Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 103 for “"Mitochondrial DNA (mtDNA)"”.
-
Genetic variation among Zulu sheep sub-populations of South Africa assessed by microsatellites and mitochondrial DNA (mtDNA)
… used two molecular markers (microsatellites and mitochondrial DNA) to investigate the genetic diversity of Zulu sheep. In experiment 1, 26 microsatellite markers were used; (i) to confirm or disconfirm the structuration among eight Zulu sheep populations (Eshowe, Jozini, Makhathini research …
-
Pharmacogenomics and pharmacokinetics of antiretroviral drugs and their associations with metabolic complications in HIV-infected Black South Africans
… part, may be explained by host genetic factors. Mitochondrial DNA (mtDNA) variation influences ART related metabolic complications. However, the associations between genetic polymorphisms and pharmacokinetics of antiretroviral drugs, and their associations with metabolic complications, are …
-
Effects of Resistance Training on aged Skeletal Muscle and Mitochondrial Function
… production of reactive oxygen species (ROS), and mitochondrial DNA (MtDNA) deletions and mutations. Muscle mass declines at a rate of 1-2% each year after the age of 50, leading to muscle weakness, functional impairments, loss of independence, and an increase in falls. Additional declines in …
-
The Regulation of NAP4 in Saccharomyces cerevisiae
… of Hap4 protein, and (3) presence or absence of mitochondrial DNA (mtDNA).</p>
-
Systematics and biogeography of the Great Basin pocket mouse, Perognathus parvus
… structure in P. parvus were tested using mitochondrial DNA (mtDNA) sequences and Restriction Fragment Length Polymorphisms (RFLPs). High levels of sequence divergence support the hypothesis of late Tertiary isolation of Columbia Plateau from Great Basin populations of P. parvus due to late …
-
Molecular phylogeographic structure within the Perognathus fasciatus species-group
… P. fasciatus, P. flavescens, and P. apache. DNA sequence analysis of mitochondrial DNA (mtDNA) revealed that these three species comprise a monophyletic clade relative to other species of Perognathus. MtDNA sequence divergence and nucleotide diversity are much higher within populations of P. …
-
DIRECT REPEATS AND DELETIONS IN MITOCHONDRIAL DNA: CASUAL AND EVOLUTIONARY ASPECTS
… to understand the role of sequence motifs and DNA misalignments in mitochondrial DNA (mtDNA) deletion mutagenesis. Meta-analysis of age-related deletion breakpoints indicated that in human and rhesus monkey but not in mouse and rat, the average distance observed between a mtDNA breakpoint and …
-
Pharmacogenetics of stavundine : role of genetic variation in mitochondrial DNA and polymerase gamma among adult Malawian HIV/AIDS patients
… the genetic correlates for drugs associated with mitochondrial toxicity that are used as part of HIV therapy, especially nucleoside reverse transcriptase inhibitors (NRTIs). Toxicity from NRTIs manifests through metabolic diseases such as peripheral neuropathy, lipodystrophy, lactic acidosis and …
-
Transcription Regulates Biased Mitochondrial DNA Inheritance
Maintaining mitochondrial DNA (mtDNA) is essential in eukaryotes for cellular respiration and ATP production by oxidative phosphorylation. Respiration is the preferred method for creating mitochondrial membrane potential, which is important for the import of nuclearly encoded proteins into the …
-
Population substructuring in Schreibers' long-fingered bat (Miniopterus schreibersii) in South Africa
… was investigated using microsatellites and mitochondrial DNA (mtDNA), with the aim of determining the degree of genetic differentiation among colonies, and the extent and direction of bat movement among the colonies. A genomic library was constructed for M. schreibersii, and was screened for …
-
Sequence Detection and Comparative Analysis of the Hv1 and Hv2 Control Regions of Human Mitochondrial DNA by Denaturing High-Performance Liquid Chromatography
… mixtures of non-concordant amplicons of human mitochondrial DNA (mtDNA). The reproducibility and efficacy of DHPLC results, including amplification reproducibility, injection reproducibility, and column-to-column reproducibility were measured, showing negligible assay-to-assay variability. In …
-
Involvement of mitochondrial transcription factor A (TFAM) in porcine gametogenesis and preimplantation embryo development
Mitochondrial Transcription Factor A (TFAM) is responsible for maintenance and transcriptional control of mitochondrial DNA (mtDNA). TFAM knockout is embryolethal. We have studied the expression and distribution of TFAM in the gametes and preimplantation embryos of a domestic pig (Sus scrofa), a …
-
Mitochondrial DNA replication in pre-implantation embryonic development
All eukaryotic cells possess mitochondrial DNA (mtDNA), which is maternally inherited through the oocyte, its replication being regulated by nuclear-encoded replication factors. It was hypothesised that mtDNA replication is highly regulated in oocytes, pre-implantation embryos and embryonic stem …
-
A sequencing-based analyisis of epigenetic modifications of the mitochondrial genome
… important epigenetic modifications of nuclear DNA, where it regulates gene expression. Methylation of mitochondrial DNA (mtDNA) has been studied using whole genome bisulfite sequencing (WGBS), but recent evidence has uncovered major technical issues, which introduce a potential bias during …
-
Impact of mtDNA Signature on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Progression and Cardiometabolic Outcomes in Mice
… are established contributors, variation in mitochondrial DNA (mtDNA) has been linked to differences in bioenergetic function, oxidative stress, and disease susceptibility. Given mitochondria’s central role in metabolism and their unique maternal genomes, mtDNA haplotypes, shaped by …
-
Whole Blood Mitochondrial DNA Depletion in Human Immunodeficiency Virus-Infected Children
… transcriptase inhibitors (NRTIs) interfere with mitochondrial DNA polymerase gamma causing significant toxic effects, including fatal lactic acidosis. Little is known about mitochondrial DNA (mtDNA) in human immunodeficiency virus (HIV) infected children who face a lifetime exposure to these …
-
Characterization of FMP35: A novel gene and its role in mitochondrial DNA stability
… mitochondria. Many nuclear encoded proteins give mitochondrial DNA (mtDNA) the high stability needed so that life can thrive. Saccharomyces cerevisiae (baker's yeast) has historically been a model organism for mitochondrial function studies. These yeast are categorized as facultative anarobes; …
-
Analysis of mitochondrial DNA variation in the Egyptian population and its implications for forensic DNA analysis
The genetic sequence of human mitochondrial DNA (mtDNA) is of particular interest to forensic investigations involving human identification, as well as population genetics. The current mtDNA database is lacking sufficient representatives of African mitochondrial DNA sequences compared to European …
-
Consequences of Pathogenic Mitochondrial DNA Mutations in Cancer Progression
Mitochondrial DNA (mtDNA) mutations are prevalent in human cancers; however, their functional impact on cancer progression remains controversial and uncertain. This uncertainty is primarily due to a lack of suitable models for controlled functional studies. This thesis addresses this limitation by …
-
Phylogeography of the Night Lizard, Xantusia henshawi, from Southern California
… was analyzed by constructing a genealogy using mitochondrial DNA (mtDNA) sequence data. A 379 base pair region of mtDNA (cytochrome<em> b</em>) was amplified and sequenced for lizards representing 13 localities across their known range in southern California. •The resulting gene tree was …
Page 1 of 6