Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Microtubule Motors"”.
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Microtubule Motors Drive Nuclear Dynamics and Positioning in Developing Skeletal Muscle Cells
… nuclear movement in myotubes requires microtubules, but the mechanisms involved have not been elucidated. Here, we find that nuclei actively translocate through myotubes. As they translocate, they also rotate in three-dimensions. These movements require an intact microtubule …
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The interconnected roles of spastin and protrudin in endosomal sorting
… Tug-of-war between kinesin and dynein microtubule motors has been shown to be essential for endosomal tubule fission and I propose that protrudin functions in this process by promoting endosome interactions with kinesin-1, which generates anterograde pulling force on the endosome to …
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Regulation of Bidirectional Microtubule-Dependent Organelle Transport in Xenopus Laevis Melanophores
… to shed light on the mechanisms that regulate microtubule-based melanosome transport by identifying receptor proteins for microtubule motors as well as signaling cascades that regulate microtubule-based melanosome movement. Biochemical assays and in vivo analysis of melanosome transport were …
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Regulation Of The Tubulin Code In Cardiac Hypertrophy And Failure
A proliferated and post-translationally modified microtubule network underlies cellular growth in cardiac hypertrophy and contributes to contractile dysfunction in heart failure. Yet how the heart achieves this modified network is poorly understood. Determining how the “tubulin code” – the …
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Analysis of the function of Drop out, the single homologue of human MAST kinases, in <i>Drosophila</i> cellularisation
… membrane recruitment via both Dynein and Kinesin microtubule motors. Furthermore, the localisation of the Dynein subunit Dynein light intermediate chain (Dlic) displays only minor changes in <i>dop</i> mutants and is not altered expressing phospho-mutant versions of the candidate Dop substrate …
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Engineered Cytoskeletal Arrays Reveal Mechanisms Of Membrane Transport And Tubulation
Within the cell, cytoskeletal molecular motors transport and remodel membrane-bound cargos along microtubule and actin filament tracks. Typically, there are multiple actin and microtubule motors attached to the same cargo, which must coordinate to navigate a complex cytoskeletal environment and …
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Studies of Huntington's disease associated motor domain phosphorylation of kinesin-1
In neurons, microtubule motor driven transport is crucial for communication between processes and the cell body. Disruptions in transport are associated with a variety of neurodegenerative diseases. Recent studies implicate phosphorylation of serine 175, a conserved residue found in all three …
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Genetic analysis of dynein function in the nervous system and in mitosis
Cytoplasmic dynein-1 is an essential microtubule-based molecular motor. Aided by several adaptors and co-factors, dynein orchestrates retrograde transport of diverse cargoes in interphase cells and plays multiple roles in mitosis. The importance of this motor is underlined by the fact that …