Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 81 for “"Microfluidic channels"”.
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Flow-Through Electroporation in Asymmetric Curving Microfluidic Channels
… new electroporation methods conducted in microfluidic devices. In microfluidic-base electroporation, exogenous macromolecules can be delivered into cells continuously. Flow-through electroporation systems can overcome the issue of low sample volume limitation. In addition, in our method, …
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Study of mechanical effects of microfluidic channels in microneedles
… question the effect of the integrated microfluidic channels on the mechanical integrity of these probes. We have developed a set of tools to help us answer this question. We built an analytical model to predict the mechanical strength of a probe and used that backbone to answer the inverse question …
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Immiscible liquid-liquid displacement in microfluidic channels : effects of wettability and geometry
… from interactions in oil-water-rock systems. Microfluidic devices, micromodels, have been proposed as experimental test beds for reproducing flows in oil reservoirs in laboratory environments since they offer fine control over geometry and chemistry, and therefore provide insights into their …
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Fundamental studies towards the fabrication of electroactive monolithic stationary phases in microfluidic channels
… advantages of EMLC, monolithic technology and microfluidic separation, thus creating an electroactive monolithic microchip (EMμ). In this thesis, fundamental studies towards the fabrication of EMμ are presented, i.e. integration of an electrochemical cell into a microfluidic chip, colloidal …
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Process Characterization of the Reactive-Ion Etching of Borosilicate Glass for Microfluidic Channels
… and society as a whole. Typically, these microfluidic devices are fabricated using polydimethylsiloxane (PDMS). Although it is optically clear, relatively inert, and easy to manipulate, PDMS does have its limitations. These include its tendency to swell when it comes in contact with …
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Design of multiple constriction ratio microfluidic channels for 3D insulator based dielectrophoretic chips
Insulator based dielectrophoresis (iDEP) is a technique used for sorting microparticles based on their electrical properties which proves to be promising in its development. Using multiple constrictions of area to generate gradients of electric fields allows a device to be made without electrode …
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Acoustic resonators with integrated microfluidic channels for ultra-high Q-factor: a new paradigm for in-liquid gravimetric detection
… gravimetric detection. We constructed rigid microfluidic channels to confine liquids and the associated acoustic energy, thereby eliminating acoustic radiation damping. We also used the channels' side walls to create pressure waves, confining the liquids within and suppressing acoustic …
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Components and Technology Development for Personal Diagnostics Laboratory
… in the last chapter. This device is composed of microfluidic channels, valves, mixers, and liquid presence sensors. The device is tailored to perform a cell lyses protocol. This involves precise metering and transportation of biological reagents which was achieved through a number of microfluidic …
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Microfluidic flow of colloidal particles in nematic liquid crystals
… crystal flow for a wide range of parameters in microfluidic channels and ducts. We study the change in structure of defects and molecular orientation around a static particle, particle migration in microfluidic channels, morphology of Saturn ring defects and director structure in ducts of …
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Turning Tears into Sweets: CandyCollect for Pediatric Salivary Pathogen Sampling
Open microfluidic channels are gaining widespread use in biotechnology, biology, and diagnostics due to their broad applicability and user-friendly design, which enables easy addition or removal of components. Chapter 1 reviews capillary-driven open microfluidic systems and the implementation of …
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Principles of Laser Alignment in Atomic Force Microscopy and its Potential Application for Nanoscale 3D Printing
… which has been adapted to an AFM probe with microfluidic channels. The construction process involved building and aligning the optics system, testing the optics sensors, assembling the entire AFM system, creating the user interface, coding, and testing the position controllers. The developed …
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Integrated silicon field-effect sensors and microfluidics for biomolecular detection
… sensors with integrated poly(dimethylsiloxane) microfluidic channels have been demonstrated. These devices are designed for the label-free detection and recognition of specific biomolecules such as DNA. Label-free methods eliminate the time-consuming and costly step of tagging molecules with …
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Protein -Lipid Interactions in Soluble Nanoscale Lipid Bilayers
… to rapidly pattern and assay Nanodiscs using microfluidics was developed. The technique uses microfluidic channels to pattern rows of Nanodiscs on a glass slide, and then deliver multiple analytes in perpendicular rows to create a ""matrix"" assay. This successfully characterized the binding …
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Integrated microfluidics, heaters, and electronic sensors for Lab-on-a-Chip applications
Microfluidics, microfabricated suspended heaters and electronic field effect sensors have been successfully integrated on a single device chip. This integration enables spatial cycling of as little as 11nL of reagents over different thermally isolated temperature zones, to be coupled with the field …
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Fabrication, Metrology, and Transport Characteristics of Single Polymeric Nanopores in Three-Dimensional Hybrid Microfluidic/nanofluidic Devices
The incorporation of nanofluidic elements between microfluidic channels to form hybrid microfludic/nanofluidic architectures allows the extension of microfluidic systems into the third dimension, thus removing the constraints imposed by planarity. Measuring and understanding the behavior of these …
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Multiplexed Electrospray Emitters for Highly Conductive and Corrosive Fluids
… To this end, we modeled the dimension of microfluidic channels that introduce flow impedance overwhelming surface tension at the nozzle tip. We presented laser microfabrication techniques for fabricating two typical types of microfluidic channels: the through-hole array on conductive …
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Silicon processing for microfluidic neuroprobes
… describes the fabrication process of a novel microfluidic-based neuroprobe capable of obtaining neuromodulators with high spatial and temporal resolution with limited tissue damage. This is achieved through the use of microfluidic channels with dimensions in the range of tens of microns, which …
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Integrated microlenses and multimode interference devices for microflow cytometers
… methods. Manipulation of a free optical beam in microfluidic channels is identified as a major need to be able to realise more complex µflow cytometry detection systems. To achieve this, the integrated optics requires substantial advances. The approach in this thesis was to produce a microfluidic …
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THE EFFECT OF CONFINEMENT ON T-LYMPHOCYTE UPSTREAM MIGRATION UNDER SHEAR FLOW
… T cells confined within microcontact printed and microfluidic devices. In the first aim, we explore the microcontact printing conditions to confine T cells within printed ICAM-1 patterns and support upstream migration. We determined directly inking and printing a 50:50 mixture of ICAM-1 and …
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