Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Minimum effective dose."”.
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Covariate-adjusted ROC regressions and the extensions in trend tests.
… of the ROC regression models to determining the minimum effective dose is presented in Chapter Four, where the parametric and beta regression approaches were compared through a simulation study. Chapter Five applied ROC regression in three real clinical studies: incontinence data, pancreatic …
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The effects of gene replacement therapy on respiratory and gait function in a canine model of X-linked myotubular myopathy
… treatment was carried out at three different doses to determine the minimum effective dose for full preservation of function. Respiratory function and ambulation were measured in these dogs and compared to untreated and normal true control littermates over time. XLMTM dogs treated …
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Novel Approaches to Exposure Assessment and Dose Response to Contaminants in Drinking Water and Food
… novel methods for exposure assessments and dose responses to contaminants in drinking water and foods. Factors that greatly impact contaminant exposures and human dose response include: population susceptibility (i.e., healthy adults or children), different routes of exposures (i.e., …
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Short-Chain Fatty Acids and Glucagon -Like Peptide-2 Enhance Intestinal Development and Adaptation
… glucose cotransporter, SGLT-1. However, the minimum effective dose that is necessary to enhance intestinal function is unknown. Therefore, GLP-2 was coinfused with TPN at three physiological doses: low, moderate and high. Results show that the mRNA abundance of the basolateral …
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Innovative Methods for the Design and Analysis of Phase II Clinical Trials
… key challenges in phase II trials in terms of dose-ranging study, patient population selection, and decentralized clinical trials (DCTs). This dissertation presents a comprehensive set of methodologies that address these critical issues with three projects. The first project introduces a …
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Anorexigenic effects of naltrexone in rats
… NTX from saline, except at very high doses. However, in those discrimination experiments, NTX-treated animals had not been fed palatable foods, i.e., diets whose consumption affects the endogenous opioid system thereby potentially leading to changes in sensitivity to opioid receptor …