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Showing 1 to 3 of 3 for “"Microsomal cytochrome p450"”.
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Effects of Pycnogenol on Microsomal Cytochrome P450 Activity and Apoptosis
… <p>Metabolic activation of NNK depends upon cytochrome P450 enzymes (GYP). A second study looked at O-dealkylation of the substrates benzyloxyresorufin (BROD), ethoxyresorufin (EROD) and methoxyresorufin (MROD) linked to CYP2B1,2C6 and 1A2, respectively. Pycnogenol significantly inhibited …
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Covalent Binding and other Mechanisms of Primaquine Toxicity
… covalent binding of primaquine to mouse liver microsomal protein was found in both in vitro and in vivo studies. The binding in vitro was linear during the first 90 minutes of incubation and dependent on the concentration of mouse liver microsomal protein. The in vitro covalent binding was …
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Characterisation of mammalian cytochrome P450 enzymes by their metabolic activities.
… investigate and thereby characterise human liver microsomal cytochromes P450 responsible for the in vitro transformation of the B-carbolines, harmine and harman. Comparative studies were also carried out with rat liver microsomal P450s, where the effects of induction on the metabolism of harmine …