Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Microtubule Assembly"”.
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Examining Mechanisms Regulating Microtubule Assembly and Function
<p>Microtubules are cytoskeletal polymers assembled from α and β tubulin subunits that function in essentially all cellular activities. Microtubules can act as "tracks" for intracellular cargo transport, are required for cilia- and flagella-based motility, and establish cell morphology in …
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Heterodimer formation and tublin function in S. cerevisiae
Many effectors of microtubule assembly in vitro enhance the polymerization of subunits. However, several S. cerevisiae genes that affect cellular microtubule dependent processes appear to act at other steps in assembly, and to affect polymerization only indirectly. Here we use a mutant …
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Modulating protein-protein interactions : novel inhibitors of PDZ domains and tubulin dynamics
… Compound 35 wasfound to be a potent inhibitor of microtubule assembly, whilst compounds 45 and 47were found to promote and stabilise the formation of microtubules. This observation isthe first described for this pharmacophore. Compound 45's activity was identified asbeing independent of binding to …
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Experimental and Computational Studies in Bioorganic and Synthetic Organic Chemistry
… is coupled with flexible PEG linker. However, microtubule assembly assay suggested that these new dimers are not capable of effecting bivalent binding to the Taxol binding sites in microtubules. Memory of chirality (MOC) is an emerging theme in asymmetric synthesis in which the dynamic …
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Understanding molecular and cellular processes using statistical physics
… dynamics at both cellular and molecular levels. Microtubule dynamics and dynamic disorder of enzyme proteins are two of the examples we investigated. The dynamics of microtubules and the mechanical properties of these polymers are essential for many key cellular processes. However, critical …
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The Substrate and Regulator of Acetyltransferase San
… substrate. Tubulins are the building blocks of microtubules, which display dynamic instability. By regulating the rate of microtubule assembly and disassembly, cells organize the microtubule cytoskeleton to accommodate their specific functions. Posttranslational modifications of tubulin have …
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Two-Photon Microscopy of E-Combretastatin uptake and activation in live mammalian cells
… act by binding to p-tubulin, preventing microtubule assembly andinhibiting angiogenesis in developing tumours. Most widely studied is the natural productc/5(Z)-combretastatin A4 that was originally isolated from the African bush willowCombretum caffrum by Pettit and co-workers. Chemically …
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Investigating the effects of tau mutations in induced pluripotent stem cell-derived neurons
Microtubule-associated protein tau (MAPT) is a neuronal protein which promotes microtubule assembly and stabilisation. The MAPT gene is alternatively spliced to give six tau isoforms: three with 3 microtubule-binding repeats (3R, excluding exon 10) and three with 4 microtubule-binding repeats (4R, …
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Dynamics and equilibria of weak protein interactions in cells
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-08-01