Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"Minimal Residual Disease"”.
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Multi-Modality Plasma-Based Detection of Minimal Residual Disease in Triple-Negative Breast Cancer
… of tumor in patients who are technically “disease-free” after neoadjuvant chemotherapy and surgery as early as possible might be able to predict recurrence of patients, and then provide timely intervention for additional therapy. To this end, I applied the analysis of “liquid biopsies” for …
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Electrorotation and Dielectric Profiling: Advanced Strategies for Detecting Minimal Residual Disease in Multiple Myeloma
Il mieloma multiplo (MM) è una neoplasia ematologica incurabile caratterizzata dall'espansione clonale delle plasmacellule tumorali che producono anticorpi monoclonali non funzionali. È caratterizzato da una marcata eterogeneità genetica e clinica che complicano il trattamento e determinano …
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The significance of aberrant phenotypes and multidrug resistance for evaluation of the dynamics of minimal residual disease in acute leukemia patients /
… applying the original flow cytometric assay for minimal residual disease detection. We found that several aberrant phenotypes of patients with acute myelogenous leukemia (CD13+CD33+CD56+, CD5+, CD7+) are related to an increased multidrug resistance and through this mechanism influence a higher …
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Sergančiųjų ūmine leukemija aberantinių fenotipų ir dauginio atsparumo vaistams nustatymas ir svarba vertinant minimalios liekamosios ligos dinamiką /
… leukemia patients and assess their impact on minimal residual disease dynamics. 114 patients with newly diagnosed acute leukemia were included in the study. 35 patients had acute B-lymphoblastic leukemia, 29 - acute T-lymphoblastic leukemia, 50 - acute myelogenous leukemia. The control group …
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An in vivo RNAi therapy screen identifies novel mediators of leukemia-microenvironment interaction
Minimal residual disease refers to those cancer cells that persist following initial therapy. In precursor B-cell acute lymphoblastic leukemia (BCP-ALL), the presence of minimal residual disease is a strong prognostic indicator of relapse. The establishment of minimal residual disease fundamentally …
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BiTEs and CAR-Ts : immunotherapy in childhood B-cell acute lymphoblastic leukemia
… leukemia to nearly 90%. However, the problems of minimal residual disease and relapsed and refractory disease persist. Personalized, targeted therapies have improved outcomes among the minority of patients for whom chemotherapy is ineffective. Immunotherapy, specifically bispecific T-cell engaging …
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Immune Landscape of early liver metastatic lesions in a Novel Immunocompetent Murine Colorectal Cancer Metastasis Model
<p>Colorectal cancer minimal residual disease (MRD) represents a major clinical problem for colorectal cancer patients, with failure rates of surgery and adjuvant chemotherapy between 5% to 40% depending on stage of disease. In our study, we simulated MRD using genetically engineered organoids with …
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Effects of Pharmacological and Genetic Disruption of Chemokine Receptor Cxcr4 In B-Cell Acute Lymphoblastic Leukemia
… drugs, a mechanism that might be responsible for minimal residual disease after conventional chemotherapy against B-ALL. Indeed, in this study we observed that B-ALL cells that had migrated beneath the BMSCs were highly resistant to chemotherapeutic drugs. Inhibition of CXCR4 to disrupt this …
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Resolving the evolution of Oesophageal Adenocarcinoma using spatial and temporal sampling
… the clinical potential of ctDNA detection for minimal residual disease using two different strategies, namely cancer panel versus personalised assay. Materials and Methods Multi-region whole exome sequencing was performed on chemotherapy-naïve 398 samples from 79 patients with OAC. The samples …
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Automated Analysis of Flow Cytometry Data for B-Cell Lymphoma
… rate of a test case with all profiles, the disease type can be determined. To strengthen the system, a confidence level of diagnosis is defined to assist the physician in making a better decision. This technique is validated by comparing the diagnosis result, given by the proposed algorithm, …
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Improving the Monitoring of Multiple Myeloma Patients Using Blood Based Markers of Disease
… the M-protein. Multiple myeloma is a complex disease, and despite great advances in both detection and treatment of the disease, there remains a vast amount of interest in improving patient outcomes. In the era of novel agents and clinical trials, patients with MM are living longer and there …
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Il cane come modello animale spontaneo di patologie neoplastiche dell'uomo: ene Ataxia-Telangiectasia Mutated (ATM) Nnella predisposizione al cancro ed importanza dei riarrangimanti genici dei geni Ig/TCR per la diagnosi e prognosi delle malattie linfoproliferative
… molecular assays for diagnosing and assessing minimal residual disease in lymphoproliferative disorders of dogs, are presented. The results of those molecular assay may be directly translated in the field of Veterinary practice as well as the may be used to improve our objective evaluation of …
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Deconvolution of Leukemic Evolution Through Initiation, Progression and Relapse
… These findings emphasize the need for improved minimal residual disease monitoring (MRD) and the development of therapeutic strategies that eliminate all genetic clones equally to prevent disease recurrence. Chromosomal translocations in B-ALL are known to be early initiating events occurring …
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Untersuchungen zur Tumor-spezifischen Glykosilierung des Karzinom-assoziierten epithelialen Adhäsionsmoleküls EpCAM in Kopf-Hals-Karzinomen (SCCHN)
… Patienten mit SCCHN könnte dies insbesondere bei minimal residual disease zu einer Verbesserung der bisher ungünstigen Prognose führen.
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Development and Characterization of an Autologous Whole Cell Breast Cancer Vaccine
… the recurrence and progression of non-metastatic disease. Current adjuvant treatments, such as chemotherapy and radiation, have severe side effects and may result in overtreatment and drug resistance. </p> <p>Since greater than 90% of patients are diagnosed between stages I-III and have minimal …
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Communicating Cancer: From Concepts to Care
… biomarkers in patient care. Chapter 4 analyses minimal residual disease (MRD), an important biomarker in precision oncology intended to measure residual cancer cells after treatment. I argue that the conditions required for MRD’s success as a predictive biomarker are unlikely to hold across …
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Detection of trace levels of circulating tumour DNA in early stage non-small cell lung cancer
… DNA (ctDNA), can detect and quantify cancer in a minimally invasive way and can provide information on tumour heterogeneity. Current limitations in the liquid biopsy field are centred around the general sensitivity of the present assays and the input and logistical requirements for sensitive …
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Characterizing the Activity of Three Novel Differentiation-Inducing Compounds in Neuroblastoma Cells
… patients is treatment-resistant relapse due to minimal residual disease. Current post-remission maintenance therapy includes the use of differentiation agent 13-cis-retinoic acid. However, approximately 50% of patients treated become unresponsive to this agent. The discovery of new …
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