Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 317 for “"Mitochondrial DNA"”.
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Mitochondrial Dna Analysis By Pyrosequencing
Mitochondrial DNA (deoxyribo nucleic acid) is typically used in forensic casework when small quantities of high molecular weight quality DNA is not expected to be present thus negating the chances of obtaining usable nuclear DNA. Typical samples that utilized mitochondrial DNA analysis are: hair, …
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Transcription Regulates Biased Mitochondrial DNA Inheritance
Maintaining mitochondrial DNA (mtDNA) is essential in eukaryotes for cellular respiration and ATP production by oxidative phosphorylation. Respiration is the preferred method for creating mitochondrial membrane potential, which is important for the import of nuclearly encoded proteins into the …
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Studies on the mitochondrial DNA of Tetrahymena
The mitochondrial DNA from the ciliate protozoan Tetrahymena furgasoni str. W/ATCC. was isolated and mapped using six restriction enzymes. The linear molecule was seen to be approximately 35 Md. in size, slightly larger than the mtDNA seen in other Yetrahymena strains. The T. furgasoni mtDNA …
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Bioinformatic Approaches to Study Mitochondrial DNA Heteroplasmy
… multiple copies of their own small, circular DNA, known as mitochondrial DNA(mtDNA). Mutations in mtDNA can be maternally inherited or somatic, when they occur after fertilisation. There are mechanisms at both the extra- and intracellular levels to prevent the transmission of these mutations …
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Evolution of gender associated mitochondrial DNA in bivalves
… Unionidae and Mytilidae possess a unique mode of mitochondrial DNA inheritance dubbed sex-limited mitochondrial DNA (mtDNA) inheritance or doubly-uniparental inheritance (DUI). In contrast to the matrilineally restricted inheritance of mtDNA in other metazoans, these bivalves have both …
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Investigating neuronal mitochondrial DNA loss in Drosophila melanogaster
… and lipid metabolism. Mutations in or loss of mitochondrial DNA (mtDNA) can cause neurodegeneration and has been linked to Parkinson‟s disease. However, the pathological consequences of mtDNA loss in neurons are very poorly understood.<br/><br/>We have used the fruitfly, Drosophila …
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Mitochondrial DNA replication in pre-implantation embryonic development
All eukaryotic cells possess mitochondrial DNA (mtDNA), which is maternally inherited through the oocyte, its replication being regulated by nuclear-encoded replication factors. It was hypothesised that mtDNA replication is highly regulated in oocytes, pre-implantation embryos and embryonic stem …
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Mitochondrial DNA in ancient human populations of Europe.
… in the nonrecombining maternally inherited mitochondrial DNA has been studied in a wide array of modern populations in order to reconstruct the migrations that have participated in the spread of our ancestors on the planet. However, population genetic processes (e.g., replacement, genetic …
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Mechanisms Controlling the Segregation of Mitochondrial DNA Heteroplasmy
Mutations of the mitochondrial DNA (mtDNA) are often the cause behind primary mitochondrial disorders affecting 1:5000 individuals. However, the full extent of the impact that mtDNA mutations have is yet to be comprehensively understood. One of the main reasons behind our slow progress in the …
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Consequences of Pathogenic Mitochondrial DNA Mutations in Cancer Progression
Mitochondrial DNA (mtDNA) mutations are prevalent in human cancers; however, their functional impact on cancer progression remains controversial and uncertain. This uncertainty is primarily due to a lack of suitable models for controlled functional studies. This thesis addresses this limitation by …
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Identification and Characterization of Mitochondrial DNA Variants in Alzheimer's Disease
… population regardless of ethnicity or gender. A mitochondrial hypothesis of AD has been proposed based on a number of studies which establish altered oxidative phosphorylation (OXPHOS) and ATP synthesis in AD tissue. ATP demand is most prevalent in the brain; damage to OXPHOS could severely …
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Systematics of cetaceans using restriction site mapping of mitochondrial DNA
… using Restriction Endonuclease Maps (RSM) of mitochondrial DNA (mtDNA). One species from the suborder mysticeti (baleen whales) was sampled, and of the ten odontocetes (toothed whales) sampled two were from the family Ziphiidae (beaked whales) and eight were from the family Delphinidae …
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Evolution of asexuality in Daphnia pulex: Implications of mitochondrial-DNA analysis.
… and restriction fragment pattern analysis of mitochondrial DNA. A large amount of genetic variability was revealed by both the electrophoretic and mitochondrial data sets. A total of 104 genetically distinct clones were discovered. Comparison of the two data sets revealed that the obligate …
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DIRECT REPEATS AND DELETIONS IN MITOCHONDRIAL DNA: CASUAL AND EVOLUTIONARY ASPECTS
… to understand the role of sequence motifs and DNA misalignments in mitochondrial DNA (mtDNA) deletion mutagenesis. Meta-analysis of age-related deletion breakpoints indicated that in human and rhesus monkey but not in mouse and rat, the average distance observed between a mtDNA breakpoint and …
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Mitochondrial DNA Copy Number, Insulinemic Potential of Lifestyle, and Colorectal Cancer
… containing an independent genome, i.e., mitochondrial DNA (mtDNA). It has been increasingly recognized that mtDNA copy number (mtDNAcn) is a biomarker for mitochondrial function and cellular oxidative stress. To date, the few studies that have assessed associations between mtDNAcn and CRC …
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Later Life Consequences of Developmental Mitochondrial DNA Damage in C. elegans
… health [1]. They contain thir own genomes (mtDNA) which encode 13 proteins that are all subunits of the mitochondrial respiratory chain (MRC) and are essential for oxidative phosphorylation [2]. mtDNA is present in multiple copies per cell, usually between 103 and 104 , though this number is …
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Systematic relationships in southern African Francolins as determined from mitochondrial DNA
… history of this group is presented, using mitochondrial DNA (mtDNA) as an evolutionary tool. A comparison of mtDNA restriction fragment lengths has been used to help define the phylogenetic relationships between 13 southern African Francolin species and a selected outgroup, the Japanese …
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Characterisation of Mitochondrial Dynamics and Mitochondrial DNA Inheritance in Drosophila melanogaster
… organelles and there is mounting evidence that mitochondrial dysfunction is linked to a variety of diseases. During spermatogenesis in <i>Drosophila melanogaster</i>, the organisation of mitochondrial networks is altered during each stage of development. This thesis is focused on a novel …
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Human mitochondrial DNA and population structure of the Western Mediterranean Islands
… a comparative analysis of ancient and modern mitochondrial DNA (mtDNA). By integrating high-resolution mitogenomic data, the study aims to explore how migration, colonization processes, and long-term geographic isolation have shaped the genetic structure of insular populations over time. A …
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