Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Minichromosome"”.
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Sequence and Functional Structures of the Extrachromosomal rDNA Minichromosome of Physrum Polycephalum
… both as a satellite DNA molecule, and as a "minichromosome" with associated chromatin proteins. The genes coding for the 19 S, 26 S, and 5.8 S rRNAs are transcribed as a single, large precursor molecule, beginning nearer the center of the palindrome and transcribing outward. The genes are in …
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Resolving the Role of POU1F1 in Human Growth Hormone Locus Activation
… hGH-N expression. In the present study, a novel minichromosome model of the hGH-N regulatory domain was employed, showing that HSII confers robust POU1F1-dependent activation of hGH-N in this system. This effect was accompanied by POU1F1-dependent histone acetylation and methylation throughout …
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Aspects of in Vivo and in Vitro Transcription in Yeast
… Although YCp19 was maintained like a yeast minichromosome at approximately one plasmid per cell, several yeast genes overexpressed their RNA 3 to 5-fold above their chromosomal counterparts. The negative superhelical density ($-$d) was measured for yeast/E. coli shuttle plasmids isolated …
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KSHV encoded viral processivity factor, ORF59, regulates multiple pathways for viral replication
… to ORF59. ORF59 also associated with minichromosome maintenance proteins (MCMs), a complex of DNA replication licensing factor required for cellular DNA replication.
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Mcm10 regulates the turnover of DNA polymerase alpha.
… is crucial for prolonged health of an organism. Minichromosome maintenance (Mcm) 10 is an essential, highly conserved replication factor with multiple functions at the fork. Critical for Mcm10's role at the fork is its DNA binding activity. Utilizing the crystal structure of the conserved …
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Signal Transducer and Activator of transcription-1 (STAT-1) und STAT-1 assoziierte Proteine (MCM3,MCM5) in epithelialen Ovarialkarzinomen : Expressionsanalysen und Prognostische Relevanz
… (STAT1) und STAT1-assoziierter Moleküle („minichromosome-maintenance“: MCM-3, -5) in epithelialen Ovarialkarzinomen des Stadiums IIIc zu untersuchen und auf ihren prognostischen Wert hin zu überprüfen. <br>Dazu wurde auf RNA- und Protein-Ebene die Expression von STAT1 in normalen Ovarien …
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Characterizing Femoral Structure of the Ts66Yah Mouse Model of Down Syndrome
… Hsa21 orthologous genes on a freely segregating minichromosome, but there is speculation that the phenotypes are exaggerated by non-Hsa21 orthologous trisomic genes also present. To address this issue, the Ts66Yah mouse model was developed to remove the non-Hsa21 orthologous trisomic genes. In …
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Biological Functions of Intracellular Hepatitis B e Antigen
… we found that the nuclear p22 can bind to cccDNA minichromosome and affects cccDNA maintenance and/or transcription. Thus, our results indicate that there is a novel ER sorting mechanism for the distribution of the intracellular and secretory HBeAg, and the intracellular HBeAg may contribute to …
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Functional characterisation of cohesin subunit SMC3 and separase and their roles in the segregation of large and minichromosomes in Trypanosoma brucei
… two main classes of chromosomes, large and small minichromosomes, need to be faithfully replicated and segregated during the cell cycle. Although the large and minichromosomes are colocalised and segregated by association with the mitotic spindle, minichromosomes exhibit segregation patterns that …
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Molecular Characterization of Mth203 protein
… Cdc6 and ORC proteins. It also contains a single minichromosome maintenance protein (MthMCM) homologue which forms a hexameric complex and acts as a DNA helicase. What loads the archaeal MCM helicase and how DNA replication initiation is regulated is still unknown. Mth203, a putative RNA helicase …
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Molecular characterization of Mth203 protein
… Cdc6 and ORC proteins. It also contains a single minichromosome maintenance protein (MthMCM) homologue which forms a hexameric complex and acts as a DNA helicase. What loads the archaeal MCM helicase and how DNA replication initiation is regulated is still unknown. Mth203, a putative RNA helicase …
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Immunohistochemical and molecular studies on ovarian cancer progression and prognosis
… in EOC were identified, i.e. Chek1, Chek2 and minichromosome maintenance complex component 3 (MCM3). Paper III provides a first description of expression of the Dachshund 2 (DACH2) protein in any form of human cancer, after its identification in the Human Protein Atlas portal. DACH2 expression …
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Safeguard of Mitosis: The Spindle Checkpoint
… the kinetochore null 1 complex (Knl1C), the minichromosome instability 12 complex (Mis12C), and the nuclear division cycle 80 complex (Ndc80C). In my first project, I have shown that the non-kinase domain of Mps1 directly binds to Ndc80C through two independent interactions. Both interactions …
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Molecular-cytogenetic analysis of repetitive sequences in genomes of Beta species and hybrids
… classes of repeats were used to characterize the minichromosomes of the sugar beet fragment addition lines PRO1 and PAT2 by comparative multi-color FISH. The study allowed to propose a schematic pattern of repetitive DNA organization on the PRO1 and PAT2 minichromosomes. PRO1 has an acrocentric …