Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"Micromanipulation"”.
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Optical tweezers for signal detection and micromanipulation
The work presented in this thesis explores new multi-disciplinary applications of optical tweezers in the physical and biological sciences. Firstly, the three dimensional trapping of partially silvered sphere in a standard TEM00 optical trap was characterised. These spheres were then coated with an …
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Probing Mitotic Chromosome Structure and Arrangement Using Micromanipulation
… brought into contact with one another during micromanipulation. Cognizance of this possibility allows such artifacts to be avoided. Centromeres are connected to the spindle, which appears as a fibrous network at the center of the radial array with phase contrast and scanning electron …
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Coherent micromanipulation of 1-D BEC in designed potentials
The manipulation of quantum degenerate gases has seen a flourishing of results in the last years. One of the most used tools to create and address a Bose-Einstein condensate (BEC) is the atomchip: A lithographycally patterned surface on which gold conductors are used to generate magnetic fields. To …
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Mechanically-induced intercellular remodeling of cardiomyocytes by magnetic micromanipulation
… gels and mechanical stimulation using magnetic micromanipulation. Cardiomyocytes were patterned on polyacrylamide gel using 25pm and 50pm microchannels. Mechanical stimulation was induced in sections with high densities of magnetic beads.
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Automation of Single Cell Micromanipulation and Microsurgery for Blastocyst Embryo Biopsy
… in single cell biology demonstrates that micromanipulation and microsurgical advance strategies are required to carry out single cell surgical processes, such as the Preimplantation Genetic Diagnosis (PGD). To perform PGD, a sample from the inner material of the embryo is extracted using a …
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DNA profiling of single sperm cells and single skin flakes in forensics using micromanipulation and whole genome amplification.
… in the pre-amplification step of template DNA. Micromanipulation was used to isolate single spermatozoa. Furthermore, micromanipulation in combination with REPLI-g Single Cell WGA resulted in successful DNA profiling of single spermatozoa by using autosomal STRs as well as X- and Y-chromosomal …
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The fundamental interactions between deposits and surfaces at nanoscale using atomic force microscopy
… To compare the measurements from the AFM and micromanipulation to see the differences and similarities. The micromanipulation technique was developed to measure the adhesive strength of different deposits. The method uses a T-shaped probe made of stainless steel chip, dimension 30 x 6 x 1 mm …
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Discourses of Widening Participation and Social Inclusion
… challenge’, analysts can examine processes of micromanipulation – the unique ways in which marginalised people or groups raise problems or attempt to influence any agenda. Adopting a Foucauldian genealogical approach I explore the ways in which a specific widening participation initiative, that …
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Measuring acoustic fields in an optical trap
… of acoustic fields, a first step toward acoustic micromanipulation in fluids. The optical trap used throughout this study is carefully characterized. Eccentricity of measured distributions of thermal fluctuations of trapped dielectric spheres is attributed to a large, directional 60 Hz noise …
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A low-cost automated micromanipulator
… of this project is to build a proof-of-concept micromanipulation device that provides similar levels of performance, but at a price in the range of several hundred dollars. We intend to achieve this by utilizing equipment made recently and inexpensively available at low-costs because of the …
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The mechanics of mechanotransduction : analyses of cell perturbation
… element model was developed to simulate cell micromanipulation by magnetocytometry. The model provided a robust tool for analysis of detailed strain/stress fields induced within a single cell or cell monolayer produced by forcing one tethered microbead. On the assumption of structural …
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Impact of morphology and scale on the physical properties of periodic/quasiperiodic micro- and nano- structures
… a wide range of problems, including optical micromanipulation of biological systems [1, 2], 2-pattern photonic crystals [3], integrated optical circuits on an optical chip [4], photonic quasicrystals with the most premier photonic properties to date [5], plasmonics [6], and structure-property …
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Design and optimization of a macro-micro manipulator featuring a 3-UPS compliant parallel mechanism
Micromanipulation in microtechnology is highly needed for microfabrication and biomedical applications. Specifically, high manipulation resolution combined with accurate macromotions plays a more crucial role especially in the production of semi-conductors, assembly of integrated circuits as well …
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Understanding the mechanical strength of microcapsules and their adhesion on fabric surfaces
… polymerisation technique were characterised by a micromanipulation technique. Conventionally, the mechanical strength parameters include microcapsule diameter, rupture force, deformation at rupture and nominal rupture stress (the ratio of the rupture force to the initial cross-sectional area of …
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Highly Sensitive and Selective Gas Sensors Based on Vertically Aligned Metal Oxide Nanowire Arrays
… arrays prepared by microfabrication and in-situ micromanipulation, respectively, have been demonstrated. The sensors based on WO3 nanowire arrays can detect 50 ppb NO2 with a fast response; well-aligned CuO nanowire array present a new detection mechanism, which can identify H2S at a …
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Custom-Designed Biohybrid Micromotor for Potential Disease Treatment
… as promising candidates for untethered micromanipulation and targeted cargo transport. Their future application is, however, hindered by the low efficiency of drug encapsulation and their poor adaptability in physiological conditions. To address these challenges, one potential solution …
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The pathogenesis of classical Hodgkin lymphoma : investigation of possible viral pathogens and recurrent chromosomal imbalances
… developed techniques for the selection and micromanipulation of single HRS cells from tumours, and the development of molecular cytogenetic techniques (i.e. array-comparative genomic hybridisation (CGH) are overcoming these difficulties. To investigate a potential candidate virus, DNA …
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Sensorless adaptive optics in advanced microscopy techniques
… has been implemented in systems for imaging and micromanipulation whose performance degrade with increasing penetration depth due to refractive index mismatch. With a focus on optical trapping and nonlinear microscopy, the combination of a deformable membrane mirror and a random search …
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Micro-led based optoelectronic tweezers
Micromanipulation tools are a valuable component of biomedical research. A fundamental example is in the study of the complex pathways involved in disease progression in which controlling immune cell interactions at a single-cell level is crucial to the discovery of new treatments. Current cell …
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Hybrid optical and acoustic trapping
The need for non-contact micromanipulation methods is apparent for a number<br/>of different applications. Optical tweezers, a technique which uses highly focused laser beams to trap and move microscopic objects, has become an important tool for many applications owing to its incredible precision …
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