Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Mineralocorticoid receptor"”.
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Mineralocorticoid receptor involvement in vascular dysfunction associated with vascular injury
Mineralocorticoid receptor (MR) signaling has recently been implicated in cardiovascular dysfunction associated vascular injury. Specifically, MR blockade has been shown to treat coronary microvascular dysfunction in obesity and has been implicated in the regulation of capillary density in ischemic …
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Analysis of the role of the mineralocorticoid receptor in renal principal cell sodium reabsorption in vivo
Germline inactivation of the mineralocorticoid receptor (MR) gene in mice results in early postnatal lethality due to massive loss of sodium and water associated with impaired epithelial sodium channel (ENaC) activity in kidney and colon. The aim of the present study was the analysis of the role of …
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Corticosteroid hormone action in the cardiovascular system
… an important target of corticosteroid hormones. Mineralocorticoid receptor antagonists provide cardiovascular protection and are now routinely used in disorders such as primary hyperaldosteronism, resistant hypertension and congestive heart failure (CHF) but the underlying molecular mechanisms of …
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Characterization of Rapid Nongenomic Cortisol Signalling in Rainbow Trout Liver
… by activation of the corticosteroid receptors, glucocorticoid receptor (GR) and mineralocorticoid receptor (MR), whereas the nongenomic cortisol response involves rapid changes to downstream second-messenger signalling cascades independent of gene regulation. However, nongenomic …
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Comparing Healthcare Resource Utilization and Costs in HFPEF patients using SGLT2-inhibitor Combination Treatments: A Retrospective Claims Analysis
… therapy, with the addition of either mineralocorticoid receptor antagonists (MRAs) or angiotensin receptor-neprilysin inhibitors (ARNIs) as adjunctive therapy. However, real-world evidence comparing healthcare resource utilization (HCRU) and costs between these combination therapies …
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Exploring the bidirectional interface between stress and innate immunity: a focus on glucocorticoid and TLR4-MyD88 signalling
… that the priming effect on IL-1β was mediated by mineralocorticoid receptor (MR) signalling, while immunosuppressive actions were mediated by glucocorticoid receptor (GR) signalling. Study 3 further assessed glucocorticoid actions on non-cytokine innate immune responses via measurements of cell …
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Rapid Non-genomic Actions of Cortisol in Fish
… by activating the intracellular glucocorticoid receptor (GR) and/or the mineralocorticoid receptor (MR), or through non-genomic pathways. However, the mechanism of action of non-genomic cortisol signalling is far from clear, and there is a complete lack of consensus as to the physiological …
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Stress hormones epinephrine and corticosterone modulate herpes simplex virus 1 and 2 productive infection and reactivation primarily in sympathetic, not sensory, neurons
… ganglia (SCG) neurons expressed adrenergic receptors and glucocorticoid receptor. In productively infected neuronal cultures, epinephrine treatment significantly increased HSV-1 DNA replication and production of viral progeny in SCG neurons, but no significant differences were found in TG …
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Pathophysiological role of aldosterone in cardiac remodelling after myocardial infarction
… genetic and neurohormonal factors, including the mineralocorticoid hormone aldosterone, are implicated in its pathogenesis. Aldosterone antagonism reduces cardiovascular morbidity and mortality in patients with advanced chronic HF and survivors of large AMI who develop HF and/or are diabetic. …
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Differential regulation of herpes simplex virus-1 and herpes simplex virus-2 during latency and post reactivation in response to stress hormones and nerve trauma in primary adult sensory and sympathetic neurons
… utilized the combination of α and β adrenergic receptor complex, while CORT signaled through glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) to reactivate HSV in the neurons. NTFs are tissue-target derived growth factors required for neuronal protection and survival. …
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Investigation of different blood pressure regulating systems in kininogen-deficient BNK rats
… most physiological effects mediated by the B2 receptor in both rat strains. We found that the deleterious effects of salt diet in BNK rats are in fact attributable to enhanced mineralocorticoid action. The renal mineralocorticoid receptor (MR) displayed an overexpression and several mutations …
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Role of 11β-hydroxysteroid dehydrogenase type 2 in protection against inflammation during atherogenesis: studies in the Apoe-/- /11β-HSD2-/- double knockout mouse.
… and progression of cardiovascular disease. Mineralocorticoid receptor (MR) over-activation has been implicated in atherosclerosis. In mineralocorticoid-target tissues, 11β- Hydroxysteroid dehydrogenase type 2 (11β-HSD2) inactivates glucocorticoids, conferring aldosterone specificity upon the …
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Renal Epithelial Sodium Channel (ENaC) Regulation of Pregnancy Mediated Hemodynamic Adaptations: Mechanistic Insights
… was abolished by pretreatment with the mineralocorticoid receptor antagonist, eplerenone. These findings demonstrate that the increased α ENaC subunit of pregnancy is associated with a mineralocorticoid-dependent increase in ENaC activity. The plasma volume increased progressively during …