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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 328 for “"Microtubules"”.
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The Role of Microtubules in Secretion
Microtubules have been implicated in the movement of secretory granules to the cell membrane in a variety of both exocrine and endocrine cells. A range of roles, from provision of the motive force to preventing presecretory movement, have been attributed to these organelles. An in vitro model …
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Prosthecobacter BtubAB form bacterial mini microtubules
… αβ-tubulins polymerise into giant and hollow microtubules in the presence of GTP. Despite the size of around 25 nm wide, microtubules display sophisticated dynamics. In particular, dynamic instability, the stochastic change between fast growth and rapid shrinkage, is a hallmark of …
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Topological analysis of microtubules during cell division
… morphological changes during cell division. Microtubules are biopolymers essential for functions in the cell. Understanding the role of microtubules in cell division requires characterizing their conformations during this process. In this thesis, we model the microtubules by mathematical …
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Ncd Motor Tail Domain Interactions With Microtubules
… Ncd interacts with both "highway" and "cargo" microtubules (MTs) in meiotic and mitotic spindles through the action of ATP-dependent and ATP-independent MT binding sites in the head and tail domains, respectively. Through the action of these binding sites, Ncd bundles and, perhaps, slides MTs …
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Regulation of Microtubules by Patronin within Drosophila Dendrites
… the cytoskeleton, a major component of which are microtubules, which are required for intracellular transport, as well as establishing neuronal morphology. In this thesis, I identify microtubule regulators that are necessary for the dendritic development of Drosophila sensory dendritic …
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Mechanics and Kinetics of Microtubules in Their Environment
Microtubules (MTs) are important linear protein filaments which participate in many intracellular physiological processes and provide mechanical support against external compression. The kinetics and mechanics of MTs change rather distinctively in different environment. It is therefore important to …
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Investigating Microtubules Inside Cells with Cryo-Electron Tomography
Microtubules are tubular filaments that form part of the eukaryotic cytoskeleton. They are important for cell division, shape and motor-driven transport. Axons and dendrites of neurons are filled with longitudinal arrays of microtubules. They serve as tracks for long-range cargo transport driven by …
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Structural studies of dynein’s interaction with microtubules and herpesvirus
… cytoplasmic and axonemal dynein MTBDs bound to microtubules by cryo-EM. From this, I present a new model of how dynein interacts with the microtubule, and a novel role of axonemal dyneins in physically distorting the microtubule. In my chapter 4, I use cryo- electron microscopy to demonstrate …
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Kinetochore-derived Microtubules: from Molecular Regulation to their Role in Mitosis
… cell division, spindle-pole microtubules (MTs) must capture kinetochores (KTs) so that the chromosomes can be loaded on the mitotic spindle. However, it remains a mystery how spindle-pole MTs can locate KTs with high efficiency, within realistic capture times (Wollman et al. …
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Microtubules, Acetylation, and MEC-3 Regulated Genes in C. Elegans Mechanosensations
… TRNs as well as neurons from higher organisms. Microtubules (MTs) play crucial roles in the majority of eukaryotic cells where they are required for cell division, intracellular transport, morphological stability and a variety of other functions. The TRNs of C. elegans are characterized by …
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An analysis of the role of microtubules during tubulogenesis in Drosophila
… a model to understand these changes. The role of microtubules (MTs) during morphogenetic processes such as this are not well understood. In order to ascertain their role in successful tubulogenesis I looked at both stable and newly polymerized MTs within the salivary gland placode. Apical …
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Patterning planar surfaces with motor proteins: Towards spatial control over motile microtubules
… proteins on unstructured surfaces. Specifically, microtubules themselves were used as biological templates for the stamping and alignment of motor proteins. Compared to other soft lithography techniques like microcontact printing this approach circumvented protein denaturation due to drying and …
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Physical Concepts of Copolymerization of Microtubules in the Presence of Anti-mitotic Agents
… approach to the concepts of copolymerization of microtubules in the presence of anti-mitotic drugs is presented in this work. A general feature of the mathematical equations is presented. The possibility of having analytical steady state solutions of dynamic equations is investigated. The …
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Regulated Recruitment of the Chromosomal Passenger Complex to Chromatin and Microtubules Promotes Accurate Cell Division
… drug taxol. While the SAH domain binds microtubules and is required for targeting the CPC to the spindle-midzone during anaphase, its role in the SAC during early mitosis remains unknown. Here we uncover the molecular mechanism that couples H3T3ph to the cell cycle and elaborate how the …
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On the Interactions of Augmin with Microtubules and the Mechanics of the Cross-Linker PRC1
… the bipolar spindle, self-organized from microtubules and their associated proteins. A multitude of components have been identified to be involved in this organization, and solving the combinatorial of the conditions that lead to the specific set of configurations present in vivo remains …
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Detection and Quantitation of Drug-Induced Inhibition of Rapid Axoplasmic Transport: Microtubules and Axoplasmic Transport
Made available in DSpace on 2014-12-10T23:24:35Z (GMT). No. of bitstreams: 1 7511540.pdf: 7292314 bytes, checksum: f18883ad45c26dcb784cf172343dc65f (MD5) Previous issue date: 1974
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Migration of Nucleocapsids in Vesicular Stomatitis Virus-Infected Cells is Dependent on Microtubules and Actin Filaments
… work presented here, we show a necessity of both microtubules and actin filaments on nucleocapsid migration during infection and virus assembly.
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Origin and development of floral buds in tobacco explants: organization of microtubules and microfibrils in differentiating cells
Contains fulltext : mmubn000001_078176832.pdf (Publisher’s version ) (Open Access)
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