Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"Mitochondrial Fission"”.
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Mitochondrial Fission After Traumatic Brain Injury
<p>Mitochondrial dysfunction is a central feature in the pathophysiology of Traumatic Brain Injury (TBI). Loss of mitochondrial function disrupts normal cellular processes in the brain, as well as impedes the ability for repair and recovery, creating a vicious cycle that perpetuates damage after …
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Burn Serum Stimulates Mitochondrial Fission in C2C12 Myoblasts
… with a hypercatabolic status. Impairment of mitochondrial function has been observed in the muscle of burn patient's. OBJECTIVE: We hypothesize that muscle atrophy due to burn injur y is associated with an alteration in mitochondrial dynamics. This study was designed to investigate changes in …
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The Roles of Midzone and Peripheral Mitochondrial Fission in Pulmonary Arterial Hypertension
Mitochondrial fission is vital for maintaining mitochondrial health, regulating cellular processes like proliferation and apoptosis. Disrupted fission is associated with development of cardiovascular diseases, including pulmonary arterial hypertension (PAH), ischemia-reperfusion injury, cardiac …
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Investigating a Mitochondrial Fission Inhibitor as a Therapeutic for Inflammatory Bowel Diseases
Unbalanced mitochondrial dynamics exacerbates inflammation and is of interest for its possible role in the pathogenesis of inflammatory bowel disease (IBD). The current study utilized the P110 peptide drug, a selective inhibitor of mitochondrial fission, to investigate the relationship between …
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Preclinical Investigation of Mitochondrial Fission Inhibitors in Pulmonary Arterial Hypertension and Non-Small Cell Lung Cancer
… Dynamin-related protein 1 (DRP1)-mediated mitochondrial fission is coordinated with nuclear division. This phenomenon, known as mitotic fission, is increased in hyperproliferative diseases, such as non-small cell lung cancer (NSCLC) and pulmonary arterial hypertension (PAH), due to …
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Effects of loigomycin, F0/F1 ATP-synthase inhibitor on mitochondrial morphology and dynamics
Mitochondrial fission has recently been well-recognized as a factor involved in apoptosis although its role and the underlying mechanism remains unclear. Recently, we monitored the effects of mitochondrial respiratory inhibitors [rotenone, TTFA (2-thenoyltrifluoro-acetone), antimycin A, and …
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MITOCHONDRIA FACILITATE VASCULAR INFLAMMATION: THE ROLE OF CANONICAL INFLAMMATORY SIGNALING IN THE REGULATION OF MITOCHONDRIAL MORPHOLOGY
… inflammatory based diseases are associated with mitochondrial dysfunction and morphological alterations, the direct mechanisms tying the mitochondria to canonical NF-κB signaling remain elusive. Using pharmacological and genetic approaches, we show inflammatory-mediated mitochondrial fission, …
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Mitochondrial Dynamics Imbalance as a Potential Driver of Neuronal Decline in the Aging Nervous System of Lymnaea stagnalis
… decline has become increasingly important. Mitochondrial dysfunction has long been implicated in the aging process, as neurons rely heavily on mitochondrial metabolism to meet their high energetic demands. However, the specific mechanisms through which mitochondrial dysfunction contributes …
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Characterisation of new factors regulating mitochondrial dynamics and cellular metabolism
… behaviour depends on continuous cycles of fission or fusion, which is mediated by large GTPase enzymes, facilitating the remodelling of the network to adapt and answer to cellular needs. However, the underlying molecular details of these events have not been fully elucidated. Recently, the …
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Mitochondrial Dynamics: Exploring A Novel Target Against Myocardial Ischemia-Reperfusion Injury
<p>Mitochondrial fusion and fission, collectively termed mitochondrial dynamics, are among the core mechanisms responsible for maintaining mitochondrial health and functional integrity. Dynamin-related protein 1 (DRP1) is a key regulator of mitochondrial fission. Recent studies suggest that i) …
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Molecular Architecture of the ER-Mitochondria Encounter Structure
… ERMES is important for the maintenance of mitochondrial morphology and is implicated in the process of mitochondrial fission. ERMES organises as diffraction limited foci between the ER and mitochondria; however, the molecular architecture of ERMES components within these foci is unknown. …
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Mitochondrial response to axonal injury
… to injury. A viral vector (AAV) containing a mitochondrially targeted fluorescent protein (mitoDsRed) as well as fluorescently tagged LC3 (GFP-LC3), an autophagosomal marker, was injected into primary motor cortex, to label the corticospinal tract (CST), of adult rats. The axons of the CST …
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Mitochondrial structure and distribution in Saccharomyces cerevisiae
… division. The structure of the highly dynamic mitochondrial network is adjusted to fit cellular needs by orchestrating mitochondrial movement, fusion, and fission. All three processes are important for the maintenance of functional mitochondria. The core components of the transport, fusion, and …
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Mitochondrial dynamics in the radiation response of cancer cells
… that determine the response of cells to damage. Mitochondrial fission and fusion are associated with cell cycle regulation, apoptosis, cellular bioenergetics and redox status, which contribute to cellular homeostasis and damage response. The study aimed to describe and correlate cancer cell …
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The role of mitochondria in regulating smooth muscle cell proliferation and migration in pulmonary hypertension
… unclear. Recent studies highlight the role of mitochondrial alteration in PASMC of pulmonary hypertension, which is characterized by the glycolysis shift in metabolism and the increase in mitochondrial fragmentation that is also observed in cancer.The work presented in this thesis describes the …
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Mitochondrial Dynamics Alteration in Astrocytes Following Primary Blast-Induced Traumatic Brain Injury
… in bTBI; however, changes in astrocyte-specific mitochondrial dynamics have not been characterized. As a result of fission and fusion, the mitochondrial structure is constantly altering shape to respond to physiological stimuli or stress insults by adapting structure and function, which are …
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Investigating the function of PINK1 in cancer development and pathogenesis
… that dynamin related protein 1 (Drp1)‐mediated mitochondrial fission is enhanced in PINK1‐ deficient MEFs, and that increased expression of Drp1 on mitochondria and activation of Drp1 is highly significant in PINK1‐deficient multinucleated cells. Deregulated and increased levels and activation …
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Mechanisms of Regulation of Mitochondrial Dynamics by the Actin Cytoskeleton
… We investigated mechanisms of regulation of mitochondrial dynamics by the actin cytoskeleton. First, we examined actin’s influence over equivalent mitochondrial partitioning between daughter cells in mitosis. Propagating in the space surrounding mitochondria is a wave of actin polymerization …
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The Role of FAM21 in the Regulation of Mitochondrial Dynamics
Mitochondrial network remodelling is crucial for cells to adapt and respond to metabolic cues and stress signals. Processes collectively known as mitochondrial dynamics, including ongoing cycles of fusion and fission, regulate mitochondrial shape, size and distribution, governing mitochondrial …
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