Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 104 for “"Microdialysis"”.
-
Microdialysis to study the Gastrin-ECL cell Axis in the conscious rat
… of the technique of gastric submucosal microdialysis for the study of ECL-cell histamine mobilization in vivo. We found the microdialysis technique to be a reliable tool for the study of the ECL-cell histamine mobilization in conscious rats. Although there was an inflammatory response to …
-
Myocardial ischemia-reperfusion and cardioprotection. A study with microdialysis in a porcine model.
… coronary artery occlusion, utilizing the microdialysis technique, concomitantly with the monitoring of global circulation and local coronary artery flow in an open chest pig model. Myocardial interstitial metabolites demonstrated characteristic, significant, and reproducible changes as …
-
Investigation of Carbamathione Pharmacokinetics and Pharmacodynamics by In Vivo Microdialysis and Capillary Electrophoresis
… and relevant neurotransmitters in rat brain microdialysis samples in order to elucidate the pharmacokinetics and pharmacodynamics of carbamathione. The effect of disulfiram on the brain neurotransmitters was evaluated. The significance of this research is that carbamathione may be involved in …
-
Neurochemical Monitoring in a Humanised Murine Model of Parkinson’s Disease using Amperometry and Microdialysis
… (O2) and hydrogen peroxide (H2O2) coupled with microdialysis sampling. The development of a humanised mouse model of PD provides an invaluable tool in which to study PD in a physiological setting. By application of amperometric sensors and microdialysis sampling in these PD models, the …
-
Investigation of ocular drug metabolism and pharmacokinetics using multi-omics and in-situ microdialysis
Ocular drug disposition is governed by a complex interplay of anatomical barriers, local metabolic activity, transporter expression, and tissue-specific physiological processes. However, quantitative understanding of drug-metabolizing enzymes and transporters in ocular tissues remains limited, …
-
In vitro Microdialysis Sampling Collection of Volatile Organic Compounds (VOC's), Dodecafluoropentane (DDFP) and Isoflurane
… The current in vitro work demonstrates that microdialysis can collect volatile organic compounds, isoflurane (a standard inhalation anesthetic) and DDFP. Different perfusion fluids and flow rates were tested for optimal analyte collection through the microdialysis membrane. Instead of …
-
Dynamic Measurement Of Soluble Human Aβ In A Combined Microdialysis-Experimental Traumatic Brain Injury Mouse Model
… in the brain's extracellular space. A recent microdialysis-based study in human patients with severe brain injuries found that extracellular Aβ dynamics correlate with changes in neurological status. Because neurological status is generally diminished following injury, this correlation …
-
Microdialysis in the study of GABA and other putative amino acid neurotransmitters in the dorsomedial hypothalamus
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
-
The quantification of histamine in the tissue and dialysate of rat brain: measured by microdialysis and radioenzymatic assay
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
-
Development of an in vitro drug recovery model for paediatric tuberculous meningitis using microdialysis with in vivo application
… it is the pharmacologically active component. Microdialysis (MD) is a method that is used in advanced clinical care to measure molecules in tissue, including the brain. It has some limitations, however, including the difficulty of calculating the relative recovery and potential anatomical …
-
Effect of antidepressants and adolescent stress on catecholamine transmission in the rat bed nucleus of stria terminalis (BNST): a microdialysis study
… of this study, carried out by means of in vivo microdialysis, were: (i) ascertain the acute effects that antidepressants with varying mechanisms of action have on dopamine and norepinephrine output in the BNST; (ii) ascertain the acute effects that sub-anesthetic doses of ketamine have on …
-
Amphetamine Sensitization and <em>in vivo</em> Microdialysis of the Nucleus Accumbens Core of Adult Male and Female Rats D2-Primed as Neonates.
… sensitization, cerebrospinal fluid was taken via microdialysis from the nucleus accumbens core and was analyzed for dopamine content. Analysis revealed D<sub>2</sub> priming produced a 300% increase of dopamine release in the nucleus accumbens core in response to amphetamine compared to controls. …
-
CNS Penetration of Tyrosine Kinase Inhibitors in Mouse Models
… <p>In the present study, we used cerebral microdialysis sampling, a technique for sampling unbound molecules in brain extracellular fluid (ECF) via semi-permeable probe, to assess the role of murine ATP Binding Cassette (ABC) transporters Bcrp1, P-gp, and Mrp4 in CNS penetration of …
-
Investigation Of Dopamine Dynamics In Bdnf+/- Mice Using In Vivo Microdialysis And Electrochemical Analysis Of Purine And Monoamine Molecules Using A Boron-Doped Diamond Electrode
… system. Through a series of <i>in vivo</i> microdialysis and slice voltammetry experiments, we have discerned that female BDNF<sup>+/-</sup> mice are hyperdopaminergic similar to their male BDNF<sup>+/-</sup> counterparts. The <i>in vivo</i> microdialysis method zero-net flux highlighted …
-
Electrical stimulation of reward sites in the ventral tegmental area of the rat increases dopamine transmission in the nucleus accumbens as measured by in vivo microdialysis
In vivo microdialysis with HPLC-ED was used to measure dopamine (DA),3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) in the nucleus accumbens of the rat, prior to, during, and after 15-min periods of electrical brain-stimulation at sites in …
-
Contusion Progression in Traumatic Brain Injury
… mediators of this process using intracerebral microdialysis. • Study I: A robust and effective stereological method for measuring the volume of brain lesions was validated and applied to a cohort of TBI patients to examine the temporal course of contusion progression. Intracranial pressure and …
-
Proteomic analysis of interstitial fluid for novel markers of the cutaneous response to injury
… identify novel mediators of the early response. Microdialysis was chosen as both the sampling method and the means by which the tissue was injured as probe insertion causes a single injury that can be sampled continuously without further damaging the tissue.<br/>Early injury responses were …
-
The Effect of Cholecystokinin Antagonist Lorglumide on Dopamine Levels in the Rat Caudate
… in this study using both turnover estimates and microdialysis to evaluate the effects of systemic lorglumide on DA turnover and release in the rat CPu. Turnover estimates based on the depletion of DA following α-mpt or by evaluation of DOPAC/DA ratios failed to reveal a significant difference …
Page 1 of 6