Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Micronucleus formation"”.
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Genetic interactions of repriming and translesion synthesis
… and greater genetic instability as assessed by micronucleus formation. The roles of REV1 and PRIMPOL were also probed in the context of replication of non-B-DNA secondary structures. REV1 appeared to be of greater importance in the replication of G-quadruplex structures than PRIMPOL when …
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ASSESSING THE GENOTOXICITY OF TRICLOSAN IN TADPOLES OF THE AMERICAN BULLFROG, LITHOBATES CATESBEIANUS.
… for its simplicity and economy, is the micronucleus assay. A study was conducted assessing the genotoxicity of the widely used antimicrobial agent Triclosan to American Bullfrog tadpoles. Lithobates catesbeianus tadpoles were reared in glass aquaria containing ultra-high purity water and …
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Appraisal and validation of rapid, integrated chemical and biological assays of environmental quality
… hydrocarbons and faecal sterols. Useful information is provided and problems with e.g. HCHs and sewage contamination are highlighted. Contamination by DDTs, PCBs, "total" hydrocarbons and PAHs is also reported. Next, these techniques are used to develop rapid screening methods. Four …
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Genoprotective effect of aspirin and ibuprofen in human lymphocyte cells. Effect of nano and bulk forms of aspirin and ibuprofen on lymphocytes from breast cancer patients compared with those from healthy females
… healthy females as a control using the Comet and micronucleus assays. Western blot analysis (WBA) was used to investigate the effect of these drugs on XRCC3 and p53 proteins, whereas QPCR was to evaluate this effect on p53, cox1 and cox2 genes. Two hundred fifty ng/ml of ibuprofen (NP and bulk) …
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THE ROLE OF RETROTRANSPOSITION AND EXOSOMAL DNA IN RADIATION-INDUCED GENOMIC INSTABILITY
… delayed mutations, chromosomal aberrations, and micronucleus formation in the descendants of irradiated cells many generations after the initial radiation insult. At present the mechanism of RIGI remains elusive, however it is possible that the random insertion nature of the LINE-1 …
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Genoprotective effect of aspirin and ibuprofen in human lymphocyte cells. Effect of nano and bulk forms of aspirin and ibuprofen on lymphocytes from breast cancer patients compared with those from healthy females
… healthy females as a control using the Comet and micronucleus assays. Western blot analysis (WBA) was used to investigate the effect of these drugs on XRCC3 and p53 proteins, whereas QPCR was to evaluate this effect on p53, cox1 and cox2 genes. Two hundred fifty ng/ml of ibuprofen (NP and bulk) …
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RADIATION-INDUCED CHROMOSOME INSTABILITY AND INTERCELLULAR COMMUNICATION: THE ROLE OF DOSE RATE AND IMPLICATIONS FOR CARCINOGENESIS
… induce delayed mutations, chromosomal damage and micronucleus formation in the progeny of cells many generations after the original radiation event. The work presented explores the role of dose and dose rate, as well as radiation quality, on RIGI. For low-LET x-rays, the induction of RIGI in …
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Exploring the role of endogenous DNA damage in neurodegeneration
… to understand the genetic determinants of micronucleus formation – another DNA damage-linked phenomenon associated with neurological phenotypes – I began validating and exploring some of the mechanistic underpinnings of *DSCC1*-induced genomic instability caused by defective sister …
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Design, Off-Target Toxicity, and Intracellular Processing of Nucleotide-Modified Messenger RNAs for Human Therapies
… and 5-methylcytidine exhibited increased micronucleus formation, suggesting that these nucleosides may be genotoxic at high doses. 5-methoxyuridine was detected in purified nascent cellular RNA from exposed cells, suggesting that 5-methoxyuridine is a substrate for cellular nucleotide …