Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"Microneedles"”.
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Engineered microneedles for transcutaneous vaccine delivery
… from sugar-glass coatings on bioresorbable microneedles. Formulation in microneedle coatings improved vaccine stability at room temperature and preclinical testing of these vaccine patches in mice and nonhuman primates demonstrated equivalent immunogenicity compared to parenteral injection, …
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Tissue electrical impedance determination via microneedles
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2002.
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Microneedles for Drug Delivery in Aquaculture
… proposes an alternative by using biocompatible microneedles that can be applied in situ and dissolve to release the drug. The focus of this project is the needle fabrication method and coating selection to provide necessary mechanical strength to withstand aquatic environments. It was found that …
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Fiberoptic Microneedles for Transdermal Light Delivery
… tissue. To develop this solution, fiber optic microneedles capable of delivering light for therapy were manufactured. We have manufactured fiberoptic microneedles by tapering silica-based optical fibers employing a melt-drawing process. These fiberoptic microneedles were 35 to 139 microns in …
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Micro-injection moulded microneedles for drug delivery.
… parameters and will help in achieving sharp microneedles with acceptable quality. Hence high shear rheology of these selected materials was performed at wall shear rates carried out in excess of 107 s-1 over a range of temperatures to predict the flow behaviour of polymer melts at such high …
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Polymer substrates with microneedles for epidermis injection
… macroneedles. A spectic substrate system with microneedles can prevent irflammation or tear of the epidermis but still puncture for cargo release. Depending on the substrate contact surface area, a larger microneedle array can be utilized, for a higher success rate of release beyond individual …
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Layer-by-layer coated microneedles for cancer immunotherapy
Over the past few decades, research in therapeutic cancer vaccines has achieved remarkable advances in both pre-clinical and clinical studies. However, strategies to boost antigen presentation and T cell priming in order to increase the fraction of patients responding to immunotherapy remains an …
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Study of mechanical effects of microfluidic channels in microneedles
Modern neural probes integrate microfluidic chemical sampling to measure spatio-temporal neurochemical transients in the brain while also pursuing miniaturization to minimize tissue damage. This brings into question the effect of the integrated microfluidic channels on the mechanical integrity of …
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Epicutaneous Delivery of Allergens Using Dual Stimuli-Responsive Liposomes-Loaded Dissolving Microneedles
… liposomes incorporated into dissolving microneedles (dMN) were developed. The compatibility of food allergens with stigmasterol (STG)-based liposomes, their release kinetics in response to various stimuli, and the suitability of liposomes in microneedle formulations were studied. Peanut …
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Development of dissolving and hydrogel-forming microneedles for delivery of vancomycin hydrochloride
Methicillin-resistant Staphylococcus aureus (MRSA) can cause harmful and potentially deadly infections, including neonatal sepsis. Vancomycin, a glycopeptide antibiotic, remains the most effective antibiotic to treat this condition. In the case of systemic diseases, vancomycin must be administered …
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Design and Fabrication of Out-of-Plane Silicon Microneedles with Integrated Hydrophobic Microchannels
… procedures developed to produce pyramidal-shaped microneedles with microchannels that will allow for fluid delivery. The microchannels are etched into the substrate surface of a [100] silicon wafer using inductively coupled plasma etching. After the channel etch a layer of silicon nitride is …
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An alternative diagnostic method using microneedles for sampling the immune system in situ
… hydrogel-coated, immune-monitoring, sampling microneedles that are capable of sampling non-recirculating immune cell populations present in the skin and permitting the quantification of biomarkers present in collected dermal interstitial fluid, thus enabling the parallel monitoring of both …
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DEVELOPMENT OF MICRONEEDLES ON FLEXIBLE SKIN PATCH WITH FUNCTIONAL COMPONENTS FOR TRANSDERMAL DRUG DELIVERY APPLICATIONS
This work aims developing different kinds of microneedles with various configurations and functions for transdermal drug delivery applications. Here we developed a very unique technology called drawing lithography for the assembly of SU-8 and maltose sharp tips at the final step of the fabrication …
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Microneedle delivery for improved efficacy of antiretroviral and antibiotic drugs
… could benefit greatly from delivery through microneedles. Microneedles (MN) offer an increase in efficacy for these drugs by providing delivery to the lymphatic system through the skin, thus avoiding first pass metabolism and allowing more focused delivery to specific viral or bacterial …
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Delivery of large molecules via microneedles and self-gelating biodegradable hydrogels for the treatment of degenerative bone conditions
Osteoarthritis is a debilitating condition affecting millions globally; it is an ever-expanding problem, due in no small part to an aging population and the growing obesity crisis. As humans grow older, joint degeneration is inevitable, and as people live longer these problems will commensurately …
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Dissolvable microneedle manufacturing methods and the application of three-dimensional printing to pharmaceuticals
Dissolvable microneedles are an intradermal drug delivery technology with exciting potential for widespread distribution of minimally invasive, self-administered medicines and vaccines. The most popular manufacturing method for medical dissolvable microneedles is micromoulding, a process which can …
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Precision Delivery of Multi-Scale Payloads to Tissue-Specific Targets in Plants
… by tuning the material composition. Silk-based microneedles further show minimal wounding responses, activation of gibberellic acid (GA₃) responses post-injection of GA₃-loaded microneedles, and promotion of bolting and inhibition flower formation by GA₃ on Arabidopsis thaliana mutant ft-10. …
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Targeted drug delivery within the eye
… choroid, and posterior segment of the eye using microneedles as a drug delivery platform. The first part of the work determines the ability to deliver protein therapeutics into the cornea using coated microneedles to suppress corneal neovascularization in a rabbit model. The data show that highly …
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Controlled release microneedle technologies for the enhanced immunogenicity of subunit vaccines
… in this thesis towards this end. Membrane microneedles consist of tips with a polymeric core that contains vaccine that's encapsulated within a crosslinked layer-by-layer film. The three component film acts as a tunable diffusional barrier to vaccine release. Poly([gamma]-propargyl …
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Design of novel drug delivery system and optimal dosage regimens
… application of an electric current and soluble microneedles were proposed for the first time. Preliminary experimental studies suggested that the electric field enhanced the flux by increasing drug diffusion and, thereby, the dissolution of the microneedles. One-, two- and three-dimensional …
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