Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 75 for “"Microfluidic System"”.
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Toward a microfluidic system for proteomics
… has been much interest in the application of microfluidic systems to proteomics in recent years. This is because of the many unique advantages afforded by the reduced dimensions of microfluidic systems compared to classical methods. The reduction in the reaction vessel dimensions leads to a …
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Integrated Microfluidic System for Digital Detection of Extracellular Vesicles
… and to study their heterogeneity. We propose a microfluidic platform for capture of EVs and digitally detect them with the help of a digital microarray and a smart actuation device for sealing the microwells. The chip achieves the EV quantification by digital Enzyme-Linked Immunosorbent Assay …
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Physics and Applications of a PDMS Based Centrifugal Microfluidic System
… this research work is to develop a centrifugal microfluidic system for general purposes based on microfabrication technologies including SU-8 photolithography, polydimethylsiloxane (PDMS) casting. The main contribution of this research is to integrate a flyball governor system into the polymer …
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A Capillary-Based Microfluidic System for Immunoaffinity Separations in Biological Matrices
… analysis times. A prototype capillary-based microfluidic system has been developed for immunoaffinity separations in biological matrices with laser-induced fluorescence detection of labeled antigens or antibodies. The laboratory-constructed device was assembled from two micro syringe pumps, a …
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Development of a portable microfluidic system for monitoring ions river water
… model is to have an in situ monitoring system that provides high frequency screening and monitoring of nutrients in surface water. At present, the conventional in situ monitoring systems available are too cumbersome, expensive and laborious.The main aim of this project was to develop a …
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Design, Fabrication, and Testing of a 3D Printer Based Microfluidic System
<p>A pneumatically actuated PDMS based microfluidic devices were designed and fabricated by soft-lithography. Two types of molds were fabricated out of different material for this experiment. The first mold, (device 1), was fabricated from a sheet of Polymethyl methacrylate (PMMA) material, similar …
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Design and Development of a Portable Microfluidic System for Medical Diagnostics
… towards the development of a portable LOC system for medical diagnostics. A modular microfluidic LOC architecture is presented along with its implementation in two successive generations of devices. The architecture allows for rapid prototyping and simple design changes at low cost. Next, …
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Development of an automated microfluidic system for the loading and unloading of cryoprotectants from mammalian oocytes
… and from the oocyte is described. By combining microfluidics, automation, and optical measurement systems, the proposed system aims to overcome the challenges inherent to manual vitrification, and improve upon other existing platforms designed to perform these tasks. Development and fabrication …
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Development of a PDMS Based Micro Total Analysis System for Rapid Biomolecule Detection
<p>The emerging field of micro total analysis system powered by microfluidics is expected to revolutionize miniaturization and automation for point-of-care-testing systems which require quick, efficient and reproducible results. In the present study, a PDMS based micro total analysis system has …
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Microchemical systems for the synthesis of nanostructures : quantum dots
… multi-stage high-temperature and high-pressure microfluidic system. High-pressure conditions enabled the use low molecular weight solvents that have previously not been available for quantum dot (QD) synthesis such as hexane or octane. The use of supercritical phase provided excellent mixing, …
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Chip Scale Integrated Optical Sensing Systems with Digital Microfluidic Systems
… environment. Miniaturized and portable sensing systems are especially important for medical and environmental diagnostics and monitoring applications. Chip scale integrated planar photonic sensing systems that can combine optical, electrical and fluidic functions are especially attractive to …
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Structural and functional investigation of the trabecular outflow pathway
… ex vivo ocular perfusion as well as in vitro microfluidic systems. In the first study, we investigated the effects of Y27632, a derivative of Rho-kinase inhibitor that is being developed as next generation glaucoma drug with unclear IOP lowering mechanism, on aqueous humor outflow dynamics and …
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3D cyclic olefin copolymer (COC) microfluidic chip fabrication using hot embossing method for cell culture platform
A microfluidic system has been developed for studying the factors inducing different responses of cells in vascular system using a three-dimensional microenvironment. The devices have been transferred from PDMS to a platform in cyclic olefin copolymer (COC) which has advantages in terms of …
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Turning Tears into Sweets: CandyCollect for Pediatric Salivary Pathogen Sampling
Open microfluidic channels are gaining widespread use in biotechnology, biology, and diagnostics due to their broad applicability and user-friendly design, which enables easy addition or removal of components. Chapter 1 reviews capillary-driven open microfluidic systems and the implementation of …
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Microfluidic systems for cell transfection using sonoporation and electroporation
… in recent years. This research presents a microfluidic system for cell transfection using sonoporation and electroporation. This research has studied, designed, developed and tested the sonoporation system and electroporation system with certain biological cells. Ultrasonic standing waves, …
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A microfluidic platform for three-dimensional neuron culture
… to the cells. In this study, we present a microfluidic system to address the limitations of previous research.
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Physical Factors Regulating Human Trophoblast Invasion
… (3D) was first established. This system offers significant benefits compared with two-dimensional (2D) systems used previously. Importantly, only cells expressing the HLAG antigen, a marker for the extravillous phenotype are analysed. The stiffness of decidual tissues at the …
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In vitro study of cancer cell extravasation in microfluidic platform
… the primary tumor, intravasate into the vascular system and eventually transmigrate across the endothelium into to a secondary site through a process of extravasation. Microfluidic systems have a major advantage in studying cancer extravasation since they can mimic aspects of the 3D in vivo …
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A microfluidic mucosal airway model to study airway mucosal function and pathogenesis
… In this thesis, we develop a novel in-vitro microfluidic system which closely models the biophysiological properties of the airway system. Our system accommodates co-current flow of aerosol and mucus and reproduces the key physiology of molecular and particle transport into a mucus barrier. A …
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