Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Mitochondrial DNA Repair"”.
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Effect of mitochondrial respiratory defecton hepatocellular carcinoma :Involvement of mtOGG1 and NUPR1
Many solid tumor cells exhibit mitochondrial respiratory impairment. However, the mechanisms of such impairments in cancer development remain unclear. In this study, to investigate an effect of mitochondrial dysfunction on hepatocellular carcinoma, the two projects were studied. The first project …
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Investigation of Huntingtin’s Role in DNA Repair and Transcription
… as a member of the nuclear Transcription-Coupled DNA Repair (TCR) complex. Both wild type and mHTT were shown to interact with several nuclear DNA repair and transcription proteins, including PNKP, RNA Polymerase, DNA ligase III, CREB, and Ataxin3 (Atxn3). HTT is directly implicated in regulating …
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Essentiality of Mitochondrial Genome Integrity in Cell Survival
The mitochondrial genome encodes 22 tRNAs, 2 rRNAs, and 13 polypeptides that are subunits of the electron transport chain involved in oxidative phosphorylation. Because of its proximity to source of ROS generation and its non-chromatinized structure, mitochondrial genome is continuously challenged …