Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Misassembly"”.
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Dynamic Parallelism in GPU Optimized Barnes Hut Trees for Molecular Dynamics Simulations
… are very interesting, their misfolding or misassembly can lead to deleterious repercussions that lead to diseases such as Parkinson's and Alzheimer's. MD simulations have played key roles in successes so far in directing experiments that lead to therapies, but advances in high performance …
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A Quantitative Exploration of Causes of False Positive Single Nucleotide Polymorphisms in Next-Generation Sequencing Data
… false positive SNPs. These include reference misassembly due to the presence of paralogous sequences and read cross-mapping, along with associated factors such as quality of the reference sequence, read length, choice of mapper and variant caller, mapping stringency, and filtering of SNPs by …
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Characterization of AG10, a potent stabilizer of transthyretin, and its application in enhancing in vivo half-life of therapeutic peptides
<p>The misassembly of soluble proteins into toxic aggregates, including amyloid fibrils, underlies a large number of human degenerative diseases. Cardiac amyloidoses, which are most commonly caused by aggregation of Immunoglobulin (Ig) light chains or transthyretin (TTR) in the cardiac interstitium …
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A gene-space de Bruijn graph framework for improved genotyping of antimicrobial resistance genes
… regions of the genome that are prone to misassembly. This thesis focuses on the development and application of a novel de Bruijn graph–based data structure, the gene-space de Bruijn graph (gene DBG), for AMR gene detection. In this graph, the k-mer alphabet is the set of genes in the …