Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 60 for “"Microelectrode arrays"”.
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Functional and Categorical Analysis of Waveshapes Recorded on Microelectrode Arrays
… cell cultures grown on substrate integrated microelectrode arrays (MEAs) generate spontaneous activity that can be recorded for up to several weeks. The signature wave shapes from extracellular recording of neuronal activity display a great variety of shapes with triphasic signals …
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Improved Fabrication and Quality Control of Substrate Integrated Microelectrode Arrays
… neuronal networks cultured on photoetched multimicroelectrode plates (MMEPs) offer great potential for use in studying neuronal networks. However, there are many problems associated with frequent, long-term use of MMEPs. The major problems include (1) polysiloxane insulation deterioration and …
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Listening to neurons - development and understanding of microelectrode arrays (MEA's) systems
This thesis is about the development of microelectrodes array system (MEAs), the simulation of the neuron and the recording to the living neural network. We cultured the nerve cells of rat inside a container called 'neural bathtub' and guided them to form predetermined network (Jude pattern) with …
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Optimization of Cell Culture Procedures for Growing Neural Networks on Microelectrode Arrays
… updated and complete procedures for use with microelectrode array (MEA) recording technology. Specific cell culture protocols, contamination prevention and control, as well common problems encountered within the cell culture facility, are discussed. This volume offers value and utility to the …
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Graphene Microelectrode Arrays to Combine Electrophysiology with Fluorescence Imaging of Amyloid Proteins
… to be combined, a transparent graphene microelectrode array (MEA) was designed, fabricated and characterised. The active electrode site was graphene since it is electrically conductive, optically transparent and biocompatible. The graphene MEA was characterised using Raman spectroscopy …
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Characterizing the material properties of polymer-based microelectrode arrays for retinal prosthesis
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2003.
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Optimising Recording & Stimulation Performance of Neuronal Microelectrode Arrays through Macroporous Conducting Polymer Modification
Microelectrodes are commonly used to interface with electrically active cells, such as neurons (typically as an array of microelectrodes) allowing for their monitoring (recording) and manipulation (stimulation). Recent trends towards smaller electrodes for improved spatial resolution have revealed …
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Technologies for and Electrophysiological Studies of Structured, Living, Neuronal Networks on Microelectrode Arrays
We also recorded neurons patterned by photoresist image transfer and found patterned neurons capable of firing action potentials. Their firing depended on neuronal communication as action potentials were suppressed by high magnesium media. In addition, we found that network activity depended on …
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Optical Nanoantennas Integrated with 3D Microelectrode Arrays: Hybrid Photonic-Electronic Modalities for Nano-Bio Interfacing
… integrated biochemical and bioelectrical sensor arrays to create a multi-modal platform for complex systems biological research. For the biochemical sensor, we introduced a tunable optical nanoantenna that is driven wirelessly by incident laser light (photons) to create a highly localized …
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Examination of UV-Cross-Linkable Di-Block Copolymer Strategy for Functionalized Reaction Surface on Microelectrode Arrays
Microarrays are powerful tools for high-throughput screening of small molecule libraries. Our group is using a microelectrode array variant on these efforts that allows us to construct and screen the libraries in a rapid, cost effective fashion. In this approach, the small molecules are attached to …
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Evaluation of Zinc Toxicity Using Neuronal Networks on Microelectrode Arrays: Response Quantification and Entry Pathway Analysis
… embryonic frontal cortex (FC) tissue grown on microelectrode arrays, were used to investigate zinc toxicity at concentrations ranging from 20 to 2000 mM total zinc acetate added to the culture medium. Continual multi-channel recording of spontaneous action potential generation allowed a …
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Considerations on the use of Impedance Spectroscopy for the Detection of Virions Trapped in Quadrupolar Microelectrode Arrays
The impedance response of a quadrupolar microelectrode array was studied over a wide frequency range to determine whether particles captured at the center of the array could be detected impedimetrically. The microelectrode array (denoted as DEP chip) uses dielectrophoretic forces to concentrate …
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Development of microelectrode arrays for real-time monitoring of alkaline phosphatase release from cells in clinical analysis
… Our integrative approach took advantage of microelectrode arrays technology, facilitating the yield of recordings, signal shape, and signal-to-noise ratio. For the purposes of the research, electrochemical impedance devices had 40 electrodes distributed in 8 wells that facilitated continuous …
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Micro- and nano-electrode arrays for electroanalytical sensing
… of the electrochemical behaviour of two sets of microelectrode arrays, fabricated by standard photolithographic and reactive-ion etching techniques, is presented. The first set of microelectrode arrays had a constant relative centre-centre spacing of 10r (where r is the electrode radius). As a …
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Characterisation of electrode microarrays produced photolithographically and with thiol self-assembled monolayers on gold electrodes
… qualitative advantages. The great advantage of microelectrodes over macroelectrodes is the minimisation of interference, which gives rise to much lower detection limits. Microelectrodes have much reduced ohmic drops and capacitive effects and can be used in the absence of supporting electrolyte. …
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Studies Toward the Development of a Microelectrode Array for Detection of Dopamine Through Redox Cycling
… electrodes. Two or more individually-addressable microelectrodes located close to each other allow redox cycling to be possible. Electrochemical behavior of a biologically important molecule, dopamine is examined under redox cycling conditions. To our knowledge, this is the first report on …
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Development Of Carbon Based Neural Interface For Neural Stimulation/recording And Neurotransmitter Detection
… have generated tremendous interests. CNT based microelectrode arrays (MEAs) have shown enhanced electrochemical properties compared to commonly used electrode materials such as tungsten, platinum or titanium nitride. On the other hand, the soft polymer substrate can overcome the mechanical …
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Electrochemical biosensor based on microfabricated electrode arrays for life sciences applications
… electrochemical sensors can be achieved by using microelectrodes and to modify the electrode surface (using chemical or biological recognition layers to improve the sensitivity and selectivity). The fabrication and characterisations of silicon-based and glass-based gold microelectrode arrays with …
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Concentration-dependent Effects of D-Methylphenidate on Frontal Cortex and Spinal Cord Networks in vitro
… frontal cortex and spinal cord networks grown on microelectrode arrays were used to study effects of D-methylphenidate. These central nervous system tissues have relatively low concentrations of dopaminergic and noradrenergic neurons compared to the richly populated loci, yet exhibit similar …
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