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Showing 1 to 11 of 11 for “"Mitochondrial Ca2+"”.
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Investigating the role of mitochondrial Ca2+ in in vivo models of neurodegenerative diseases
… pathological hallmarks associated with NDs, mitochondrial dysfunction has emerged as a common and critical factor. Mitochondria play a central role in cellular processes, including sequestering and releasing Ca2+. The dysregulation of mitochondrial Ca2+ homeostasis has recently been …
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Celastrol induces paraptosis-like cell death via mitochondrial Ca2+ overload in breast cancer cells
… Generation of reactive oxygen species and mitochondrial Ca²⁺ overload was shown to act as a critical early signal in celastrol-induced paraptosis-like cell death contributing to the dilation of mitochondria/ER and subsequent paraptotic cell death. Inhibition of mitochondrial Ca2+ uniporter …
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Mitochondrial Calcium Uptake: LETM1 and MICU1 Are Mitochondrial Proteins That Regulate Mitochondrial Calcium Homeostasis and Cellular Bioenergetics
Mitochondrial calcium (Ca2+) uptake has been studied for over five decades, with crucial insights into its underlying mechanisms enabled by development of the chemi-osmotic hypothesis and appreciation of the considerable voltage present across the inner mitochondrial membrane (ΔΨm) generated by …
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The Effects of S-glutathionylation on the Structure and Function of the Mitochondrial Calcium Uniporter (MCU)
Most calcium (Ca2+) entry into the mitochondrial matrix is regulated by the mitochondrial calcium uniporter (MCU). The amino (N)-terminal domain (NTD) of MCU is a regulatory component of the channel. S-Glutathionylation of Cys97 on the MCU-NTD leads to robust MCU activation and increased matrix …
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Quercetin and chloroquine synergistically induces cell death in glioma cells via the increase of Ca2+ and ROS levels
… quercetin and CQ increases intracellular and mitochondrial Ca2+ levels. The cell death by quercetin plus CQ was effectively inhibited by dantrolene (a ryanodine receptor antagonist) and RU-360 (an inhibitor of mitochondrial uniporter), suggesting that the release of Ca2+ from the endoplasmic …
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Mitochondria-Endoplasmic Reticulum Contact Sites: Regulation and Roles in Coordinating Cell Fate Decisions
… for cellular processes such as lipid metabolism, mitochondrial dynamics, mitochondrial Ca2+ signalling and apoptosis. MERCs are vital in coordinating cell fate decisions and their deregulation is associated to the aetiology of several diseases including cancer, diabetes and neurodegenerative …
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Structural And Mechanistic Elucidation Of The EF-hand In LETM1 Ca2+/H+ Antiporter Function
Mitochondrial calcium (Ca2+) is integral cellular energy production; however, excessive Ca2+ leads to cell death. Both these processes are crucial to cellular function, and thus Ca2+ homeostasis is tightly regulated. Leucine zipper EF-hand containing transmembrane protein-1 (LETM1) is an essential …
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Identification and functional characterisation of different inner mitochondrial membrane supercomplexes
… is densely packed with proteins necessary for mitochondrial activity, including oxidative phosphorylation (OXPHOS) complexes and transporters. Mitochondrial respiratory chain (MRC) complexes, which generate ATP by OXPHOS, associate in higher-order assemblies, known as supercomplexes (SC), that …
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Role of Membrane Contact Sites in the Neuropathogenesis of GM1-Gangliosidosis
… in the PM of neurons, is known to modulate Ca2+ flux through its interactions with Ca2+ channels and Ca2+ binding proteins. GM1 is also known to promote neuritogenesis through the activation of phosphorylated TRKs, receptors for neurotrophic factors. Under disease conditions, GM1 accumulates …
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Molecular Determinant of Mitochondrial Shape Change
Mitochondria shape cytosolic Ca2+ (cCa2+) transients. Ca2+ entry into the mitochondria is driven by the highly negative mitochondrial membrane potential and through a highly selective channel, the Mitochondrial Calcium Uniporter (MCU). Mitochondrial Ca2+ (mCa2+) is utilized by the matrix …
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GIMAP5 influence la survie des cellules T naïves en participant à la régulation du calcium emmagasiné dans les organites
… de GIMAP5 entraîne une diminution du flux de Ca2+ ainsi qu’une réduction de la capacité mitochondriale à emmagasiner du Ca2+ suite à la stimulation du TCR. Cependant, GIMAP5 n'est pas une protéine mitochondriale. Afin de mieux comprendre le rôle de GIMAP5 dans la biologie des cellules T, au …