Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Mindbomb1"”.
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A Genetic Screen for Tribbles Suppressors Identifies the E3 Ubiquitin Ligase Neuralized as a Novel Target
… ligases as novel interactors; Neuralized, Mindbomb1 and Parkin. Of the targets identified from the screen, we focused on Neuralized. We found that Tribbles physically bound to Neuralized in a yeast two hybrid assay and in vivo, Tribbles co misexpression in an ovarian model epithelium, the …
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Novel Role of ErbB-2 in Inhibition of Jagged-1-Mediated Trans-Activation of Notch in Breast Cancer
<p>The ErbB-2 gene is amplified and the resulting protein product overexpressed in 15-30% of breast tumors, and associated with aggressive behavior and poor overall survival. Currently, there are two FDA approved therapies targeting ErbB-2 for the treatment of ErbB-2 positive breast cancer: …