Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"Microvessels"”.
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Lattice Boltzmann method for integrating the Bloch equation in muscle fibers and microvessels
… with properties characteristic of the cerebral microvessels, thereby providing an innovative technique to extract intrinsic microvascular parameters in the normal aging brain.
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Effect of Calcium Phosphate Ceramic Architectural Features on the Self-Assembly of Microvessels In Vitro
… of microns, can be used to direct the growth of microvessels into the core of scaffolds. A pipeline was developed for the production of hydroxyapatite surfaces with controlled architecture. Three batches of hydroxyapatite were used with two different particle morphologies and size distributions. …
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The Study of Nitric Oxide Synthase Expression, Function, and Regulation in the Renal Vasculature During Postnatal Renal Development
… receptors in immature preglomerular resistance microvessels utilizing novel microdissection techniques; and (4) determine AII regulation of NOS expression and function in the immature renal vasculature using AT1 and AT2 receptor inhibitors.</p> <p>Isoform specific inhibition demonstrated nNOS is …
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Microviscometric Analysis of Microvascular Hemodynamics in Vivo
… rheological properties of blood flow in intact microvessels in vivo. A new microviscometric approach is presented, which we have validated through glass-tube studies in vitro (30--80 mum in diameter) and through isovolemic hemodilution studies in vivo, that provides estimates of hemorheological …
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Signaling Induced by Inflammatory Mediators in the Rodent Pulmonary Microvasculature
… reactive oxygen species generation) both in microvessels directly treated with thrombin and those far outside the instilled region (up to 1000 μm away), and the expansion of signaling into the untreated microvessels was due to intercellular communication mediated by Cx43. For the F-actin …
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A microvessel-on-a-chip for studying how tumor-derived factors prime the endothelium for extravasation
… to fabricate the model and form endothelial microvessels inside it. ☐ The second objective was developing tools to quantify key metrics of endothelial phenotype and function from the model. This consisted of developing a toolbox of image processing pipelines and corresponding ImageJ macros …
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The Influence of Dietary Fat on The Cerebral Microvasculature: Compositional, Prostaglandin Synthetic, and Permeability Studies
… prostacyclin synthesis by cortical slices and microvessels, respectively, kinetic parameters of adenosine uptake, and the potential involvement of eicosanoids in the uptake process.
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Modelling the Endothelial Glycocalyx Layer
… of a mathematical model for blood flow in microvessels coated with an endothelial glycocalyx layer (EGL). Special attention is focused on the effect of the wall layer on the system as a whole and the interaction between blood, EGL and the wall vessel. Interest in this problem is motivated …
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Altered Hemodynamic Control in the Skeletal Muscle Microcirculation in the Metabolic Syndrome: The Emergence of a new Attractor
… with adrenergic dysfunction dominating in larger microvessels and oxidant stress-based increases in thromboxane A2 dominating in smaller microvessels. Additionally, metabolic syndrome blunts the temporal compensation that would serve to attenuate the increased perfusion distribution. Combined, the …
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Image Processing Algorithms for Diagnostic Analysis of Microcirculation
… Information pertaining to the density of these microvessels within a field of view can be used to quantitatively monitor and assess the changes occurring in tissue oxygenation and perfusion over time. Automated analysis of this information can be used for real-time diagnostic and therapeutic …
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The effects of bradykinin and angiotensin II on the thoracic aorta vasa sasorum microcirculation system
Vasa vasorum forms a network of microvessels within and around the walls of large blood vessels and is thought to be necessary to deliver oxygenated blood to the outer parts of the vessel wall that are inadequately nourished by diffusion from luminal blood. Vasa vasorum flow, therefore, may play an …
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A Tissue-Engineered Microvascular System to Evaluate Vascular Progenitor Cells for Angiogenic Therapies
… sensitive peptide (6 mM). Robust hCB-EPC microvessels formed within the gel with invasion up to 150 µm depths and parameters of total tubule length (12 mm/mm2), branch points (127/mm2), and average tubule thickness (27 µm). 3D hCB-EPC microvessels showed quiescence of hCB-EPCs (<1% …
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Targeting Organic Anion Transporting Polypeptide 1A4 (Oatp1a4) for Effective Drug Delivery at the Blood-Brain Barrier
… Oatp1a4 protein expression in rat brain microvessels in vivo. Additionally, we demonstrate that BMP-9 treatment increases blood-to-brain transport and brain exposure of established Oatp transport substrates (i.e., taurocholate, atorvastatin, pravastatin). Of particular significance, we …
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Host-Defense Function of Anuclear Polymorphonuclear Neutrophil in Lung Injury
… (PMNcyto). We found that 50% of PMN in lung microvessels had transitioned to PMN cytoplasts (PMNcyto) within 24h exposure to endotoxemia. Despite being anuclear, PMNcyto displayed characteristics distinct from PMN. They showed rapid velocity compared to PMN and the ability to migrate across …
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The impact of obesity and fitness on endothelial function in polycystic ovarian syndrome
… function in conduit arteries and cutaneous microvessels, has not been explored. The primary aim of this thesis was to examine nitric oxide (NO)-mediated endothelial function at different levels of the vascular tree in women with PCOS and to establish whether supervised exercise training …
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Pericyte deficiencies in a foxf2 loss of function mutant
… to stroke that progressively weakens brain microvessels. Foxf2, a pericyte-expressed gene, is involved in vascular stability and reduced FOXF2 is associated with increased stroke risk and CSVD prevalence. Here, I use a zebrafish foxf2a loss of function mutant as a genetic model of CSVD to …
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Remodeling of the pulmonary circulation - a novel response to allergic airway inflammation
… response. Both the systemic tracheal microvessels as well as all parts of the pulmonary circulation undergo changes. The structural alterations of vascular remodeling induced by allergic airway inflammation, was similar to features as seen in airway remodeling. Vascular remodeling …
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Μελέτη της κλινικής σημασίας της αγγειογένεσης σε ασθενείς με νόσο hodgkin
… evaluate various morphometric characteristics of microvessels, highlighted by means of anti-CD34 immunohistochemistry, in the lymph node of 286 patients with HL at diagnosis and investigate their relationship with several clinicopathologic parameters and prognosis. EXPERIMENTAL DESIGN: …
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Quantifying the Relationship of Bilateral Blood Flow in Glabrous Skin at Rest and During Sympathetic Perturbations
… between sympathetic nerves and peripheral microvessels. With sympathetic activity difficult and invasive to measure directly, the possibility of using blood conductance as an indirect measure seems promising. We investigated the relationship of bilateral blood conductance recordings of both …
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