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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 90 for “"Microchip"”.
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Controlled release microchip
Microchips for constant release are not a new concept, but a controlled release chip, which does pulsatile release at variable time intervals, is clearly more efficient and useful. The process was completely understood about the theory of operation, the manufacturing procedure and the robustness of …
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A controlled release microchip
… were to design, fabricate, and characterize a microchip capable of achieving both pulsatile and continuous release of multiple chemical substances on demand. Each prototype microchip consisted of an array of reservoirs etched into and extending through a silicon wafer. Each reservoir was …
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Nd:YVO4 microchip lasers and amplifiers
An investigation of microchip laser and amplifier systems using the material Neodymium doped Yttrium orthovanadate (Nd:YV04) has been performed. This project takes advantage of recent improvements in the growth of Nd:YV04 to investigate its potential as a compact and simple single longitudinal mode …
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Lamination of a biodegradable polymeric microchip
… work builds on the initial design of a polymer microchip for controlled-release drug delivery. Currently, the microchip employs a nonbiodegradable sealant layer, and the new design aims to fabricate it only of biodegradable parts. Experiments were conducted to evaluate two potential designs that …
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Optofluidic microchip for biomedical and chemical sensing
… weapons in a sample of a person’s blood. These microchips could bring the capabilities of an entire medical laboratory to the places they are most desirable ‒ the developing world, the battlefield, and the home ‒ and where they could quickly detect Escherichia coli, anthrax, or the Human …
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Developing & applying a miniaturized active microchip device
Glioblastoma multiforme (GBM) is the most common and aggressive malignant brain tumor. Treatment of GBM is a daunting task with median survival just at 21 months. Methods of localized delivery have achieved moderate success in treating GBM. Depot devices have been limited due to the relatively …
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Microchip Liquid Chromatography and Capillary Electrophoresis Separations in Multilayer Microdevices
… was further evaluated for pressure driven microchip liquid chromatography (LC). Two micropumps were connected with reservoirs for sample and mobile phase, situated at the ends of microchannels for sample injection and separation, respectively. Columns micromachined in glass were coated …
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DEVELOPMENT OF MICROCHIP ELECTROPHORESIS BASED METHODS TO PROFILE CELLULAR NITROSATIVE STRESS
… as NO, ONOO-, glutathione and ascorbic acid. Microchip electrophoresis (ME) was selected as the separation method due to its fast analysis times, compatibility with low sample volumes and potential future application to chemical cytometry. Most prooxidants and antioxidants are …
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Utilizzo della tecnologia microchip per l'identificazione di geni candidati responsabili dell'aumento di HbF.
Expression of fetal globin is silenced normally in adult life; however, determinants linked and/or unlinked to the globin-gene clusters could modify Hb F expression so it persists into adults. Increased expression in adults offers hope as a cure for sickle cell disease (SCD) and b thalassemia, …
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Fluorescence of contaminants in soil and groundwater using a time-resolved microchip laser system
Thesis (Sc. D.)--Massachusetts Institute of Technology, Dept. of Civil and Environmental Engineering, 1998.
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Rapid separation of biologically important low molecular weight compounds by microchip electrophoresis and ultra-fast performance liquid chromatography
… important low molecular weight compounds by microchip electrophoresis and ultrahigh liquid chromatography. Chapter 1 introduces the theory and principles behind capillary electrophoresis separation. An overview of the history, different modes and detection techniques coupled to CE is …
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Membrane-Based Protein Preconcentration Microfluidic Devices
Interest in microchip capillary electrophoresis (CE) is growing due to the rapid analysis times provided and small sample input requirements. However, higher-concentration samples are typically needed because of the small (~pL) detection volumes in these devices. I have made membrane-based protein …
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Capillary and microchip gel electrophoresis using multiplexed fluorescence detection with both time-resolved and spectral-discrimination capabilities: applications in DNA sequencing using near-infrared fluorescence
… and time-resolved data during capillary and microchip electrophoresis. The utility of this hybrid fluorescence detector has been demonstrated by applying it to DNA sequencing applications. Coupling color discrimination with time-resolved fluorescence offers increased multiplexing capabilities …
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Detection of Proteins by Two-Photon Excitation of Native Fluorescence
… two-photon fluorescence detection on a microchip separation device. This detection is based on excitation of native fluorescence of aromatic amino acids by simultaneous absorption of two photons. First, a compact two-photon prototype detector was investigated. Its sensitivity was …
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Investigation of monolithic materials for protein sample preparation
… and porosity when fabricated inside a glass microchip. Evaluation of its performance was carried out by extraction of four standard proteins that were insulin, cytochrome C, myoglobin, and hemoglobin and the extraction recovery was in the range (79.1-98.4 %).A monolithic silica rod was …
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Development of a portable miniaturised capillary electrophoresis system for chemical nerve agents detection
… but sophisticated micro/nanofabricated silicon microchip device and with low-cost but disposal polymer microchip. This project output is an integrated chemistry workstation system for mobile on-site analysing tasks. All the thesis research belongs to the sub-work-package of the EU (European …
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Feasibility study of micro-laser induced breakdown spectroscopy applied to lead identification in metal alloys and environmental matrices
… study employed a passively Q-switched infrared Microchip laser, in conjunction with a time-integrated miniature charged-couple device array spectrometer. During the period of this research, the Microchip laser was available only through MIT Lincoln Laboratory. The unique features of the …
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Tunable Microchips for Imaging Protein Structures formed in Breast Cancer Cells
… methodology that employs silicon nitride (SiN) microchips to isolate BRCA1 assemblies from the nuclear material of breast cancer cells. These microchips are coated with adaptor proteins that include antibodies against target proteins of interest. The adaptor proteins are added in sequential …
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