Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 209 for “"Microenvironments"”.
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Protein microenvironments for topology analysis
… a system that could efficiently compute microenvironments such that they can be applied routinely to large datasets. Thecomputation of the microenvironments was the most challenging aspect in termsof performance, and the optimisations required are described.Methods of scoring …
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Defining cellular microenvironments using multiphoton lithography
… on the development of methods to define cellular microenvironments using the high resolution, 3D capabilities of multiphoton lithography. Here, site-specific photochemistry using multiphoton excitation is applied to the photocrosslinking of proteins, providing the means to organize bioactive …
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Regulation and inhibition of pro-tumorigenic microenvironments
… target for the inhibition of tumor-promoting microenvironments in general, not just those containing senescent fibroblasts. Indeed, cancer-associated fibroblasts (CAFs), which promote tumor growth through an altered gene expression profile similar to the SASP, are dependent upon p38MAPK …
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MODULATING CELL DIFFERENTIATION WITH PROTEIN-ENGINEERED MICROENVIRONMENTS
… utilizes biomaterials that mimic native cellular microenvironments and provide environmental cues to induce specific cell responses, including differentiation. Biochemical and biophysical cues modulate cell behavior and direct construction of specific types of tissue. Thus, this work describes …
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The development and function of thymic microenvironments
The thymus is organised into distinct microenvironments, and trafficking through these regions enables thymocytes to receive essential signals for the generation of a diverse and self-tolerant T-cell repertoire. Thymic epithelial cells (TEC) represent a key stromal cell type during defined stages …
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Engineered microenvironments for studying liver progenitor differentiation
The bipotential differentiation of liver progenitor cells underlies liver development and bile duct formation as well as liver regeneration and disease. Both TGFβ and Notch signaling are known to play important roles in the liver progenitor specification process and subsequent tissue morphogenesis. …
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Cell-cell communication in three dimensional microenvironments
Cellular behavior is dependent on a variety of extracellular cues required for normal tissue function, wound healing, and activation of the immune system. Removed from their in vivo microenvironment and cultured in vitro, cells lose many environmental cues and that may result in abberant behavior, …
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Aquatic microenvironments in bacterial ecology and diversity
… This study examines the role of aquatic microenvironments in generating bacterial diversity: closely related organisms may co-exist in the same environment without competing for resources by a combination of habitat, metabolic, and behavioral differentiation. This hypothesis has been …
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Capturing Complex Microenvironments for Directed Stem Cell Differentiation
… Using this technique, we identified several microenvironments supporting MSC adhesion, spreading and differentiation toward early vascular lineages. This portion of the thesis supports the hypothesis that a complex milieu exists coupling protein functional behavior with substrate rigidity and …
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MECHANISTIC STUDY OF AQUAPORINS BEHAVIOR UNDER DIFFERENT MICROENVIRONMENTS
Water is a valuable resource as a driver of life and economies. With water shortage being recognized as a global problem, alternative methods of water production are critical to support human activities. A recent development in the application of Aquaporins (AQPs) has revealed its tremendous …
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Investigation of cellular microenvironments and heterogeneity with biodynamic imaging
<p>Imaging of biological tissue in a relevant environment is critical to accurately assessing the effectiveness of chemotherapeutic agents in combatting cancer. Though many three-dimensional (3D) culture models exist, conventional <em>in vitro</em> assays continue to use two-dimensional (2D) …
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Programmable Assembly of Elastin-like Polypeptides Within Droplet Microenvironments
… proteins, into model organelles within droplet microenvironments. We synthesized a library of recombinant elastin-like polypeptides, and studied their phase separation and assembly into various organelles, from layered to mixed to size-controlled, within water microdroplets using lightfield, …
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Microfluidic platforms for studying cell behavior in complex microenvironments
… advanced platforms capable of mimicking these microenvironments are necessary. Microfluidic platforms have the potential to enable systematic studies of cell behavior in these complex microenvironments. Microfluidic platforms provide control over the chemical microenvironment. This inherent …
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Engineering cellular microenvironments for directed cell growth and migration
… these systems to precisely control the cellular microenvironments and investigate cell behavior in vitro. This work aims at integration of advances in life sciences and microfabrication techniques to address fundamental biological questions underlying cellular behavior. We specifically focus on …
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Illuminating epithelial-stromal communication using engineered synthetic matrix microenvironments
Mucosal barrier tissues are prominent targets for drugs against infection and chronic inflammatory disorders. One such mucosal barrier tissue, the endometrium, undergoes monthly cyclic remodeling via hormone-mediated growth, immune cell recruitment and proteolytic breakdown. Hormone response …
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Dendritic Cell Migration and Traction Force Generation in Engineered Microenvironments
Dendritic cells (DCs) are potent initiators of the adaptive immune response. Their trafficking from sites of inflammation to lymphoid tissue is essential to their function. Exactly how dendritic cells integrate multiple chemotactic cues to organize an accurate migratory path is not fully …
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Characterizing intercellular heterogeneity in tumor microenvironments via infrared spectroscopic imaging
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-12-01
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Transcriptome-wide organization of subcellular microenvironments revealed by ATLAS-Seq
Subcellular localization of RNAs is a ubiquitous and evolutionarily conserved process that provides an additional layer of transcriptome organization promoting coordinated control of gene expression in both space and time. It has been shown to contribute to processes ranging from cell fate …
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3-D Bio-inspired Microenvironments for In Vitro Cell Migration
Cancer metastasis is the leading cause of death related to cancer diseases. Once the cancer cells depart the primary tumor site and enter the blood circulation, they spread through the body and will likely initiate a new tumor site. Therefore, understanding the cell migration and stopping the …
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