Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Midbrain organoids"”.
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MODELLING GBA1-RELATED PARKINSON¿S DISEASE PATHOLOGY IN PATIENT-DERIVED MIDBRAIN ORGANOIDS
… of the disease. Here, we present an innovative midbrain organoid culture system derived from subjects with GBA1-related Parkinson’s disease and Gaucher’s disease as the first patient-based model able to reproduce fundamental human neuropathological features of these disorders. We provide …
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Derivation of next generation research models of Parkinson’s disease
… neurons in the substantia nigra region of the midbrain and the presence of intracellular inclusions, notably Lewy bodies composed of the alpha-synuclein protein (encoded by the SNCA gene), in the surviving neurons. The precise molecular and cellular mechanisms governing PD's onset, progression, …