Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 110 for “"Microenvironmental"”.
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Mechanisms of microenvironmental paracrine signaling in cancer chemoresistance
Chemoresistance remains a major barrier to the effective treatment of cancer. Cancer therapy occurs in the context of a tissue environment, with cancer cells surrounded by many non-malignant cells that contribute to tumor growth and resistance to therapy. Yet much remains unknown about the tumor …
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The Effect of Microenvironmental Cues on Adipocyte Cytoskeletal Remodeling
… are mechanoresponsive and affected by different microenvironmental cues, including hypoxia and mechanical (un)loading. Yet, no study has focused on the role of the aforementioned factors on the adipocyte mechanical response, including actin cytoskeletal remodeling. This dissertation aims to …
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Microenvironmental and metabolic influences in tumor cell redox homeostasis
… strategies, increased understanding of microenvironmental and metabolic influences in tumor cells redox homeostasis is needed. Poorly arranged and malfunctioning vasculature in the tumor microenvironment causes heterogeneous regions of hypoxia to form throughout the solid mass. …
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Roles For Braf Kinase Activating Mutations In Melanoma: Microenvironmental Immunosuppression
<p>The BRAF oncogene demonstrates a characteristic mutation (V600E) in a significant fraction of cutaneous melanomas, leading to constitutive activation of the MAP kinase pathway. This genetic lesion endows tumor cells with proliferative and survival advantages, and metastatic melanoma patients …
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Microenvironmental Modulation of Breast Cancer Stem Cells Through Biological Matrix
… The results presented in this work that the microenvironmental cues play a considerable role in tumor relapse and progression by altering the cancer stem cell behavior and thus this knowledge could be used to design novel cancer therapeutics. </p> <p>In chapter one, we define the cancer stem …
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Microenvironmental modification and analysis of 3D cell culture using microgels
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-08-01
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Effect of Tumor Microenvironmental Conditions on Non Small Cell Lung Cancer
<p>Tumor microenvironmental conditions play a vital role in promoting metastasis and tumor recurrence. Due to inefficient vasculature, cancer cells experience hypoxia, glucose deprivation and low pH even during the early stages of tumor growth. Tumor cells are proposed to adapt to these …
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Bioengineered Submucosa for Studying Effects of Microenvironmental Mechanics on Colorectal Cancer Cells
The tumor microenvironment is a complex space consisting of a number of stimuli such as: stromal cells, signaling and paracrine factors, as well as extracellular matrix (ECM) components. Each of these factors push and pull cancer cells in different directions and the sum of the interactions defines …
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The Role of miR-126/126* in Microenvironmental Regulation of Cancer Metastasis
<p>Cancer metastasis is the cause of about 90% of cancer patients' deaths. Despite significant improvements in the past three decades in understanding the molecular bases of oncogenic transformation of cancer cells, little is known about the molecular mechanisms underlying tumour cells' alteration …
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Dissecting cell-autonomous and microenvironmental factors governing lymphatic metastasis in breast cancer
Metastasis is the primary cause of deaths in cancer patients. Tumour dissemination can occur through the bloodstream or lymphatic system. The presence of tumour cells in the draining lymph node (lymph node involvement) represents the most important prognostic factor for breast cancer patients. …
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Investigating the role of geometry, mechanics, and microenvironmental cues on liver progenitor cell differentiation
Engineered systems permit investigation of the variety of signals in the microenvironment that direct cells and tissue fates. This work focuses on developing and using such systems to investigate how mechanical characteristics impact liver progenitor cell differentiation. In this dissertation, I …
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Dissecting combinatorial microenvironmental regulation of cell fate and function using a multi-modal arraying platform
… systems provide a means of deconstructing the microenvironmental cues which guide cell fate and function. These cues can include biochemical elements, as in ligand–receptor binding for cell–cell or cell–extracellular matrix (ECM) interactions, or responses to biophysical parameters, as in cell …
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Tumor microenvironmental control of metastasis : effects of the immune cells and physical forces on cell migration
Metastasis, which accounts for 90% of cancer deaths, critically depends on the ability of cancer cells to migrate through the dense extracellular matrix (ECM) surrounding the solid tumor. Recent advances in cancer biology have revealed that non-cancerous cells and biophysical forces in tumor …
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The Effect of Microenvironmental Space on Communication and Job Satisfaction in an Office Environment: A Systematic Enquiry
… a questionnaire investigating the impact of microenvironmental space on communication and job satisfaction. Data was analyzed using quantitative research methods. The results showed that a distinct lack of conversational privacy existed in this office. Also, when the level of noise decreased, …
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Deconstructing the influences of combinatorial microenvironmental cues on human non-parenchymal liver cells in models of liver fibrosis
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-05-01
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Modeling the Heterogeneous Brain Tumor Microenvironment to Analyze Mechanisms of Vascular Development and Chemoresistance
… has motivated further investigation into how microenvironmental factors could contribute to tumor initiation, development, and therapeutic resistance. Analyzing how the microenvironment drives tumor development and cancer cell heterogeneity is particularly important in cancers such as …
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The effects of biophysical and biochemical cues on tendon cells: a study of underlying mechanisms in tendinopathy
… disorders and is associated with the tendon microenvironmental changes, including disordered matrix structures, reduced stiffness and altered biochemical signalling. The effect of these microenvironmental cues on tendon cells and tendinopathy progression is poorly understood. Hypothesis: The …
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Engineering scaffold and soluble cues for cell-instruction
… tissue engineering approach that combines microenvironmental scaffold cues with soluble factor cues so as to enhance cell-instruction and tissue regeneration. In order for this aim to be accomplished, we started off by separately examining the control of microenvironmental cues and the …
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