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Showing 1 to 15 of 15 for “"Micromixer"”.
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Computational and experimental determination of the mixing efficiency of a microfluidic serpentine micromixer
In microfluidics, efficiency and mixing time are the greatest disadvantages. These parameters hinder the application of microfluidic devices for biochemical and immunological assays. However, once these disadvantages have been overcome by optimizing the parameters of the microfluidic device, it …
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A numerical study on microbubble mixer
… numerical study of the mixing performance on the micromixer, a device which actuates steady streaming by semi-cylindrical sessile bubble oscillations. The mixer's capability of producing chaotic mixing is confirmed and a numerical simulation that is in good agreement with the experiment is …
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Development of a PDMS Based Micro Total Analysis System for Rapid Biomolecule Detection
… micro total analysis system include a micropump, micromixer, magnetic separator and interdigitated electrodes for impedance detection. Three designs of pneumatically actuated PDMS based micropumps were fabricated and tested. Based on the performance test results, one of the micropumps was selected …
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Development of a micromixing system for treatment of ORL 48 microtissues in different concentrations of cytochalasin B
… In this study, a polydimethylsiloxane (PDMS) micromixer was designed, simulated and prototyped using vinyl tape method and successfully applied to mix and dilute Cytochalasin-B in culture media (CB-DMEM, 30.0 μM) with 0.05 % ethanol solutions (diluent) to produce four different concentrations …
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Transport-Kinetic Processes and Surface Chemistry in Biosensor Design
… kinetics are diffusion-limited. A serpentine micromixer, originally designed to mix two fluids in bulk solution via ""chaotic advection,"" is used to mix the sample as it passes through a surface plasmon resonance biosensor. These experiments indicate that such ""solution-based"" mixing …
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Optimizing mixer geometries for dielectrophoretic micro-concentrators
… In particular, the optimal geometries of micromixers for the device are investigated and determined by simulations and experiments. The optimal micromixer-enhanced concentrator exhibits up to 1.5 x improvement in trapping efficiency as compared to a concentrator without mixers.
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3D integration of micro- and nanostructures into bio-analytical devices
… undyed water injected from separate inlets of micromixer were mixed along the microchannel at flow rates of 10 and 40 μL/min. The standard deviation of the normalized intensity measured in the confocal image of the cross section of the channel was used for quantifying the degree of mixing and …
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Computational fluid dynamic (CFD) optimization of microfluidic mixing in a MEMS steam generator
… on the geometric optimization of a static micromixer channel by considering the trade-off between mixing quality and pressure drop. Both zigzag and straight channels are evaluated, in addition to channels with differing amounts of added obstruction features. Due to computational limits, the …
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Towards automatic gene synthesis with bioinformatics software, novel one-step real-time PCR assembly, and lab-chip gene synthesis
… hydrogel valves, electromagnetic micromixer, shuttle micromixer, volume meters, and magnetic beads based solid-phase PCR purification module, fabricated using a fast prototyping method without lithography process. The fabricated device is combined with a miniaturized thermal cycler …
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Improving the stability of an oxime based electrochemical microsensor for organo-phosphate vapor detection
… time, and thus decreased liquid flowrate. Micromixer performance was studies at a 10:1 aqueous buffer to organic solution flow rate ratio, for a total rate of 5.5 μL/min. It was found that the sensor response utilizing the integrated micromixer was nearly identical to the response when the …
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Physics and Applications of a PDMS Based Centrifugal Microfluidic System
… was less than 0.5%. In the last part, a micromixer was developed based on the similar principle. The results show that the flyball governor system can effectively agitate the chaotic mixing of the sample liquids by periodically deflecting the PDMS membrane of the mixing chamber. The …
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Freeform, direct-write assembly of thermoplastics and glasses: Theory, practice, and applications
… is applied to create a highly efficient helical micromixer in a material that is refractive-index-matched to water, enabling complete imaging with multiphoton microscopy. Freeform assembly also is shown to be a viable method for making polymeric medical devices, including polylactide stents and …
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Pharmaceutical crystallization design using micromixers, multiphase flow, and controlled dynamic operations
… controlled. Various configurations of micromixers were designed to provide controlled nucleation. Based on the dual-impinging-jet (DIJ) configuration, a physical explanation was provided for the discovery that a cooling micromixer can generate small crystals of uniform size and shape. …
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Passive micromixers for DNA analysis using CFD modelling
… is an important issue in the design of micromixers, since effective mixing is required between Deoxyribonucleic acid (DNA) sample and restriction enzyme for a fast digestion process. Mixing is improved by chaotic advection through serpentine mixing channels. This leads to the desired …
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Polymeric nanocapsules for pharmaceutical applications
Polymeric nanoparticles can be used for drug release in cancer therapy. Nanoparticles can be divided into nanospheres and nanocapsules, accordingly to their structure. Nanospheres are constituted by just the polymer, while nanocapsules have an inner liquid core surrounded by a polymer layer. Drug …