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Showing 1 to 20 of 31 for “"Midazolam"”.
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A comparison of the efficacy and safety of intranasal sufentanil/midazolam and ketamine/midazolam for sedation and analgesia in a paediatric population undergoing multiple dental extractions
… the efficacy and safety of intranasal sufentanil/midazolam [S/M] and ketamine/madazolam [K/M] for sedation and analgesia in preschool children that require dental surgery [extractions]. Fifty children [ASA 1] aged 5 – 7 years, requiring six or more dental extractions under general anaesthesia, …
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Wirkung des Benzodiazepins Midazolam auf die Dünndarmperistaltik des Meerschweinchens in vitro
… der Untersuchung: Benzodiazepine, wie z. B. das Midazolam, werden sehr oft zur Sedierung von Patienten auf Intensivstationen genutzt. Die Hemmung der gastrointestinalen Motilität ist eine beachtliche Nebenwirkung anderer Medikamente (z.B. Opioide), die der Analgosedierung dienen. Bisher ist über …
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Pediatric procedural sedation outcomes using midazolam and hydroxyzine with and without meperidine
… was to assess the effects of oral sedation using midazolam and hydroxyzine with and without meperidine on sedation outcomes in pediatric dental patients. The relationship between child temperament and sedation outcomes was also assessed. Methods: This pilot study recruited 14 children between the …
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Untersuchung der Patientenzufriedenheit und der Qualität einer Propofol/Midazolam-Sedierung bei endoskopischen Eingriffen in der Gastroenterologie
… die Patientenzufriedenheit mit einer Propofol/Midazolam-Sedierung bei verschiedenen gastroenterologischen Eingriffen als auch die Sicherheit dieser Sedierung an einem stationären Patientengut (n=269) ermittelt. Des Weiteren wurden die Veränderungen der Laborwerte AST, ALT, γ-GT und Kreatinin …
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Incidence of hypoxaemia with intravenous fentanyl and midazolam sedation in adult patients undergoing oral surgery procedures
… intravenous sedation with fentanyl and midazolam. The secondary aims included determination of the onset time of hypoxaemic events and significant risk factors for hypoxaemia. Methods: This prospective observational study required 92 patients to achieve a power of 80% at the 5% …
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Intraoperative Wachheit, postoperative Erinnerung und Erholung nachgynäkologischen, tageschirurgischen Kurzeingriffen unter Narkose mit Propofol, Etomidate, Ketamin, Methohexital und Midazolam
… (n=50), Ketamin (n=10), Methohexital (n=50), Midazolam (n=49) und Propofol (n=51) untersucht. Um mögliche intraoperative Wachepisoden der Patientinnen erfassen zu können, wurden die Patientinnen entgegen dem klinischen Alltag während der Narkose aufgefordert, die Augen zu öffnen oder die Hand …
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Sedation in paediatric intensive care
… the pharmacokinetics and pharmacodynamics of midazolam in critically ill children. 52 children, aged between 0 and 18 years were recruited to the study and 303 blood samples taken to analyse midazolam and its metabolites, I-hydroxyrnidazolam (I-OR) and 4-hydroxymidazolam (4-0H). Analysis of …
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The safety and efficacy of the propofol/ Alfentanil/ Ketamine-bolus technique in midazolam pre-medicated patients undergoing office based plastic or reconstructive surgery
The purpose of this research project was to assess the safety and efficacy of a combination of drugs for conscious sedation in patients undergoing office-based plastic and reconstructive surgery. A pilot study was done to determine the safety of the co-administration of the drugs used in the …
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Development of mouse models of hydrogen sulfide-induced neurotoxicity for the evaluation of neuroprotective strategies
… H2S. Additionally, our studies show promise for Midazolam as an antidote for treatment of H2S-induced neurotoxicity as it reduced H2S-induced mortality by 90% when given prior H2S exposure, and reduced mortality induced by H2S by 50% when given during the exposure. Midazolam administered …
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Sedierung mit Propofol und Remifentanil zu diagnostischen und interventionellen Herzkatheteruntersuchungen im Kindesalter
… an Propofol nach intravenöser Prämedikation mit Midazolam, zur diagnostischen oder therapeutischen Herzkatheteruntersuchung im Kindesalter untersucht. Es handelt sich dabei um eine Anwendungsbeobachtung. Es zeigte sich, dass die Analgosedierung mit Remifentanil und Propofol eine sichere und …
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Fatores preditivos de dessaturação de oxigênio em pacientes submetidos à colangiopancreatografia endoscópica retrógrada sob sedação consciente
… em pacientes submetidos à CPER sedados com midazolam associado à meperidina. No total, 186 pacientes foram monitorados continuamente com oxímetro de pulso. A regressão de Cox adaptada por Braslow foi utilizada para identificar fatores preditivos de dessaturação relacionados ao paciente e ao …
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Diferencias en la sedación de pacientes pediátricos con dos formas de preparar Fentany
… Una estrategia utilizada es la combinación de midazolam más fentanyl, sin embargo no se encuentra en la literatura estudios sobre la repercusión de la forma de preparación sobre los grados de sedación, objetivo principal de este estudio. Materiales y métodos: Se realizó un estudio analítico …
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Paediatric analgesia and sedation in the emergency department
… and also using the same device for intranasal midazolam in children with persistent seizure activity. Apart from my own involvement and research into these effective methods of treatment, I have done a formal review study on the use of intramuscular ketamine for procedural sedation, and the …
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Content and Activity of Cytochrome P450 3A in Rat Brain Microsomes and Mitochondria
… of CYP3A-mediated hydroxylated metabolites of midazolam by UPLC-MS/MS. We also aim to analyze the protein levels of CYP3A in the rat brain mitochondria and microsomes by Western blot analysis.</p> <p>Microsome and mitochondria were prepared using different centrifugation methods, followed by …
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A Multicentre Implementation of a Quality Improvement Initiative to Reduce Delirium in Adult Intensive Care Units: An Interrupted Time Series Analysis
… days per ICU, percentage of sedation days using midazolam, adverse events and ICU length of stay and mortality. All outcomes were examined using mixed effects segmented linear regression with ICU site as the random effect. After the intervention, the overall percent of delirium days per ICU was …
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Multidrug sedation for dental procedures in children younger than eight
… for children. In this study project drugs like midazolam, propofol, alfentanyl and ketamine were titrated intravenously to achieve conscious sedation.
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Rapid review of drug management for paediatric seizure termination in the emergency setting
… commonly used BDZs are Lorazepam, Diazepam and Midazolam. Lorazepam is often perceived as the superior choice but recent studies have challenged this but results appear inconclusive and contradictory. This study aims to consolidate the available literature and formulate recommendations for the …
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Two-Part Reactive Formulations for Intranasal Delivery of Benzodiazepines
… behaviors for diazepam prodrug/enzyme reactions, midazolam prodrug/enzyme reactions, and midazolam acid/base reactions demonstrated that these two-part formulations generate predictable levels of supersaturated drug. An in vivo pharmacokinetic study in rats showed that rapid absorption and high …
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Pharmacokinetic and Pharmacodynamic Modelling to Advance Perioperative Anaesthesia and Analgesia
… for: propofol (an intravenous anaesthetic); midazolam (a sedative), alfentanil, fentanyl, remifentanil (phenyl-piperidine opioids); desflurane, isoflurane and sevoflurane (inhalation anaesthetics). This is the first study to describe propofol-midazolam BIS effects, which were additive. I …
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Study of efficacy of ketamine analgesia for surgical management of incomplete miscarriages
… the analgesic efficacy of ketamine with Fentanyl/Midazolam in women requiring uterine evacuation for incomplete miscarriage as measured by the patients’ perceived pain. Study design: An efficacy trial with a naturally occurring control group who received what is currently standard practice. The …
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