrane space to the mitochondrial matrix independent of ATP synthase, which disrupts oxidative phosphorylation and promotes increased nutrient metabolism for …
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The Role of Secretory Phospholipase A2 Group IIA in Obesity and Metabolism
… fat mass. There was a significant induction of uncoupling protein 1 (UCP1) in the brown adipose tissue (BAT) of IIA+ mice, suggesting enhanced mitochondrial uncoupling in their adipose tissue to drive this metabolic phenotype. Previous work in Dr. Park’s laboratory suggested that hepatic PLA2G2A …
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Structure-Activity Relationship Studies of Mitochondrial Uncouplers and PilB Inhibitors
… limited side effects is thus desirable. Chemical mitochondrial uncouplers are protonophoric, lipophilic small-molecules that transport protons from the mitochondrial intermembrane space into the matrix independent of ATP synthase, thus uncoupling nutrient oxidation from ATP production. Such a …