Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Microelectrode arrays (MEAs)"”.
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Functional and Categorical Analysis of Waveshapes Recorded on Microelectrode Arrays
… cell cultures grown on substrate integrated microelectrode arrays (MEAs) generate spontaneous activity that can be recorded for up to several weeks. The signature wave shapes from extracellular recording of neuronal activity display a great variety of shapes with triphasic signals …
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Development Of Single And Array Electro-Chemical Sensors For Real-Time Trace Metal Analysis In Aqueous Environmental Media
… cyclic voltammetry (FSCV) at carbon-fiber microelectrodes (CFMs) to achieve rapid measurement of metal ions with high sensitivity, selectivity, and stability. Through optimizations this method showed strengths in real-time trace metal analysis. </p> <p>Analytical selectivity was …
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Statistical analysis of neuronal data: Development of quantitative frameworks and application to microelectrode array analysis and cell type classification
… neuronal network activity recorded on microelectrode arrays (MEAs). I perform an unbiased evaluation of the existing techniques for detecting ‘bursts’ of neuronal activity in these types of recordings, and provide recommendations for the robust analysis of bursting activity in a range …
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Glutamate Dysregulation in a TauP301L Mouse Model of Alzheimer's Disease
… we used an amperometry coupled to ceramic-based microelectrode arrays (MEAs), which allows for measurement of tonic glutamate levels, potassium-evoked glutamate release, and glutamate clearance from the synapse. P301L tau expression did not affect tonic extracellular glutamate levels or clearance …
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Development Of Carbon Based Neural Interface For Neural Stimulation/recording And Neurotransmitter Detection
… have generated tremendous interests. CNT based microelectrode arrays (MEAs) have shown enhanced electrochemical properties compared to commonly used electrode materials such as tungsten, platinum or titanium nitride. On the other hand, the soft polymer substrate can overcome the mechanical …
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RAPID FABRICATION OF CUSTOMIZABLE MXENE/POLYDOPAMINE (MXPDA) ELECTRODES
… with polydopamine (PDA) to develop customizable microelectrode arrays (MEAs) that can be rapidly fabricated for use in surgical settings. MXenes are selected for their exceptional conductivity, flexibility, and biocompatibility-qualities essential for effective neural interfaces. The addition of …
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Optimizing Multi-Well Micro-Electrode Array (MW-MEA) Design to Study the Electrophysiology of Neurons
Microelectrode arrays (MEAs) have been widely utilized to measure and study neuronal activities, both in vitro and in vivo. The main focus of this study was to optimize the MEA design to improve the recording efficiency from a group of cells in an area to have a better understanding of what is …
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Graphene Brain on a Chip Platform for the Study of Neurodegeneration
… PD initiate and propagate. Therefore, graphene microelectrode arrays (MEAs) were explored to bridge this gap. However, there are currently no protocols or methods available to fabricate reliably and apply the graphene MEAs for the study of neurodegeneration. This work demonstrates a new …
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Transparent neural interfaces for simultaneous electrophysiology and advanced brain imaging
… in clinical brain imaging. On the other hand, microelectrode arrays (MEAs) and neural probes are indispensable in deciphering the electrical activity of neurons. Unfortunately, simultaneous imaging and electrophysiology is challenging with conventional metal electrodes which are …
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Advancing three-dimensional electrophysiology: Development and evaluation of versatile platform for tailored 3D microelectrode array fabrication
Microelectrode arrays (MEAs) are widely used tools to investigate in vitro neuronal networks and acute brain slices. Planar or 2D MEAs have been the conventional standard for decades, enabling the extracellular recording and stimulation of cultured neuronal cells and tissue slices. However, the …
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Nanostrukturierte Metallelektroden zur funktionalen Kopplung an neuronale Zellen
… cells. Currently, the use of planar microelectrode arrays (MEAs) is an established technique for such extracellular recordings. However, a high impedance and a low signal-to-noise ratio are challenges, which have to be addressed for the recording of high quality measurements with …
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A machine learning approach to spike sorting to reveal neuronal signalling defects in models of neurodegeneration
… networks and the activity of individual neurons. Microelectrode arrays (MEAs) allow for recordings with a high electrode count, generating extensive datasets of neuronal information. Furthermore, MEAs capture extracellular field potentials from cultured cells, resulting in highly complex neuronal …
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MICROELECTRODE ARRAY FOR CAPACITIVE TRANSDUCTION OF RETINAL RESPONSES
… neural activity sensing employ multi-electrode arrays (MEAs) that typically incorporate metal electrodes and measure currents via an electrochemical junction, leading to corrosion and charge transfer across the electrode-tissue interface. High-density neural interface technology will require …