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Showing 1 to 20 of 25 for “"Microtubule-Associated Proteins"”.
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Characterization of chartins, cytoplasmic microtubule associated proteins
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1987.
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Functional Investigation of Trypanosoma brucei Microtubule Associated Proteins and Their Role in Cellular Morphogenesis.
… generated by an elaborate array of subpellicular microtubules. This corset of microtubules requires extensive remodelling during cell growth and division. Microtubule nucleation/outgrowth and coordinated severing/re-establishment of inter-microtubule cross-links is orchestrated by microtubule …
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Biochemical and immunocytochemical analysis of three novel microtubule-associated proteins in Drosophila melanogaster and the rat brain
Microtubules are essential organelles found in almost all eukaryotic cells. Some of their diverse functions include intracellular transport, cell division and maintenance of cell shape. Microtubules are composed of highly conserved proteins, the $\alpha$- and $\beta$-tubulins. Many of the functions …
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Regulation of mitotic spindle biogenesis in budding yeast
… in yeast), separation of sister centrosomes and microtubule dynamics. Activation of Cdc28 (Cdk1) by tyrosine-19 dephosphorylation is essential for centrosome separation, the first step in bipolar spindle formation. In this study, we have investigated the regulatory role of Cdk1 in centrosome …
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Insight into Microtubule Catastrophe and Growth
Pages ii-xi are misnumbered as pages i-x.
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Molecular analysis of kinetochore-microtubule attachment in budding yeast
Kinetochores bind to microtubules and are responsible for chromosome segregation and the accurate transmission of genetic information during cell division. Kinetochores are DNA-protein complexes that assemble on centromeric DNA sequences. In budding yeast, the kinetochores consist of approximately …
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Characterization of the thermostable nature of the alpha and beta tubulin proteins in Cyanidium caldarium and Cyanidioschyzon merolae
Microtubules are critically important cytoskeletal elements. Together with microtubule associated proteins (MAPs), they form the latticework on which eukaryotic life exists. Simply put, microtubules are polymers of tubulin heterodimers, which are composed of the globular proteins alpha and beta …
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Ncd Motor Tail Domain Interactions With Microtubules
… Ncd interacts with both "highway" and "cargo" microtubules (MTs) in meiotic and mitotic spindles through the action of ATP-dependent and ATP-independent MT binding sites in the head and tail domains, respectively. Through the action of these binding sites, Ncd bundles and, perhaps, slides MTs …
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A NOVEL, RAS-INDEPENDENT ROLE FOR NF1 IN MICROTUBULE DYNAMICS AND DAMAGE REPAIR DICTATES SENSITIVITY TO T-DM1 IN HER2 POSITIVE BREAST CANCER.
… co-purify with tubulin and to co-localize with microtubules (MTs); two regions in NF1 have been proposed to mediate this interaction. The physiological relevance of this interaction remains uncertain, and NF1 is not generally included among bona fide Microtubule-Associated Proteins (MAPs). Our …
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Investigating the role of downy mildew effectors in host resistance and susceptibility
… such as rusts and mildews can deliver “effector” proteins directly into plant cells in order to manipulate specific defence responses and processes. Hyaloperonospora arabidopsidis (Hpa) is a haustorium-producing biotrophic oomycete pathogen that causes downy mildew on Arabidopsis. Over 100 …
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Actin dynamics in silico, in waves, and in rods
… In addition, cofilin-actin rod interactions with microtubule associated proteins, and associated changes to the microtubule cytoskeleton were studied for its potential relevance to the pathology of AD. Our results suggest that disruptions to the normal organization of actin and microtubules might …
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The Role of Tau in Epidermal Stratification and Differentiation and its Implications in Skin Cancer
Background: Microtubule associated proteins are a group of proteins well characterised for their role in the stabilisation and polymerisation of microtubules, but they have been increasingly demonstrated to have a more diverse role within cells. Tau is a microtubule associated protein, well studied …
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Investigation of the physiological function of TTBK2 (tau tubulin kinase 2), a protein kinase mutated in spinocerebellar ataxia type 11 (SCA11)
… based on its physical association with microtubules and its ability to phosphorylate microtubule-associated proteins (tau, tubulin, MAP2) in vitro (Takahashi et al., 1995, Tomizawa et al., 2001). Since this discovery by Japanese scientists in 1995, considerable work has been invested in …
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Role of phosphatases in the end-on conversion process
Proper attachment of chromosomes to microtubules is important for the accurate segregation of chromosomes and genome stability. The initial engagement of chromosomes happens along the lateral wall of microtubules through a highly specialised protein structure assembled on the centromeric DNA, the …
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Poxvirus A51R Proteins Directly Bind to Microtubules to Antagonize Microtubule Dynamics, Intracellular Transport, and a Cell-intrinsic Antiviral Response
Viruses often manipulate the microtubule (MT) network to facilitate their replication inside host cells. Poxvirus A51R proteins have been shown to colocalize with, and bundle, MTs, but the mechanisms of their MT interactions remained unclear. Additionally, vaccinia virus (VV), a model poxvirus, …
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Protein Composition and Subcellular Localization of the De Novo Lipogenic Metabolon
Pages 11-34 are incorrectly numbered as pages 9-32, and pages 35-124 are incorrectly numbered as pages 34-123.
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Bioinformatics Analysis and Annotation of Microtubule Binding and Associated Proteins (MAPs) - Creating a Database of MAPs
Microtubules have many roles in the cytoskeletal infrastructure. This infrastructure underlies vital processes of cellular life such as motility, division, morphology, and intracellular organization and transport. These different roles are carried out by the creation of different microtubule (MT) …
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Recombinant αβ-Tubulin and a Simple Computational Model Shed Light on the Molecular Mechanisms of Microtubule Dynamics
Microtubules (MTs) are essential to all eukaryotic organisms. They help segregate chromosomes and organize the cytoplasm. MTs are hollow barrels of the protein αβ-tubulin that exhibit a non-equilibrium behavior called dynamic instability: the stochastic switching of single polymers from a state of …
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Examining Mechanisms Regulating Microtubule Assembly and Function
<p>Microtubules are cytoskeletal polymers assembled from α and β tubulin subunits that function in essentially all cellular activities. Microtubules can act as "tracks" for intracellular cargo transport, are required for cilia- and flagella-based motility, and establish cell morphology in …
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Functional analyses of microtubule and centrosome-associated proteins in Dictyostelium discoideum
Understanding the role of microtubule-associated proteins is the key to understand the complex mechanisms regulating microtubule dynamics. This study employs the model system Dictyostelium discoideum to elucidate the role of the microtubule-associated protein TACC (Transforming acidic coiled-coil) …
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