Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Miltefosine"”.
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Evaluation of Dose-Exposure-Response Relationships of Miltefosine and Discovery of Multicomponent Crystal Forms of Artesunate
Background: Miltefosine is the first and only oral medication to be successfully utilised as an antileishmanial agent. However, the drug is associated with differences in exposure patterns and cure rates among different population groups e.g. ethnicity and age (i.e., children v adults) in clinical …
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Studies using luciferase-expressing Leishmania donovani parasites
… i.e. sodium stibogluconate, amphotericin B, miltefosine and paromomycin. Intraperitoneal or bone marrow derived macrophages infected with L. donovani were incubated with different concentrations of each drug (sodium stibogluconate, 4-0.02mg/ml; amphotericin B, 4-0.02μg/ml: miltefosine, …
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Examining the effect of anti-tumor lipid drugs on pH homeostasis and membrane structure in Saccharomyces cerevisiae
… that the second-generation anti-tumor lipids, miltefosine and perifosine, cause PM disorganization in a manner analogous to edelfosine, suggesting a similar mode of action for this drug family.
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Investigation towards the role of LmxOSM3.1 phosphorylation and the identification of its interaction partners using an improved method of proximity labelling
… include pentavalent antimonials, amphotericin B, miltefosine, paromomycin, and pentamidine. Unfortunately, they do not come without limitations, hence, more effective treatments are needed. Kinases and kinesins have been shown to be promising drug targets.;LmxOSM3.1 is expected to be a plus …
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Developing novel therapeutic agents for Acanthamoeba infection and investigating the process of encystment
… included, octenidine hydrochloride, alexidine, miltefosine and quaternary ammonium (didecyldimethylammonium chloride). The anti-amoebic effect of benzalkonium chloride, povidone iodine and tetracaine are superior to the current diamidines and slightly lower to the biguanides applied in the …
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An in-vitro study investigating current and novel antimicrobial agents as potential topical treatments for cutaneous infections caused by bacteria, fungi and Leishmania
… activity against C. albicans (p < 0.001). Miltefosine is a current treatment for cutaneous Leishmaniasis, but many cationic compounds tested exhibited significantly better activity (p < 0.05) against L. mexicana amastigotes. Notably, alexidine and benzylhexadecyltrimethyl ammonium …