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Showing 1 to 4 of 4 for “"Micu1"”.
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Mitochondrial Calcium Uptake: LETM1 and MICU1 Are Mitochondrial Proteins That Regulate Mitochondrial Calcium Homeostasis and Cellular Bioenergetics
… we asked how Mitochondrial Calcium Uptake 1 (MICU1) regulates MCU activity by quantifying basal mitochondrial Ca2+ and MCU uptake rates in MICU1 ablated cells. The following work characterizes the molecules that regulate mitochondrial Ca2+ uptake and their mechanistic function on decoding …
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Molecular Determinant of Mitochondrial Shape Change
… triggered an increase in the expression of MICU1, a regulator of the mitochondrial calcium uniporter (MCU) but not the MCU core subunit. Consistently, either RNAi-mediated deletion of MPC isoforms or dominant negative human mutant MPC1 R97W showed significant induction of MICU1 protein …
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Genetic characterisation of the Drosophila Mitochondrial Calcium Uniporter in physiological and neurodegenerative contexts
… and is required for in vivo calcium uptake; and MICU1-3, which regulate the flow of ions. Animal models have emerged for some uniporter genes, but variable effects have left their physiological role uncertain. The genetic tractability of the Drosophila melanogaster model system makes it well …
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Identification and functional characterisation of different inner mitochondrial membrane supercomplexes
… reduction in CIV activity in the absence of MICU1, the main regulator of the uniporter, but surprisingly no effects were observed after MCU downregulation or pharmacological inhibition of mitochondrial Ca2+ entry. Instead, the lack of CIV seems to have an impact on MCU-containing complexes …