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Showing 1 to 10 of 10 for “"Mitochondrial Uncouplers"”.
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Complex Heterocycles as Mitochondrial Uncouplers
Small molecule mitochondrial uncouplers are compounds that dissipate the proton motive force independent of ATP synthase that results in increased energy expenditure. Mild mitochondrial uncoupling has therapeutic potential in treating obesity, diabetes, neurological diseases, non-alcoholic …
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Mitochondrial Uncouplers: Development as Therapeutics for Metabolic Diseases
… by passively shuttling protons from the mitochondrial inner membrane space into the mitochondrial matrix. Mitochondrial uncoupling results in the disruption of the proton motive force leading to an upregulation of metabolism (i.e., decrease in steatosis). Small molecule mitochondrial …
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Structure-Activity Relationship Studies of Mitochondrial Uncouplers and PilB Inhibitors
… limited side effects is thus desirable. Chemical mitochondrial uncouplers are protonophoric, lipophilic small-molecules that transport protons from the mitochondrial intermembrane space into the matrix independent of ATP synthase, thus uncoupling nutrient oxidation from ATP production. Such a …
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Structure-Activity Relationship Studies of Sphingosine Kinase Inhibitors and Mitochondrial Uncouplers
… in vivo activity will also be discussed. Mitochondrial uncouplers are small molecules that shuttle protons from the inter membrane space to the mitochondrial matrix independent of ATP synthase, which disrupts oxidative phosphorylation and promotes increased nutrient metabolism for …
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Design and Synthesis of Mitochondrial Uncouplers for the Treatment of Mitochondrial Dysfunction
Within the body, mitochondrial has a leading role in many cellular functions including energy production and cell signaling. When mitochondria become dysfunctional diseases such as obesity, type II diabetes mellitus, and metabolic dysfunction-associated steatohepatitis can occur. Mitochondrial …
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Design and Synthesis of 8-Trifluoromethyl-Substituted Heterocyclic Small Molecule Mitochondrial Uncouplers for the Treatment of Metabolic Diseases
… converted into energy through a process called mitochondrial respiration. Through this process, mitochondria provide over 90% of cellular energy. However, during inflammatory events, mitochondrial respiration is less efficacious and could cause or progress diseases such as obesity, type 2 …
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Structure-Activity Relationship Studies of Imidazo[4,5-b]pyrazine Derivatives as Mitochondrial Uncouplers and their Potential in the Treatment of Obesity
Mitochondrial uncouplers have the capacity of passively shuttling protons from the mitochondrial intermembrane space to the mitochondrial matrix, independent of ATP synthase. This results in the disruption of oxidative phosphorylation and increased rate of metabolism as a counter action from the …
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Discovery of small-molecule natural products that target cellular bioenergetics
… enhance the effectiveness of current therapies. Mitochondrial oxidative phosphorylation inhibitors in botanical dietary supplements (BDS) possess a potential health hazard which should be identified and appropriately regulated. Chapter one briefly reviews the molecular-targeted natural product …
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A Human Pluripotent Stem Cell-Derived Model for the Investigation of Thermogenic Adipocyte Development and Function
… side effects, as previous strategies involving mitochondrial uncouplers or sympathomimetic drugs have been unsafe and associated with cardiovascular problems due to increased sympathetic activation. Other mechanisms of BAT activation must thus be identified. In the quest to increase …
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Exploring Parkinson’s disease associated LRRK2 and PINK1/Parkin signal transduction pathways within immune cells
… blood neutrophils and treated them with the mitochondrial uncoupler CCCP for durations of 3-20 hours, and analysed neutrophil lysates for PINK1 stabilisation through immunoblotting with the PINK1 (Novus) antibody. I also conducted PINK1 immuno-precipitation (IP) experiments to confirm the …