Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 223 for “"Microfluidic Device"”.
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Microfluidic device for cytotoxicity screening
… resource-intensive process. We have developed a microfluidic device with internal structures that can evenly distribute cells across five chambers and requires only microliter volume of cell culturing media. In this study, we performed fluid dynamic simulations of different microfluidic designs …
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Magnetostatic Modeling for Microfluidic Device Design
<p>Magnetostatic Modeling for Microfluidic Device Design</p> <p>Kirsten Marie Jackson</p> <p>For several years, biologists have used superparamagnetic beads to facilitate biological separations. More recently, researchers have adopted this approach in microfluidic devices [1-3]. This recent …
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Digital Manufacturing Techniques for Microfluidic Device Fabrication
Microfluidic devices are currently used in a wide range of scientific and biomedical areas such as tissue engineering, cell biology, and implantable devices. Lab-on-a-chip research utilizing microfluidic devices has advanced significantly over the last decade and provides advantages of …
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Application of microfluidic device to malaria diagnosis
Of many diagnostic devices and technology developed, microfluidics could be superior in terms of ease of fabrication, cost, portability, speed and sensitivity. The application of diagnosis of malaria infection by microfluidics is studied. Malaria infected red blood cells will cause a cell …
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A passive microfluidic device for continuous buffer exchange
… sample viability. Herein is presented a microfluidic device that passively moves cells from a high-conductivity growth media into a low-conductivity DEP buffer. It is comprised of con- verging rows of pillars and uses mechanical filtration to force cells into the new buffer while allowing …
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Integrated DNA extraction and amplification on a microfluidic device
… of DNA extraction and amplification performed in microfluidic systems was carried out, with the aim of integrating the two processes in a single microfluidic device. This integrated device will then be incorporated upstream of capillary gel electrophoresis and fluorescence-based detection for …
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A Passive Microfluidic Device for Buffer Transfer of Cells
… in viability. In this work, a lab-on-a-chip device is proposed that uses a textit{passive microfluidic approach} to effectively transfer cells from a growth medium to a desired buffer for downstream cDEP analysis. This eliminates the need for any external fields, expensive equipment, and …
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Microfluidic device and interfacial transport: application to biomolecules and nanostructures
… is to provide new knowledge and applications of microfluidics in a variety of problems, from materials science, devices, and biomedicine, where the control on the fluid dynamics and the local concentration of the solutions containing the relevant molecules (either materials, precursors, or …
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Vertical hydrodynamic focusing in an isotropically etched glass microfluidic device
The development of microfluidic devices has enabled precision control of nanoliter-scale environments and reactions. Vertical hydrodynamic focusing is one possible way to improve the optical performance of these devices while maintaining precision control. Vertical hydrodynamic focusing was studied …
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Development of a microfluidic device for blood oxygenation by photocatalysis
… acute or chronically disabled lungs. A novel microfluidic device for the oxygenation of whole blood has been developed. The device couples a semiconductor, titanium dioxide (TiO₂), thin film that generates oxygen through photocatalysis with a microfluidic network that facilitates diffusion of …
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Tapered microfluidic device for multi-particle separation based on sedimentation principle
This thesis presents a label-free tapered microfluidic device for a passive multi-particle separation. Separation process plays a significant role in various industries for example, biomedical diagnostic, food processing and substance purification. The growing needs for continuous separation …
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Programming of wicking behavior of hydrogel and paper-based microfluidic device
Paper-based microfluidics (μPADs) have been a popular choice as lateral flow tests (LFTs) platform for diagnostic purpose because of its ease of use, speed, affordability, and spontaneous fluid transport based on an intrinsic property of material. Recent developments have rapidly increased the …
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High Throughput Centrifuge Microfluidic Device for Simultaneous Particle Separation and Solution Exchange
Microfluidic centrifuge devices have gained increasing attention for point-of-need (PoN) sample preparation processes, e.g., in separation or solution exchange of various microparticles, bacteria, and mammalian cells. Yet, those devices capable of simultaneous solution exchange and particle …
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A Microfluidic Device for Transfection of Mammalian Cells Using Adjustable Shear Stress
Microfluidic technology is a rapidly progressing tool in biomedical engineering. Microfluidic devices are appreciated for their simplicity and production efficiency potential. Our research focuses on developing a microfluidic device capable of transfecting cells by applying shear stress to cause …
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Sparse Sample Detection Using Magnetic Bead Manipulation on a Digital Microfluidic Device
… uses magnetic bead manipulation on a digital microfluidic device. Sparse sample detection was made possible through two steps: sparse sample capture and fluorescent signal detection. For the first step, the immunological reaction between antibody and antigen enables the binding between target …
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Characterization of the photochemical etching process: an alternative microfluidic device fabrication method
… an alternative to fabricate the master mold of a microfluidic device. During this process, a semiconductor substrate is submerged in an etchant solution. Structures are then etched into its surface based on the image formed by a commercial projector. Once characterized and optimized, PC etching …
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Design, Fabrication and Characterization of a Microfluidic Device for Ultrasound-based Cell Sorting
… traveling waves and microbubble tags. A microfluidic device consisting of a flow channel was developed for effectively performing MiCS. The device was designed with the aim of obtaining traveling waves in the flow channel by using various design considerations and Finite Element Analysis …
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Development of a centrifugal microfluidic device for separation and sorting in biological fluids
… and fast diagnosis times make centrifugal microfluidic devices an attractive option in patient-side diagnostics. Some essential tasks to be performed in microfluidic devices are sample-reagent transport, mixing, separation and detection. All these tasks require precise control of the RPM …
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Modeling and control of rapid cure in polydimethylsiloxane (PDMS) for microfluidic device applications
… is an important thermosetting elastomer for microfluidic devices because it can replicate nano-scale features and form flexible membranes useful for microactuation. PDMS is used extensively in research environments because it is readily available and biocompatible. However, the prototyping …
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Role of von Willebrand factor in shear induced platelet accumulation in a microfluidic device
… shear thrombosis, the present work developed a microfluidic thrombosis assay to meet low blood volume requirements and fluid shear conditions (3500-6000 s-1). Microfluidic conditions were selected to mimic the high shear environment of a diseased coronary artery, with the long-term objective of …
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