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Showing 1 to 13 of 13 for “"Microphysiological Systems"”.
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Sensing in 3D Printed Neural Microphysiological Systems
… goal of producing sensor functionalized neural microphysiological systems to enable deeper fundamental understandings of disease pathology and to provide drug screening and discovery platforms for improved clinical translation. Towards this goal, work addressing three broad objectives has been …
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Innovative microphysiological systems for long-term real-time imaging in biomedicine
… patients with better therapies is represented by microphysiological systems (MPSs), also noted as Organ on Chip (OoC) devices. This recent strategy tackles the primal issue mentioned above, which is at the very basis of our capabilities i) to understand patho-physiological processes and ii) screen …
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Advanced Bioelectronic and Microphysiological Systems for Functional Studies of Stem Cell-Derived Neural Models
… electronics, and human-relevant in vitro systems. The research spans: • 2D compartmentalised cultures for studying tauopathy in Alzheimer’s disease using microphysiological and bioelectronic systems; • Air-liquid interface cerebral organoids (ALI-COs), interfaced with Neuroweb, a porous, …
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Characterizing Failure Modes in Continuous Flow Microfluidic Pumps
Microphysiological systems provide novel platforms for drug testing and therapeutic target discovery, through their three-dimensional morphologies that mimic specific tissues and organs. In concurrence with these systems, microfluidic channels allow for a sufficient supply of nutrients to the cell …
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Engineering micro-perfusable scaffolds for MesoPhysiological Systems using projection Micro-StereoLithography
MicroPhysiological Systems (MPS) are in vitro models that capture the complexity of human organs at miniature scale by recreating the native microenvironment of resident cells. These systems offer promising alternatives to in vivo animal models for the development of new drugs, disease modeling and …
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Integrated Microfluidic Culture Media Oxygenator for Organ-on-a-Chip Applications
Microphysiological systems (MPS) are in vitro platforms for the culture of human cells in a manner that closely mimics the in vivo physiological microenvironment. Oxygen is a key element for maintaining cell viability and function in MPS devices. Thus, this thesis presents the design, fabrication, …
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Microfluidic Platform for Vascularized Tissue Models
… to support 3D vascularized tissue models for microphysiological systems. The platform delivers pneumatic pressure and vacuum signals to drive fluid flow and pressure on tissue culture devices with integrated pumps and back-pressure regulators. The mechanical performance of the pumps and …
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A low volume oxygenator for open well Liver-on-a-Chip tissue culture
MicroPhysiological Systems (MPS) show significant promise in speeding drug development and advancing basic research. They may serve better than animal models for obtaining accurate human response data and thereby reducing failed clinical trials. The CN Bio LiverChip is one such commercial MPS …
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Smooth Flow Control for On-Chip Pneumatic Micropumps
… can achieve smooth flow, fluidic conditions of microphysiological systems can be controlled to accurately mimic biological conditions. Biological experiments can require flow profiles anywhere on the spectrum of smooth flow to highly pulsatile flow. A smooth flow profile can be modified with …
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Electromagnetic pump and hardware development for organs-on-chips
MicroPhysiological Systems (MPS), also called organs-on-chips, attempt to mimic the relevant human multi-organ physiology in-vitro. They have potential applications in drug development and personalized medicine by enabling more accurate testing of physiological drug response earlier in the …
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IMPLEMENTATION OF 3D CELLULAR MODELS FOR DRUG AND TOXIN TESTING IN HEALTHY AND CANCEROUS TISSUE
… of pharmaceutical drugs, it is imperative that microphysiological systems represent their parent tissue as accurately as possible. It is essential that any preclinical model is human, able to recapitulate the organization, cell type, and proper cell to cell interactions. Human 2D cell line …
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Development of novel in vitro platforms to model the lung
… AT2 cells. One of the limitations of in vitro systems is the inability to culture primary cells, including AT2 cells, for a long time without loss in their phenotype and identity. Until recently, a feeder layer of supporting stromal cells was required to culture AT2 cells in vitro. While medium …