Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Mitochondrial Protein Synthesis"”.
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Effect of aflatoxin on mitochondrial transcription and translation
The effect of aflatoxin B₁ on RNA synthesis in phosphate-swollen rat liver mitochondria was examined. In the assay system used the incorporation of ³H-UTP into acid-insoluble product was inhibited 52% by actinomycin D (50µg/ml) and the labeled product was sensitive to pancreatic RNase. Aflatoxin B₁ …
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The Effect of Leucine Supplementation on Biomarkers of Mitochondrial Biogenesis and Protein Synthesis in Soleus Muscle of Rats Fed a High-Fat Diet
<p>Mitochondrial dysfunction is a contributing factor to the advancement of various diseases including obesity, diabetes, and cardiovascular disease. Impairment in mitochondria brings about a diminished mitochondrial number and oxidative capacity. Leucine is known to stimulate muscle protein …
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Modelling neuronal mitochondrial aminoacyl-tRNA synthetase defects
Mitochondrial diseases cover a broad group of disorders caused by mitochondrial dysfunction, often affecting organs with high metabolic demand, such as the brain and skeletal muscle. Mutations in mitochondrial aminoacyl-tRNA synthetase (MT-ARS) genes, which are crucial for mitochondrial protein …
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RNA-binding proteins in yeast mitochondria
… of which have been identified as RNA-binding proteins without known RNA recognition motifs. Besides analysing their effects on mitochondrial translation and their organisation in protein complexes the work focused on the characterisation of the RNA-binding properties of recombinant Cit1p and …
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Mitochondrial Contributions to Schizophrenia Symptom Severity: A GWAS Approach in a South African Population
… this study investigated the contribution of mitochondrial genomic variation and mitonuclear crosstalk to clinical symptom severity in a South African First Episode Schizophrenia (FES) cohort (N=103). Utilizing genome-wide association data, the study employed General Linear Models to assess …
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Human obesity and its influence on muscle protein synthesis
… for high throughput of macronutrients, damaged proteins must be degraded and replaced on a continual basis. Moreover, amino acids from meals are crucial for the muscle to replace those lost for other needs (e.g. gluconeogenesis and oxidation). Skeletal muscle appears to be more responsive to …
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Defining the cellular and molecular mechanism of maternally inherited hearing loss
Mitochondrial dysfunction causes moderate to profound hearing loss both in isolation and as a feature of multi-systemic mitochondrial disease. The m.1555A>G mitochondrial DNA (mtDNA) variant is associated with a predisposition to aminoglycoside ototoxicity and maternally inherited non-syndromic …