Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 85 for “"Microglial Activation"”.
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Microglial activation and regulation by secreted chaperones
… if so, it is unclear whether and how they affect microglial functions when present extracellularly. Microglia are the primary innate cells of the CNS and one of the first cell types to respond to signs of injury or inflammation. However, the mechanisms that mediate and regulate this early immune …
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The involvement of microglial activation in schizophrenia
Abnormal activation of brain microglial cells is widely implicated in the pathogenesis of schizophrenia. The disrupted balance of microglia phenotypes has been hypothesized to influence the clinical course of the disease and affect symptom severity. Previously, the pathophysiology of microglial …
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Role of Neuraminidase-mediated Desialylation in Microglial Activation
… Research in the recent years however has linked microglial activity to neurodegenerative processes brought about by excessive phagocyto- sis of viable neurons or synapses and the release of proinflammatory cytokines. Microglia require certain on or off signals that induce or reduce their …
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Microglial activation in the harlequin mouse retina as a mechanism for early retinal degeneration
… a marker of both increased inflammation and microglial activation. In situ immunohistochemistry showed greater numbers of activated resident microglial cells present in the harlequin versus wild type mouse retina at a young age. A parainflammatory response as an early disease mechanism opens …
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Unraveling dual dysfunction in Friedreich’s ataxia: how mitochondrial dysfunction and microglial activation drive neurodegeneration
… interplay between mitochondrial dysfunction and microglial activation. By identifying these dysfunctions, this research aims to provide an in-depth understanding of disease and provide insights into novel therapeutic approaches.
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THE ROLE OF IL-¿¿1 RECEPTOR-¿¿ASSOCIATED KINASE 4 IN MICROGLIAL ACTIVATION IN ALZHEIMER’S DISEASE
… and CD14. The role of individual TLRs in the microglial response to A¿¿ has been controversial. Therefore we elected to inactivate the first kinase activated after TLR ligation, interleukin-¿¿¿1 receptor-¿¿associated kinase 4 (IRAK4), to investigate the role of all TLRs in the microglial …
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The Role of Tumor Necrosis Factor (TNF) in Microglial Activation and Progressive Degeneration of Dopaminergic Neurons
… deficits. Given the potential contribution of microglial activation to PD and the suggestion that anti-TNF therapies in the CNS may exert neuroprotective effects on vulnerable dopaminergic neuron populations, I also investigated the role of TNF in regulating microglia effector functions to …
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Micrornas As A Therapeutic Target to Regulate Microglial Activation In Post Stroke Isolation In Aged Male Mice
… non-coding RNAs, have been shown to regulate the activation of microglia from a resting state to “disease-associated microglia (DAM)”. Preliminary work in the laboratory has shown post-stroke SI significantly alters miRNA profiles in the brain. Targeted miRNA-based therapies reduced …
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Astrocytes down-regulate microglial inflammatory responses
… cultured astrocytes are capable of suppressing microglial activation. However, brain injury affect not only microglia but astrocytes. Therefore, I examined how astrocytes in injury states modulate microglial activation. Astrocytes were treated with oxygen-glucose deprivation (OGD) or hydrogen …
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Mechanisms of microglia induced retinal degeneration
… patientswith retinal neurodegenerative diseases. Microglial activation is known to play animportant role in neuroinflammation and neurodegeneration. However, there is adebate on whether microglial activation is the primary cause or a consequence ofretinal neurodegeneration. It is also unclear why …
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Molecular and Genetic Analysis of Parkin in Microglia Activation and Inflammation-Related Neurodegeneration
… can be significantly attenuated by impairment of microglial activation. In addition, previous studies from our lab reported that parkin-/- mice are more susceptible to inflammation-induced degeneration of nigral DA neurons. Therefore, inflammatory responses are a critical determinant of DA …
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Glia-mediated mechanisms of HIV-1-gp120-induced Synaptic Degeneration
… synaptic degeneration. Because gp120 induced microglial activation, we further tested the hypothesis that microglia contribute to gp120-induced synaptic degeneration. We found that blockage of microglial activation abolished the synapse loss induced by gp120. Fractalkine (FKN; a.k.a.CX3C …
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THE ANTI-INFLAMMATORY AND PRO-NEUROGENIC ROLE OF PPARα IN MODULATING RADIATION-INDUCED BRAIN INJURY
… hippocampal neurogenesis and inhibiting microglial activation following WBI represent key strategies to minimize WBI-induced morbidity. Peroxisomal proliferator-activated receptors (PPARs) are ligand-activated transcription factors that possess anti-inflammatory properties. We hypothesize …
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Neuroprotective Effect of Human Mesenchymal Stem Cell on Dopaminergic Neurons by Anti-inflammatory Action
… treatment significantly decreased LPS-induced microglial activation and production of pro-inflammatory cytokines compared to LPS-only treatment group. In co-culture cells of microglia and mesencephalic dopaminergic neurons, hMSCs treatment resulted in a significant reduction of dopaminergic …
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Acute, Low-Grade Inflammation elevates White Matter Sensitivity to Ischaemia
… acute, low-grade inflammation, with limited microglial activation but no axo-myelinic damage. However, acute, low-grade inflammation elevated stress to oligodendrocytes which, when put under ischaemic conditions, impaired their ability to maintain healthy myelin. This increased axo-myelinic …
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Role of Microglial α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulator in Neuroinflammatory Pain Models in Mice
… and processing, and is densely populated with microglial cells and α7 nicotinic acetylcholine receptors (nAChRs). Given the role of microglial α7 nAChRs in neuroinflammation, the α7 nAChRs have emerged as potential target for neuroinflammatory pain treatment. We hypothesized that microglial α7 …
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Quantitative Proteomic Methodology Use and Development to Characterize Ethanol Modulation of Microglial Function
… as the frontline immune defense in the brain. Microglial responses can be either neurotoxic, through the release of reactive oxygen and nitrogen species and inflammatory cytokines, or neurotrophic. Microglial activation due to chronic ethanol exposure has been implicated in neuroinflammation. …
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RADIATION-INDUCED INFLAMMATORY MARKERS OF BRAIN INJURY ARE MODULATED BY PPARä ACTIVATION IN VITRO AND IN VIVO
… oxidative stress responses, as well as increased microglial activation in the brain. Anti-inflammatory drugs may, therefore, be a beneficial therapy to mitigate radiation-induced brain injury. We hypothesized that activation of peroxisomal proliferator activated receptor delta (PPARä) would …
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Bridging the lesioned spinal cord using hydrogel
… cord injury 10 2. Hydrogel injection suppress microglial activation 4 week after injection 14 3. Remodelling of extracellular matrix by I-5 injection 16 4. Matrixmetallo-proteinase-9 ( MMP-9) involved in ECM remodelling 20 5. Perivascular fibroblasts are a major source of the newly formed ECM …
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In vivo pathology markers in tauopathies: prognostic and diagnostic implications
… the PET ligand [11C]PK11195 PET as a marker of microglial activation, and [18F]AV-1451 PET to quantify tau pathology (or in the case of frontotemporal dementia, tau and/or TDP-43 pathology), with structural 3T MRI as an index of atrophy. In patients with Alzheimer’s dementia (n=12) and its …
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