Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Minimal Cell"”.
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Towards The Engineering Of A Synthetic Minimal Cell
Cell-free expression (CFE) systems are one of the main platforms for building a synthetic cell. A major drawback is the orthogonality of cell-free systems across species. To generate a CFE system compatible with recently established minimal cell constructs, we attempted to optimize a Mycoplasma …
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Simulating the cell cycle of the minimal cell in 4D
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-12-01
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Extrinsic regulation of fate choice in mouse haematopoietic stem cells
… of fate choice in mouse haematopoietic stem cells The mechanisms regulating stem cell self-renewal, proliferation, and differentiation are still not fully understood. Improving our knowledge of these processes will not only provide greater insight into stem cell biology but will also have …
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Effects of oxygen on embryonic stem proliferation, energetics, and differentiation into cardiomyocytes
Most embryonic stem (ES) cell research has been performed using a gas-phase oxygen partial pressure (pO2gas) of 142 mmHg, whereas embryonic cells in early development are exposed to cellular pO2 (pO2cell) values of about 0-30 mmHg. Murine ES (mES) cells were used as a model system to study the …
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Spatial control of ligand presentation on biomaterial surfaces
Adhesion of many cell types to the extracellular matrix or to synthetic bioactive surfaces is mediated by transmembrane integrin receptors. Integrin clustering is believed to be closely associated with focal contact formation and signaling, as assessed by the behavior of cells on surfaces …
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Comparative proteomic analysis of Australian epidemic Bordetella pertussis
… is an important factor for re-emergence. Since acellular vaccine (ACV) introduction, the predominant strains changed to single nucleotide polymorphism (SNP) cluster I (ptxP3/prn2) from cluster II (ptxP1/prn3). An in vivo mixed infection in mouse showed that cluster I were fitter than cluster II …
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Informing Therapeutic Approaches For Infectious Disease And Heart Disease, Focusing On Cell-Free Synthesis Of Bacteriophages And Calcium Transport By Serca
… the functional scope and optimizations of the cell-free transcription and translation (TX-TL) platform developed in the Noireaux lab, as described by my 2016 ACS Synthetic Biology publication. This work discusses the breadth of synthetic biological applications available with a cell-free TX-TL …
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Centrifugal recovery of embryonic stem cells for regenerative medicine bioprocessing
… to realise the potential of embryonic stem (ES) cells as a regenerative medicine, it is crucial that economical, robust and scalable bioprocesses be established. Because bioprocesses irrevocably define the safety and efficacy of any biologically derived product, an understanding of the the impact …
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Analysing M. avium-macrophage interactions and establishing a long-term infection in a novel and realistic model of lung alveolar macrophages, Max Planck Institute Cells
… exclusively infiltrates the macrophage intracellularly, MAC has evolved several tools to establish its foothold in the host. MAC persists intracellularly in the host by evading host immune responses via mechanisms such as preventing phagolysosome fusion and acidification which allows it to …
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Reliable Low Latency Machine Learning for Resource Management in Wireless Networks
… Then, a novel concept of three-dimensional (3D) cellular networks, that integrate drone base stations (drone-BS) and cellular-connected drone users (drone-UEs), is introduced. For this new 3D cellular architecture, a novel framework for network planning for drone-BSs as well as latency-minimal …