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Showing 1 to 8 of 8 for “"MitoQ"”.
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Evaluation of a novel mitochondria‐targeted anti-oxidant therapy for ischaemia-reperfusion injury in renal transplantation
… of the mitochondria-targeted antioxidant MitoQ in reducing pig and human kidney IR injury using an ex vivo normothermic perfusion (EVNP) system. Over a range of 500 nM to 250 µM using a 150 pig kidneys and 80 declined deceased human kidneys, MitoQ was successfully taken up by pig and human …
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Cardiorespiratory fitness as a cardiovascular protective mechanism of endothelial dysfunction with aging
… dose, 80 mg) mitochondrial-specific antioxidant (MitoQ) supplementation. In a double-blind, randomized, placebo-controlled study design 23 (10M/13 F, age 62.1 ± 2.4 y) MA/O adults (≥45 y) were separated into two groups; exercisers (EX, n=11) and non-exercisers (NEX, n=12). All participants …
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The Effects of Mitochondria-targeted Antioxidant Supplementation on the Adaptive Response to Exercise, Athletic Performance, and Recovery
… Mitochondria-targeted antioxidants such as MitoQ are designed to accumulate in mitochondria and provide targeted protection against oxidative stress. However, the effects of mitochondria-targeted antioxidant supplementation on the adaptive response to exercise in skeletal muscle, athletic …
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Role of oxidative stress in photoreceptor degeneration
… mitochondrially targeted ubiquinone derivative (MitoQ), which is a powerful antioxidant, to try and slow the rate of retinal degeneration. MitoQ was administered orally during pregnancy and for an extended postnatal period and uptake, toxicity, breeding behaviour and survival were assessed. Rates …
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Antioxidents or reduced oxygen tension as a defense system in T cells ex vivo and in vitro
… ebselen, NAcetyl L- Cysteine (NAC) or mitoQ or reduced oxygen (O2) tension on markers of T cell function and integrity using CD4+ T cell clones and ex vivo polyclonal human peripheral blood derived mononuclear cells or CD4+ T cells derived from healthy young and older aged donors. The …
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Cryopreservation of pancreatic islets
… intracellular uptake, and (2) antioxidants MitoQ and salidroside to reduce cryopreservation-induced oxidative stress. Due to the complex architecture of pancreatic islets, human mononuclear cells were first used to optimise the use of permeabilising polymers. Current methods of viability …
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Regulation of the redox homeostasis during polyglutamine misfolding in Huntington’s Disease
… (L-NAC and Trolox). Moreover, the use of MitoQ (Coenzyme Q10 covalently attached to triphenylphosphonium cation (TPP+)) at nanomolar concentrations abrogated the increased ROS due to mhttEx1 suggesting a mitochondrial origin of ROS.<br/><br/>Given that molecular chaperones regulate the …
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Antioxidants in Normal and Epileptic Brain: Effect on Synaptic Plasticity, Neural Network Physiology, and Memory
The brain undergoes continuous changes in structure and function in response to internal and external stimuli. The hippocampus, crucial in spatial learning and declarative memory, undergoes synaptic plasticity-augmented neuronal activity generating elevated amounts of reactive oxygen species (ROS) …