Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"Mitochondrial Proteins"”.
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The alternative evolutionary fates of mitochondrial proteins
Contains fulltext : 178927.pdf (Publisher’s version ) (Open Access)
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A Multi-omics Study of Human Mitochondrial Proteins During Neurogenesis
… play vital roles in neurogenesis. Disruptions of mitochondrial functions may lead to neurodegenerative disorders. Yet, the underlying mechanisms remain largely unknown. To elucidate the dynamic changes of transcriptomes during neurogenesis, the single cell RNA sequencing experiments were conducted …
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ECLIPSED DUAL DISTRIBUTION OF MITOCHONDRIAL PROTEINS IN EUKARYOTES: UBIQUITINATION IN YEAST MITOCHONDRIA AS A PARADIGM
… Pines' lab demonstrate that dual targeting of mitochondrial proteins is a highly abundant phenomenon using Saccharomyces cerevisiae as the model organism. The studies of the present thesis indicate that a significant fraction of cellular proteins, much more than previously assumed, are eclipsed …
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Mitochondrial Calcium Uptake: LETM1 and MICU1 Are Mitochondrial Proteins That Regulate Mitochondrial Calcium Homeostasis and Cellular Bioenergetics
Mitochondrial calcium (Ca2+) uptake has been studied for over five decades, with crucial insights into its underlying mechanisms enabled by development of the chemi-osmotic hypothesis and appreciation of the considerable voltage present across the inner mitochondrial membrane (ΔΨm) generated by …
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Mitochondrial Protein Expression in Natural and Induced Forms of Canine Dilated Cardiomyopathy
In conclusion, mitochondrial proteins associated with essential metabolic pathways were found to be altered in the myocardium of dogs with DCM. The altered mitochondrial proteins were mainly related to oxidative phosphorylation, but also included other elements of primary energy and other types of …
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Adrenergic control of proteolysis in brown adipocytes
… result in tissue atrophy by loss of cells, mitochondrial proteins, and uncoupling protein 1 (UCP1), the molecular basis for thermogenesis. The overall objective is to gain a better understanding of the control and the mechanisms underlying BAT atrophy. Specific objectives are: (1) whether in …
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Function and inhibition of the mitochondrial O-GlcNAc transferase isoform
… to serine and threonine residues of target proteins. It is abundant in metazoa, involving hundreds of proteins linked to a plethora of biological functions with implications in human diseases. The process is catalysed by two enzymes, O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), that add …
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PKCε and cardioprotection : an exploration of putative mechanisms
… interactions between activated PKCε and various mitochondrial proteins, which orchestrate mitochondrial homeostasis, including proteins governing mitochondrial oxidative phosphorylation, electron transfer, ion transport and control of mitochondrial permeability transition (MPT). MPT disruption is …
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Comparative phylogenetic exploration of the human mitochondrial proteome: Insights into disease and metabolism
… from ATP synthesis to apoptosis. Changes in mitochondrial function are associated with many diseases, as well as ‘natural’ processes like ageing. Mitochondria have a unique evolutionary origin, as the result of an endosymbiotic relationship between a bacterium and an archaeal cell. Therefore, …
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Directed evolution of TurboID for efficient proximity labeling in living cells and organisms
… the spatial and interaction characteristics of proteins in which a PL enzyme can be genetically targeted to a subcellular region and used to tag surrounding endogenous proteins with a chemical handle that allows their identification by MS. Tagging is carried out in living cells in a …
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Development of a chemical biology approach for glycoprotein discovery in Caenorhabditis elegans reveals glycosylated isoforms of multiple proteins with mitochondrial function
… the cellular pathways that produce glycoproteins and the functional roles these glycoproteins play within the cell depends on having an adequate quiver of experimental approaches available. Together with my dissertation advisor, Dr. Patricia Berninsone and the assistance of excellent …
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Hibernation is super complex: dynamics of electron transport system supercomplexes
… complexes form supercomplexes (SCs) within mitochondrial membranes, perhaps increasing respiratory capacity or reducing reactive oxygen species production. My project aimed to determine the abundance, composition, and stability of SCs in a hibernator. Hibernators have dynamic metabolisms …
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VDAC and SOD1: two major players in mitochondrial metabolism and in ALS
… work presented here has been devoted to two proteins, the Voltage-Dependent Anion Channel (VDAC) and the Superoxide Dismutase I (SOD1) and has been especially focused on the relationships between them in physiological or pathological conditions of the cell. VDAC is a pore-forming protein …
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Yeast Ataxin-2, A Protein with Many Friends: Identification of a Novel Role for Pbp1 in Mitochondrial Biogenesis
… a respiratory environment forces the cell to use mitochondrial respiration, and as a result, mitochondrial biogenesis is induced. Puf3 functions as a glucose sensor in yeast to support mitochondrial biogenesis in respiratory conditions. It facilitates a rapid stabilization of its target …
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Proteomic analysis of cellular models of neurodegeneration and mitochondrial dysfunction
Mitochondrial dysfunction is thought to contribute to neurodegenerative processes. As an example, dysfunction of complex I of the electron transport chain has been observed in Parkinson’s disease patients and 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP), a complex I inhibitor, produces a …
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Mitochondrial Dysfunction: A Mechanistic Link in the Progression from Normal Aging to Sporadic Alzheimer’s Disease
… are crucial for synaptic physiology, and mitochondrial dysfunction, especially of synaptic mitochondria, has been widely recognized as a hallmark pathological feature in both normal aging and sporadic Alzheimer’s disease (AD). Aging and sporadic AD are closely linked, with aging …
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Mitochondrial parts, pathways, and pathogenesis
… metabolism, ion homeostasis, and apoptosis. Mitochondrial dysfunction causes disease in 1 in 5,000 live births and also has been associated with aging, neurodegeneration, cancer, and diabetes. To systematically explore the function of mitochondria in health and in disease, it is necessary to …
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Cardiolipin Regulates Mitophagy Through The Pkc Pathway
… (CL), the signature phospholipid of mitochondrial membranes, is important for cardiovascular health. Perturbation of CL metabolism is implicated in cardiovascular disease (CVD). The link between CL and CVD may be explained by the physiological roles of CL in pathways that are …
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A Novel Cardiac Function of Sumo2/3 and Senp5 Dependent Pathway and Its Physiological Impact On Congestive Cardiomyopathy
… SUMO2 targets have been known to be involved in mitochondrial-independent cell death pathway in heart. These SUMOylations of Calpain2 and Calpastatin facilitate activation of Calpain2 by reducing inhibitory role of Calpastatin. These findings identify a SUMO2/3-dependent modification as a novel …
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Enzyme-based reporters for mapping proteome and imaging proteins in living cells
… functions are uniquely defined by the set of proteins they possess. For each individual protein, precise targeting to a specific sub-cellular location and trafficking between compartments are often key to its proper function. In fact, many human diseases are linked to mutations that cause …
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