Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Mitochondrial Sirtuins"”.
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Regulation of Mitochondrial Sirtuins Sirt3 and Sirt5 by Small Molecules
Sirtuins are a highly conserved family of protein deacylases that are important regulators of metabolism, longevity and aged-related diseases. There are seven sirtuin isoforms in mammals with different subcellular localization, substrates and biological functions. Three sirtuin isoforms, Sirt3-5, …
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Protective effect of Nicotinamide on High glucose (HG)/Palmitate (PA)-induced Glucolipotoxicity to INS-1 beta cells
… has protective effect through inhibition of mitochondrial Sirt3 and Sirt4 in HG/PA-induced INS-1 beta cell death.
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TUMOR PROMOTING FUNCTIONS FOR THE METABOLIC REGULATOR SIRT5
… in carcinogenesis. In mammals there are three mitochondrial sirtuins, SIRT3, SIRT4, and SIRT5. Among these, SIRT5 is the only known enzyme that catalyzes nicotinamide adenine dinucleotide-dependent demalonylation, desuccinylation and deglutarylation. SIRT5 impacts diverse metabolic pathways. …