Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Microvascular Complications"”.
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Genetic contribution to type 1 diabetes microvascular complications
… risk of morbidity and mortality due to long-term complications, specifically retinopathy, nephropathy, and neuropathy. Studies demonstrating familial aggregation support the claim that a genetic contribution may influence the development of complications. This dissertation aims to identify …
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Genetic analysis of the microvascular complications of diabetes mellitus
… factors are involved in the pathogenesis of microvascular complications in diabetes mellitus. Recent studies have suggested that genetic variations in the aldose reductase (ALR2) gene may contribute to the genetic susceptibility to microvascular complications. Aldose reductase is the first …
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Relationships between subtle ocular changes and microvascular complications in people with type 2 diabetes
Background: Developing treatments for early microvascular type 2 diabetes (T2DM) complications (retinopathy (DR), peripheral neuropathy (DPN), nephropathy (DN)) is limited by insufficient understanding of early pathologies. The eye, prone to diabetic damage, is a microvascular bed accessible for …
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An Investigation for Genetic Susceptibility to Type 1 Diabetes Mellitus and its Microvascular Complications
… are implicated in the pathogenesis of diabetic microvascular diseases. Genetic mutation through the genes coding for enzymes involved in glucose metabolism and immuno-regulatory mechanisms may contribute to the susceptibility to type I diabetes mellitus (TIDM) and its chronic microvascular …
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Preventing type 2 diabetes microvascular complications: Exploring the interplay of racial/ethnic disparities and primary therapeutic interventions
… issue capable of producing a variety of adverse complications. The prevalence of T2DM microvascular complications, such as kidney, nerve, and eye problems, is higher in the U.S. than macrovascular complications such as heart disease. Racial/ethnic disparities in the prevalence of T2DM …
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Impacts of Empagliflozin (EMPA) Treatment on Skeletal Muscle Microvasculature in Type 1 Diabetic Rats
… of the disease, hyperglycemia is associated with microvascular complications, including reduced capillary ratio in skeletal muscle (SM). We investigated whether a blood glucose lowering drug, empagliflozin (EMPA), has any impact on the microvasculature in SM. T1D was induced in eight-week-old male …
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Public health burden of diabetes in Ireland: time trends, determinants of complications and the implementation of a public health intervention to improve health outcomes for people with diabetes
… of diagnosed type 2 diabetes and its related complications in adults aged 50 years and over. Trends of visual impairment and blindness due to diabetic retinopathy in adults aged 18–69 years over a decade were explored using data from the National Council for the Blind of Ireland, (2004–2013). …
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The Role of Advanced Glycation End Products (AGEs) through the TRPA-1/NRF-2 Activation Pathway in the Neurodegenerative Diseases
… various age-related diseases including diabetic complications and neurodegenerative diseases. Aging and long-term hyperglycemia causes enhanced production of this highly reactive α-dicarbonyl, which reacts with macromolecules causing irreversible damage of DNA and protein promoting the formation …
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Συσχέτιση επιπέδων λιποπρωτείνης (α) με τις μικροαγγειακές επιπλοκές του σακχαρώδη διαβήτη τύπου 2
… “hypolipidemic therapy diabetic microvascular complications”, “diabetic nephropathy”, “diabetic retinopathy” και “diabetic neuropathy”. Η αρχική αναζήτηση ανέδειξε 4.856 άρθρα. Μετά την αφαίρεση των διπλοτύπων και την αξιολόγηση τίτλων και περιλήψεων, 286 μελέτες κρίθηκαν δυνητικά …
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The molecular mechanisms of diabetes mediated impaired wound healing and the development of therapeutic strategies.
… blood glucose are associated with the vascular complications of diabetes. Microvascular complications lead to delayed wound healing in patients suffering from diabetes. Hypoxia and hyperglycaemia characterise a wound environment of a person with diabetes. Angiogenesis is central to restore the …
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The effectiveness of GLP-1 analogues compared to DPP-4 inhibitors for beta cell function and diabetes related complications among adults with type 2 diabetes: a systematic review and meta-analysis
… deterioration of plasma glucose control and complications characteristic of type 2 diabetes. Two classes of incretin-based antihyperglycaemic agents, dipeptidyl peptidase-4 (DPP-4) inhibitors and glucagon-like peptide-1(GLP-1) analogues, have shown favourable effects on beta cell function. …
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An investigation into the molecular mechanisms of hyperbaric oxygen using a human dermal microvascular endothelial cell line and a porcine retinal explant model.
… metabolic condition with associated vascular complications that are a major cause of morbidity and mortality. Endothelial dysfunction is central to microvascular complications such as diabetic retinopathy (DR) and impaired wound healing in diabetes. Hyperbaric oxygen therapy (HBOT) is the …
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A novel nutritional approach to the management of type 2 diabetes: effects of nutritional preloads on postprandial blood glucose and gastric emptying in type 2 diabetes mellitus
… control (HbA1c >8.5%), and a high prevalence of microvascular complications, indicate that 30-50% have abnormally delayed emptying of solids and/or nutrient liquids, whether studied by scintigraphy or stable isotope breath test, while a few have rapid emptying. Conversely, patients with ‘early’ …